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    CRYSTALLINE BASE OF CITALOPRAM
    22.
    发明申请
    CRYSTALLINE BASE OF CITALOPRAM 审中-公开
    CITALOPRAM的晶体碱基

    公开(公告)号：US20060229459A1

    公开(公告)日：2006-10-12

    申请号：US11425308

    申请日：2006-06-20

    申请人： Hans Petersen ,  Klaus Bogeso ,  Per Holm

    发明人： Hans Petersen ,  Klaus Bogeso ,  Per Holm

    IPC分类号： C07D307/02

    CPC分类号： C07D307/81 ,  H01M8/04156 ,  H01M8/04171 ,  H01M8/04186 ,  H01M8/1009 ,  H01M8/1011 ,  H01M8/241 ,  H01M8/2455 ,  H01M8/246 ,  Y02E60/523

    摘要： The present invention relates to the crystalline base of the well known antidepressant drug citalopram, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of citalopram, such as the hydrobromide, using the base, the salts obtained by said process and formulations containing such salts.

    摘要翻译： 本发明涉及众所周知的抗抑郁药物西酞普兰，1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃腈的结晶碱，所述碱的制剂， 制备西酞普兰纯化盐的方法，例如使用碱的氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂。

    Method for the preparation of citalopram
    25.
    发明授权
    Method for the preparation of citalopram 失效
    西酞普兰制备方法

    公开(公告)号：US06762308B2

    公开(公告)日：2004-07-13

    申请号：US10237145

    申请日：2002-09-05

    申请人： Hans Petersen

    发明人： Hans Petersen

    IPC分类号： C07D30787

    CPC分类号： C07D307/87

    摘要： The present invention relates to a method for the preparation of citalopram by alkylation of a 1-(4-fluorophenyl)-1,3-dihydroisobenzofurane derivative.

    摘要翻译： 本发明涉及通过1-（4-氟苯基）-1,3-二氢异苯并呋喃衍生物的烷基化制备西酞普兰的方法。

    Method for the preparation of citalopram
    26.
    发明授权
    Method for the preparation of citalopram 失效
    西酞普兰制备方法

    公开(公告)号：US06717000B2

    公开(公告)日：2004-04-06

    申请号：US10238843

    申请日：2002-09-09

    申请人： Hans Petersen

    发明人： Hans Petersen

    IPC分类号： C07D30778

    CPC分类号： C07D307/87

    摘要： The present invention relates to a method for the preparation of citalopram comprising reduction of a compound of formula wherein X is a cyano group or a group which can be converted to a cyano group, and if X is not a cyano group followed by conversion of X to a cyano group.

    摘要翻译： 本发明涉及一种制备西酞普兰的方法，包括还原糠醛的化合物X是氰基或可以转化成氰基的基团，如果X不是氰基，随后将X转化为 氰基。

    Method for the preparation of citalopram
    27.
    发明授权
    Method for the preparation of citalopram 有权
    西酞普兰制备方法

    公开(公告)号：US06229026B1

    公开(公告)日：2001-05-08

    申请号：US09479832

    申请日：2000-01-07

    申请人： Hans Petersen

    发明人： Hans Petersen

    IPC分类号： C07D30783

    CPC分类号： C07D307/87 ,  C07C229/38 ,  C07C235/84 ,  C07C237/30

    摘要： A method for the preparation of citalopram comprising the steps of reacting a compound of Formula (IV) wherein R1 is C1-6 alkyl and X is O or NH, successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent of 3-halogen-N,N-dimethylpropylamine, respectively, effecting ring-closure of the resulting compound of Formula (V) wherein R1 and X are as defined above, and converting the resulting 1,3-dihydroisobenzofuran compound to the corresponding 5-cyano derivative, i.e. citalopram.

    摘要翻译： 一种制备西酞普兰的方法，包括以下步骤：使R 1为C 1-6烷基且X为O或NH的式（Ⅳ）化合物依次与4-卤代 - 氟苯基的格氏试剂和3位的格利雅试剂 - 卤素-N，N-二甲基丙胺，使所得到的式（Ⅴ）化合物闭环，其中R 1和X如上定义，并将所得1,3-二氢异苯并呋喃化合物转化为相应的5-氰基衍生物 ，即西酞普兰。

    Solenoid Actuated Valve with a Damping Device
    28.
    发明申请
    Solenoid Actuated Valve with a Damping Device 失效
    带阻尼装置的电磁阀

    公开(公告)号：US20080067461A1

    公开(公告)日：2008-03-20

    申请号：US11662164

    申请日：2005-09-09

    申请人： Hans Petersen

    发明人： Hans Petersen

    IPC分类号： F16K31/06

    CPC分类号： F16K31/0689 ,  F16K31/0693 ,  F16K51/02

    摘要： The invention provides a solenoid actuated valve with a plunger which moves in a sleeve under influence of a magnetic field from the solenoid and further comprising a damping device for reducing noise and wear caused by the plunger when it bounces against a top part located in the sleeve. The damping device comprises a first part which forms the limit of the travel of the plunger and another part which is allowed to move relative to the first part in a dampened movement. To enable application in a vacuum system, the damping device comprises a conduit which allows evacuation of a chamber confined between one end of the sleeve and the damping device. The invention further provides a damper for a solenoid actuated valve.

