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公开(公告)号:US10934348B2
公开(公告)日:2021-03-02
申请号:US16723143
申请日:2019-12-20
Applicant: H. Lundbeck A/S
Inventor: Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , G01N33/68 , A61K49/00 , A61K39/00
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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公开(公告)号:US10196439B2
公开(公告)日:2019-02-05
申请号:US15207836
申请日:2016-07-12
Applicant: H. Lundbeck A/S
Inventor: Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68 , A61K39/00
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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公开(公告)号:US11739140B2
公开(公告)日:2023-08-29
申请号:US17144355
申请日:2021-01-08
Applicant: H. Lundbeck A/S
Inventor: Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , G01N33/68 , A61K49/00 , A61K39/00
CPC classification number: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/6896 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/4709 , G01N2800/2821
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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公开(公告)号:US10562962B2
公开(公告)日:2020-02-18
申请号:US16188489
申请日:2018-11-13
Applicant: H. Lundbeck A/S
Inventor: Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , G01N33/68 , A61K49/00 , A61K39/00
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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公开(公告)号:US20190177401A1
公开(公告)日:2019-06-13
申请号:US16188489
申请日:2018-11-13
Applicant: H. Lundbeck A/S
Inventor: Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K49/00 , G01N33/68 , A61K39/395
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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