公开(公告)号：US20190177401A1

公开(公告)日：2019-06-13

申请号：US16188489

申请日：2018-11-13

Applicant: H. Lundbeck A/S

Inventor： Jan Torleif Pedersen ,  Lars Østergaard Pedersen ,  Justus Claus Daechsel ,  Ayodeji Abdur-rasheed Asuni ,  Nina Helen Rosenqvist ,  Christiane Volbracht ,  Lone Helboe ,  Anders Brandt Elvang ,  Florence Sotty ,  Søren Christensen ,  Jeffrey B. Stavenhagen

IPC: C07K16/18 ,  A61K49/00 ,  G01N33/68 ,  A61K39/395

Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.