公开(公告)号：US3682891A

公开(公告)日：1972-08-08

申请号：US3682891D

申请日：1970-01-09

Applicant: HOECHST AG

Inventor： RADSCHEIT KURT ,  FRITSCH WERNER ,  HAEDE WERNER ,  STACHE ULRICH ,  LINDNER ERNST

IPC: A61K20060101 ,  A61K36/00 ,  C07C20060101 ,  C07J19/00 ,  C07C173/00

CPC classification number: C07J19/005

Abstract: A METHOD FOR SYNTHESIZING ESTERS IN WHICH THE ACID MOIETY IS THAT OF A HYDROXY ACID AND THE ALCOHOL MOIETY IS A 3-HYDROXY-CARDENOLIDE OR 3-HYDOXY-BUFADIENOLIDE, BY ESTERIFYING THE STEROL WITH AN ACID ANHYDRIDE OR AN ACID CHLORIDE OF THE HYDROXY ACID, THE HYDROXY GROUPS OF WHICH HAVE BEEN ACETALIZED OR KETALIZED, AND THEN SELECTIVELY REMOVING SAID ACETAL OR KETAL GROUPS BY ACID HYDROLYSIS. CARDI-ACTIVE OXY-ESTERS PRODUCED BY THIS METHOD.

公开(公告)号：US3657228A

公开(公告)日：1972-04-18

申请号：US3657228D

申请日：1970-11-12

Applicant: HOECHST AG

Inventor： RADSCHEIT KURT ,  FRITSCH WERNER ,  HAEDE WERNER ,  STACHE ULRICH

IPC: D06M13/364 ,  C07C173/00

CPC classification number: D06M13/364

Abstract: MANUFACTURE OF 3B-HYDROXY-5B-CARDENOLIDES OF THE 14DEHYDRO OR 14B SERIES BY TREATMENT OF 3-DETO-5B-CARDENOLIDES WITH IRIDIUM (IV)-HYDROCHLORIC ACID, ITS SALTS OR IRIDIUM (III)-CHLORIDE IN THE PRESENCE OF TRIALKYL-PHOSPHITE.

公开(公告)号：US3483233A

公开(公告)日：1969-12-09

申请号：US3483233D

申请日：1967-03-14

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER ,  RADSCHEIT KURT ,  VOGEL GERHARD

IPC: A61K31/567 ,  A61K31/569 ,  A61K31/58 ,  C07J41/00 ,  C07J75/00 ,  C07C169/08 ,  C07C167/00

CPC classification number: A61K31/567 ,  A61K31/569 ,  A61K31/58 ,  C07J41/00 ,  C07J75/00

公开(公告)号：US3462421A

公开(公告)日：1969-08-19

申请号：US3462421D

申请日：1966-08-22

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER ,  VOGEL GERHARD

IPC: C07J1/00 ,  C07J5/00 ,  C07J17/00 ,  C07J21/00 ,  C07J75/00 ,  C07C169/12 ,  C07C169/24 ,  C07C169/36

CPC classification number: C07J21/00 ,  C07J1/00 ,  C07J5/00 ,  C07J17/00 ,  C07J75/00

公开(公告)号：US3461145A

公开(公告)日：1969-08-12

申请号：US3461145D

申请日：1967-02-28

Applicant: HOECHST AG

Inventor： HAEDE WERNER ,  RADSCHEIT KURT ,  FRITSCH WERNER ,  STACHE ULRICH ,  RUSCHIG HEINRICH

IPC: C07J5/00 ,  C07J75/00 ,  C07C169/36 ,  C07C167/28

CPC classification number: C07J5/00 ,  C07J75/00

公开(公告)号：US3455910A

公开(公告)日：1969-07-15

申请号：US3455910D

申请日：1967-02-17

Applicant: HOECHST AG

Inventor： FRITSCH WERNER ,  STACHE ULRICH ,  HAEDE WERNER ,  RADSCHEIT KURT

IPC: C07J19/00 ,  C07J75/00 ,  C07C167/00 ,  C07C173/00 ,  C07C173/02

CPC classification number: C07J19/00 ,  C07J75/00

公开(公告)号：US3420820A

公开(公告)日：1969-01-07

申请号：US3420820D

申请日：1966-08-31

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER

IPC: A61K31/585 ,  C07J19/00 ,  C07J75/00 ,  C07C173/00

CPC classification number: A61K31/585 ,  C07J19/00 ,  C07J75/00

公开(公告)号：US3879379A

公开(公告)日：1975-04-22

申请号：US12542571

申请日：1971-03-17

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER ,  RADSCHEIT KURT ,  LINDNER ERNST

