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公开(公告)号：US20190330320A1
公开(公告)日：2019-10-31
申请号：US16475299
申请日：2018-01-03
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist
Abstract: The present invention is based on antibodies which are both highly specific for hyperphosphorylated pathogenic P-S396 tau and highly specific for labelled sections of the human retina, as well as to methods of using these antibodies and their tau binding fragments in the treatment of retinoid amyloidosis, age related macular degeneration (ARMD), and glaucoma.
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公开(公告)号：US10995137B2
公开(公告)日：2021-05-04
申请号：US16475299
申请日：2018-01-03
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist
Abstract: The present invention is based on antibodies which are both highly specific for hyperphosphorylated pathogenic P-S396 tau and highly specific for labelled sections of the human retina, as well as to methods of using these antibodies and their tau binding fragments in the treatment of retinoid amyloidosis, age related macular degeneration (ARMD), and glaucoma.
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Patent Agency Ranking
公开(公告)号：US10647762B2
公开(公告)日：2020-05-12
申请号：US16371902
申请日：2019-04-01
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K49/00 , A61K39/395 , A61K39/00 , G01N33/68
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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公开(公告)号：US20190284266A1
公开(公告)日：2019-09-19
申请号：US16371902
申请日：2019-04-01
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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公开(公告)号：US10562962B2
公开(公告)日：2020-02-18
申请号：US16188489
申请日：2018-11-13
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , G01N33/68 , A61K49/00 , A61K39/00
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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公开(公告)号：US20190284265A1
公开(公告)日：2019-09-19
申请号：US16371867
申请日：2019-04-01
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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公开(公告)号：US20190177401A1
公开(公告)日：2019-06-13
申请号：US16188489
申请日：2018-11-13
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K49/00 , G01N33/68 , A61K39/395
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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