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1.发明授权公开(公告)号：US07534431B2
公开(公告)日：2009-05-19
申请号：US10768707
申请日：2004-02-02
IPC分类号： A61K39/00 , A61K39/44 , A61K38/08 , A61K39/395 , A61K49/06 , A61K49/16 , C12P21/08 , C07K16/18 , C07K16/22 , C07K16/24
CPC分类号： B82Y5/00 , A61K47/6891 , Y10S435/975
摘要： Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
摘要翻译： 描述了使用靶向抗体或其他靶向动物将治疗和诊断分子靶向特定类型的细胞的方法和组合物。
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2.发明申请公开(公告)号：US20110117010A1
公开(公告)日：2011-05-19
申请号：US12985775
申请日：2011-01-06
CPC分类号： B82Y5/00 , A61K47/6891 , Y10S435/975
摘要： Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
摘要翻译： 描述了使用靶向抗体或其他靶向动物将治疗和诊断分子靶向特定类型的细胞的方法和组合物。
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公开(公告)号：US07138103B2
公开(公告)日：2006-11-21
申请号：US10150654
申请日：2002-05-17
IPC分类号： A61K38/04 , A61K39/395 , A61K49/04 , A61K49/06 , A61K51/00
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the targetable constructs and bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译： 本发明涉及可由具有特异性结合构建体的至少一个臂的双特异性抗体或抗体片段结合的可靶向构建体。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生可靶向构建体和双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。
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4.发明授权公开(公告)号：US08097252B2
公开(公告)日：2012-01-17
申请号：US12985775
申请日：2011-01-06
IPC分类号： A61K39/00 , A61K39/44 , A61K38/08 , A61K39/395 , A61K49/06 , C12P21/08 , C07K16/18 , C07K16/22 , C07K16/24
CPC分类号： B82Y5/00 , A61K47/6891 , Y10S435/975
摘要： Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
摘要翻译： 描述了使用靶向抗体或其他靶向动物将治疗和诊断分子靶向特定类型的细胞的方法和组合物。
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5.发明申请公开(公告)号：US20120063993A1
公开(公告)日：2012-03-15
申请号：US12138065
申请日：2008-06-12
IPC分类号： A61K51/00 , C07K7/02 , C12N9/00 , A61K9/127 , A61K38/20 , A61K38/21 , A61K38/19 , A61K49/00 , A61P9/00 , A61P31/00 , A61P37/02 , A61P35/00 , A61P3/00 , A61P25/00 , A61P31/04 , A61P31/10 , A61P33/00 , A61P33/02 , A61P35/02 , A61K39/395 , B82Y5/00
CPC分类号： A61K51/0497 , A61K47/665 , A61K51/04 , A61K51/0455 , A61K51/048 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/06078 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
摘要： Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
摘要翻译： 公开了包含两个或多个通过间隔物或载体缀合的半抗原的化合物。 半抗原可以包括二亚乙基三胺五乙酸（DTPA），组氨酰胺 - 琥珀酰 - 谷氨酰胺（HSG）或DTPA和HSG的组合。 化合物还包括效应分子，其可以与一个或多个半抗原，间隔物/载体或两者结合。 效应分子可以通过多个键连接，包括酯键，亚氨基键，氨基键，硫键，硫代缩氨基脲键，缩氨基脲键，肟键，醚键或这些键的组合。 还公开了合成化合物的化合物和/或前体的方法。
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6.发明授权公开(公告)号：US07914787B2
公开(公告)日：2011-03-29
申请号：US12474665
申请日：2009-05-29
IPC分类号： A61K39/395 , A61K38/04 , C07K16/46 , C07K7/00
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译： 本发明涉及具有特异性结合目标组织的至少一个臂的特异性抗体或抗体片段以及特异性结合可靶向构建体的至少一个其他臂。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。
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7.发明申请公开(公告)号：US20090238757A1
公开(公告)日：2009-09-24
申请号：US12420864
申请日：2009-04-09
IPC分类号： A61K51/00 , A61K39/395 , A61K31/519 , A61K38/43 , A61K38/00 , A61K31/7088 , A61K33/22 , A61K49/00
CPC分类号： B82Y5/00 , A61K47/6891 , Y10S435/975
摘要： Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
摘要翻译： 描述了使用靶向抗体或其他靶向动物将治疗和诊断分子靶向特定类型的细胞的方法和组合物。
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8.发明授权公开(公告)号：US07405320B2
公开(公告)日：2008-07-29
申请号：US10776470
申请日：2004-02-11
IPC分类号： C07C229/00 , A61K39/00 , C07K1/00
CPC分类号： A61K51/0497 , A61K47/665 , A61K51/04 , A61K51/0455 , A61K51/048 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/06078 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
摘要： Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
摘要翻译： 公开了包含两个或多个通过间隔物或载体缀合的半抗原的化合物。 半抗原可以包括二亚乙基三胺五乙酸（DTPA），组氨酰胺 - 琥珀酰 - 谷氨酰胺（HSG）或DTPA和HSG的组合。 化合物还包括效应分子，其可以与一个或多个半抗原，间隔物/载体或两者结合。 效应分子可以通过多个键连接，包括酯键，亚氨基键，氨基键，硫键，硫代缩氨基脲键，缩氨基脲键，肟键，醚键或这些键的组合。 还公开了合成化合物的化合物和/或前体的方法。
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9.发明申请Production and Use of Novel Peptide-Based Agents with Bispecific Antibodies 有权新型基于肽的药物与双特异性抗体的生产和应用公开(公告)号：US20100008855A1
公开(公告)日：2010-01-14
申请号：US12474665
申请日：2009-05-29
IPC分类号： A61K49/00 , A61K39/395 , A61K51/08 , A61K49/22 , A61K38/18 , A61K33/22 , A61K38/43 , A61K38/20 , A61K38/21 , A61K31/704 , A61K31/7048 , A61K31/519
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译： 本发明涉及具有特异性结合目标组织的至少一个臂的特异性抗体或抗体片段以及特异性结合可靶向构建体的至少一个其他臂。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。
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10.发明授权公开(公告)号：US07560110B2
公开(公告)日：2009-07-14
申请号：US11198846
申请日：2005-08-08
IPC分类号： A61K39/395
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译： 本发明涉及具有特异性结合目标组织的至少一个臂的特异性抗体或抗体片段以及特异性结合可靶向构建体的至少一个其他臂。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。
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