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21.发明授权公开(公告)号：US07914787B2
公开(公告)日：2011-03-29
申请号：US12474665
申请日：2009-05-29
IPC分类号： A61K39/395 , A61K38/04 , C07K16/46 , C07K7/00
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译： 本发明涉及具有特异性结合目标组织的至少一个臂的特异性抗体或抗体片段以及特异性结合可靶向构建体的至少一个其他臂。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。
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22.发明申请公开(公告)号：US20090238757A1
公开(公告)日：2009-09-24
申请号：US12420864
申请日：2009-04-09
IPC分类号： A61K51/00 , A61K39/395 , A61K31/519 , A61K38/43 , A61K38/00 , A61K31/7088 , A61K33/22 , A61K49/00
CPC分类号： B82Y5/00 , A61K47/6891 , Y10S435/975
摘要： Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
摘要翻译： 描述了使用靶向抗体或其他靶向动物将治疗和诊断分子靶向特定类型的细胞的方法和组合物。
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23.发明授权公开(公告)号：US07405320B2
公开(公告)日：2008-07-29
申请号：US10776470
申请日：2004-02-11
IPC分类号： C07C229/00 , A61K39/00 , C07K1/00
CPC分类号： A61K51/0497 , A61K47/665 , A61K51/04 , A61K51/0455 , A61K51/048 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/06078 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
摘要： Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
摘要翻译： 公开了包含两个或多个通过间隔物或载体缀合的半抗原的化合物。 半抗原可以包括二亚乙基三胺五乙酸（DTPA），组氨酰胺 - 琥珀酰 - 谷氨酰胺（HSG）或DTPA和HSG的组合。 化合物还包括效应分子，其可以与一个或多个半抗原，间隔物/载体或两者结合。 效应分子可以通过多个键连接，包括酯键，亚氨基键，氨基键，硫键，硫代缩氨基脲键，缩氨基脲键，肟键，醚键或这些键的组合。 还公开了合成化合物的化合物和/或前体的方法。
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24.发明申请Production and Use of Novel Peptide-Based Agents with Bispecific Antibodies 有权新型基于肽的药物与双特异性抗体的生产和应用公开(公告)号：US20100008855A1
公开(公告)日：2010-01-14
申请号：US12474665
申请日：2009-05-29
IPC分类号： A61K49/00 , A61K39/395 , A61K51/08 , A61K49/22 , A61K38/18 , A61K33/22 , A61K38/43 , A61K38/20 , A61K38/21 , A61K31/704 , A61K31/7048 , A61K31/519
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译： 本发明涉及具有特异性结合目标组织的至少一个臂的特异性抗体或抗体片段以及特异性结合可靶向构建体的至少一个其他臂。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。
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25.发明授权公开(公告)号：US07560110B2
公开(公告)日：2009-07-14
申请号：US11198846
申请日：2005-08-08
IPC分类号： A61K39/395
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译： 本发明涉及具有特异性结合目标组织的至少一个臂的特异性抗体或抗体片段以及特异性结合可靶向构建体的至少一个其他臂。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。
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26.发明授权公开(公告)号：US08158573B2
公开(公告)日：2012-04-17
申请号：US12138065
申请日：2008-06-12
IPC分类号： A01N61/00
CPC分类号： A61K51/0497 , A61K47/665 , A61K51/04 , A61K51/0455 , A61K51/048 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/06078 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
摘要： Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
摘要翻译： 公开了包含两个或多个通过间隔物或载体缀合的半抗原的化合物。 半抗原可以包括二亚乙基三胺五乙酸（DTPA），组氨酰胺 - 琥珀酰 - 谷氨酰胺（HSG）或DTPA和HSG的组合。 化合物还包括效应分子，其可以与一个或多个半抗原，间隔物/载体或两者结合。 效应分子可以通过多个键连接，包括酯键，亚氨基键，氨基键，硫键，硫代缩氨基脲键，缩氨基脲键，肟键，醚键或这些键的组合。 还公开了合成化合物的化合物和/或前体的方法。
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27.发明授权公开(公告)号：US07892547B2
公开(公告)日：2011-02-22
申请号：US12420864
申请日：2009-04-09
IPC分类号： A61K39/00 , A61K39/44 , A61K38/08 , A61K39/395 , A61K49/06 , C12P21/08 , C07K16/18 , C07K16/22 , C07K16/24
CPC分类号： B82Y5/00 , A61K47/6891 , Y10S435/975
摘要： Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
摘要翻译： 描述了使用靶向抗体或其他靶向动物将治疗和诊断分子靶向特定类型的细胞的方法和组合物。
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28.发明授权公开(公告)号：US07534431B2
公开(公告)日：2009-05-19
申请号：US10768707
申请日：2004-02-02
IPC分类号： A61K39/00 , A61K39/44 , A61K38/08 , A61K39/395 , A61K49/06 , A61K49/16 , C12P21/08 , C07K16/18 , C07K16/22 , C07K16/24
CPC分类号： B82Y5/00 , A61K47/6891 , Y10S435/975
摘要： Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
摘要翻译： 描述了使用靶向抗体或其他靶向动物将治疗和诊断分子靶向特定类型的细胞的方法和组合物。
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29.发明授权Methods and compositions for improved 18F labeling of proteins, peptides and other molecules 有权用于改进蛋白质，肽和其他分子的18F标记的方法和组合物公开(公告)号：US08545809B2
公开(公告)日：2013-10-01
申请号：US13323139
申请日：2011-12-12
CPC分类号： A61K51/08 , A61B5/055 , A61K47/48746 , A61K47/6897 , A61K49/06 , A61K51/0406 , A61K51/041 , A61K51/044 , A61K51/0482 , A61K51/0491 , A61K51/082 , A61K51/083 , A61K51/088 , A61K51/109 , B82Y5/00 , C07D225/00 , C07F13/005
摘要： The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.
摘要翻译： 本申请公开了在PET，SPECT和/或MR成像中合成和使用18F或19F标记的分子的组合物和方法。 优选地，18F或19F通过与IIIA族金属形成络合物并将该复合物与双功能螯合剂结合（其可以直接或间接连接到靶向分子）而与靶向分子缀合。 在其它实施方案中，18F或19F标记的部分可以包含与靶向疾病相关抗原的双特异性抗体组合使用的可靶向构建体。 所公开的方法和组合物允许在30分钟或更短时间内非常高的效率和比活性的分子的简单且可重现的标记。 在优选的实施方案中，标记的分子可以在标记后不经纯化用于受试者的成像。
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30.发明授权公开(公告)号：US08444956B2
公开(公告)日：2013-05-21
申请号：US13474260
申请日：2012-05-17
CPC分类号： C07K19/00 , A61K47/6897 , A61K51/0406 , A61K51/0491 , A61K51/08 , A61K51/082 , A61K51/083 , A61K51/088 , A61K51/109 , B82Y5/00
摘要： The present application discloses compositions and methods of synthesis and use of 68Ga, 18F or 19F labeled molecules of use in PET or MRI imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a chelating moiety, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 68Ga, 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. In more preferred embodiments, a chelating moiety or targetable construct may be conjugated to a targeting molecule, such as an antibody or antibody fragment.
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