    摘要翻译： 本发明提供了一种电磁致动阀，其具有柱塞，其在来自螺线管的磁场的影响下在套筒中移动，并且还包括阻尼装置，用于在柱塞反弹抵靠位于套筒中的顶部部分时引起的噪声和磨损 。 阻尼装置包括形成柱塞的行进极限的第一部分和允许相对于第一部分在阻尼运动中移动的另一部分。 为了能够在真空系统中应用，阻尼装置包括导管，其能够排出限定在套筒的一端和阻尼装置之间的腔室。 本发明还提供一种用于电磁致动阀的阻尼器。

    Spring and a Valve Incorporating Such a Spring
    29.
    发明申请
    Spring and a Valve Incorporating Such a Spring 审中-公开
    春天和一个并入这样的春天的阀门

    公开(公告)号：US20080017255A1

    公开(公告)日：2008-01-24

    申请号：US11662158

    申请日：2005-09-09

    申请人： Hans Petersen

    发明人： Hans Petersen

    IPC分类号： F16K17/00 ,  F16F1/04

    CPC分类号： F16F1/04 ,  F16F1/123 ,  F16K31/408 ,  Y10T137/7876

    摘要： The invention provides an assembly spring and a valve incorporating such a spring. The spring is made from a wire which extends around a longitudinal axis to form windings. The spring terminates in axially opposite end portions in first and second end windings. The end windings each has an arcuate portion wherein the wire extends around the longitudinal axis. The end windings serve to fasten the spring in a groove of an element to which the spring is being attached. The end winding further has a free end portion wherein a free wire end extends outwardly away from the longitudinal axis to form gripping means. The spring thereby facilitates easy attaching of the end winding to the element. In particular, the spring is applicable for attaching a valve element to a plunger in a valve, e.g. a servo valve.

    摘要翻译： 本发明提供一种组装弹簧和结合这种弹簧的阀。 弹簧由围绕纵向轴线延伸以形成绕组的导线制成。 弹簧终止在第一和第二端绕组的轴向相对端部。 端部绕组各自具有弓形部分，其中线围绕纵向轴线延伸。 端部绕组用于将弹簧紧固在与其连接的弹簧的元件的槽中。 端部绕组还具有自由端部，其中自由线端部从纵向轴线向外延伸以形成夹紧装置。 因此弹簧便于端部绕组容易地附接到元件。 特别地，弹簧适用于将阀元件附接到阀中的柱塞，例如， 伺服阀。

    Servo valve for a vacuum system
    30.
    发明申请
    Servo valve for a vacuum system 失效
    用于真空系统的伺服阀

    公开(公告)号：US20070040134A1

    公开(公告)日：2007-02-22

    申请号：US10556203

    申请日：2004-05-24

    申请人： Hans Petersen

    发明人： Hans Petersen

    IPC分类号： F16K31/124

    CPC分类号： F16K51/02 ,  F16K31/408

    摘要： The invention provides a servo valve which is operable in vacuum systems and can be switched between an open and a closed state even by use of low forces. For that purpose, the valve has a closure member (4) moving between the open and a closed position under influence of a difference between a control pressure of a control chamber (13) and the pressures of the intake (2) and outlet (3), respectively. The control chamber is in constant fluid communication with the intake, and in adjustable fluid communication with the outlet to influence the control pressure mainly by the intake pressure and the outlet pressure depending on the adjustable fluid communication. The invention further provides a vacuum system with such a servo valve.

    摘要翻译： 本发明提供了一种伺服阀，其可在真空系统中操作，并且即使通过使用较低的力也可在打开和关闭状态之间切换。 为此目的，阀具有在控制室（13）的控制压力和进气口（2）和出口（3）的压力之间的差异的影响下在打开和关闭位置之间移动的关闭构件（4） ）， 分别。 控制室与进气口恒定流体连通，并且与出口可调节流体连通以主要根据可调节流体连通的进气压力和出口压力来影响控制压力。 本发明还提供一种具有这种伺服阀的真空系统。