IPC: A61K31/585 ,  C07D20060101 ,  C07J41/00 ,  C07C173/00

CPC classification number: C07J19/00

Abstract: Cardioactive 3-amino-cardenolides and a method for preparing them by reacting a 3-oxo-cardenolide with hydroxylamine or its salts to form a cardenolide-3-oxime and then catalytically hydrogenating this intermediate.

Abstract translation: 心脏活性3-氨基 - 己烯酸烯诺酯及其制备方法是通过使3-氧代 - 己烯酸烯醇与羟胺或其盐反应形成己内酰胺-3-肟，然后催化氢化该中间体。

公开(公告)号：US3642770A

公开(公告)日：1972-02-15

申请号：US3642770D

申请日：1969-03-25

Applicant: HOECHST AG

Inventor： HAEDE WERNER ,  STACHE ULRICH ,  FRITSCH WERNER ,  RADSCHEIT KURT

IPC: C07J19/00 ,  C07C173/00

CPC classification number: C07J19/00

Abstract: 2-R2,3,4-DI(R1-O-)-3,4-DIHYDRO-2H-PYRAN

AND METHODS OF MAKING THE SAME BY REACTING A STEROID ALCOHOL ROH, WITH A GLYCAL OF THE FORMULA

-CH2-O-R1 OR -CH(-O-R1)-CH2-O-R2

USEFUL FOR THE TREATMENT OF CARDIAC AND RENAL DISEASES, WHEREIN R IS A STEROID GROUP OF THE 3-HYDROXY-CARDENOLIDE OR 3-HYDROXYBUFADIENOLIDE SERIES, R1 IS ALIPHATIC OR AROMATIC ACYL, AND R2 IS HYDROGEN, METHYL, ETHYL, OR

2-(R-O-),5-(R''-O-),6-R2-5,6-DIHYDRO-2H-PYRAN

STEROID GLYCOSIDES OF THE FORMULA

公开(公告)号：US3639393A

公开(公告)日：1972-02-01

申请号：US3639393D

申请日：1969-04-15

Applicant: HOECHST AG

Inventor： FRITSCH WERNER ,  STACHE ULRICH ,  HAEDE WERNER ,  RADSCHEIT KURT

IPC: C07C173/02

CPC classification number: C07J19/00

Abstract: A PROCESS FOR PREPARING 3B,14B-DIHYDROXY-CARA-4,20(22)-DIENOLIDES WHICH COMPRISES REDUCING 3-OXO-CARDA4,14,20(22)-TRIENOLIDES BY MEANS OF COMLEX METAL HYDRIDES TO THE CORRESPONDING 3B-HYDROXY-CARDA-4,14,20(22)-TRIENOLIDES; TREATING THESE COMPOUNDS WITH ACYLATING AGENTS; REACTING THE RESULTING 3B-ACYLOXY-CARDA-4,14, 20(22)-TRIENOLDIES WITH N-BROMO-ACYL AMIDES, AND CATALYTICALLY HYDROGENATING THE 4B-ACYLOXY-3B,14B-DIHYDROXY5A,15A-DIBROMO-CARD-20(22)-ENOLIDES SO OBTAINED IN THE PRESENCE OF A PRECIOUS METAL CATALYST AT A PH IN THE RANGE FROM 4.5 TO 7.5. THE PRODUCTS OF THE INVENTION ARE VALUABLE THERAPEUTICS FOR ORAL ADMINISTRATION IN DISEASES OF THE HEART AND CIRCULATION.