公开(公告)号：US12240911B2

公开(公告)日：2025-03-04

申请号：US16684258

申请日：2019-11-14

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Ralf Hosse ,  Christian Klein ,  Viktor Levitski ,  Pablo Umana

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  A61K39/00

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) at least one moiety capable of specific binding to a costimulatory TNF receptor family member, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US11821897B2

公开(公告)日：2023-11-21

申请号：US16448571

申请日：2019-06-21

Applicant: Hoffmann-La Roche Inc.

Inventor： Regula Buser ,  Sandra Grau-Richards ,  Virginie Steinhart

IPC: G01N33/542 ,  C12N15/85 ,  G01N21/64 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  G01N33/53 ,  G01N33/536 ,  G01N33/533

CPC classification number: G01N33/542 ,  C12N15/85 ,  G01N21/6408 ,  G01N21/6428 ,  G01N33/53 ,  G01N33/533 ,  G01N33/536 ,  G01N33/54306 ,  G01N33/56966 ,  G01N33/56972 ,  G01N33/586 ,  G01N2021/6439

Abstract: The present invention relates to a new cell based assay for determining antibody or ligand binding and function using lipid-like compounds capable of spontaneous integration into cell membranes.

公开(公告)号：US11453722B2

公开(公告)日：2022-09-27

申请号：US16584931

申请日：2019-09-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Sandra Grau-Richards ,  Christian Klein ,  Mudita Pincha ,  Pablo Umaña

IPC: C07K16/28 ,  C07K16/18

Abstract: The invention relates to novel bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to tenascin C (TnC), and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20220267395A1

公开(公告)日：2022-08-25

申请号：US17455617

申请日：2021-11-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K14/525 ,  C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  C07K16/30 ,  A61K39/395

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US11267903B2

公开(公告)日：2022-03-08

申请号：US16522412

申请日：2019-07-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  A61K38/00 ,  C07K16/40 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US20200150039A1

公开(公告)日：2020-05-14

申请号：US16448571

申请日：2019-06-21

Applicant: Hoffmann-La Roche Inc.

Inventor： Regula Buser ,  Sandra Grau-Richards ,  Virginie Steinhart

IPC: G01N21/64 ,  C12N15/85 ,  G01N33/543

Abstract: The present invention relates to a new cell based assay for determining antibody or ligand binding and function using lipid-like compounds capable of spontaneous integration into cell membranes

公开(公告)号：US20190382507A1

公开(公告)日：2019-12-19

申请号：US16522412

申请日：2019-07-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US09975958B2

公开(公告)日：2018-05-22

申请号：US14934639

申请日：2015-11-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Peter Bruenker ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K16/28 ,  C07K16/40 ,  C07K14/78

CPC classification number: C07K16/2878 ,  C07K14/78 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/66 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/35 ,  C07K2319/70 ,  C07K2319/74

Abstract: The present invention pertains to a trimeric antigen binding molecule comprising three fusion polypeptides, each comprising at least one antigen binding moiety fused to a trimerization domain derived from human cartilage matrix protein. In addition, the present invention relates to polynucleotides encoding such trimeric antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the trimeric antigen binding molecules of the invention, and to methods of using these trimeric antigen binding molecules in the treatment of disease.

公开(公告)号：US20160340399A1

公开(公告)日：2016-11-24

申请号：US15087405

申请日：2016-03-31

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K14/525

CPC classification number: C07K14/525 ,  A61K38/00 ,  A61K39/395 ,  C07K14/705 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/3007 ,  C07K16/3053 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2319/035 ,  C07K2319/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

Abstract translation: 本发明涉及包含（a）能够与靶细胞抗原特异性结合的至少一个部分的（b）包含TNF配体家族成员或其片段的三个胞外域的多肽的新型含有TNF家族配体三聚体的抗原结合分子， 通过肽接头彼此连接，和（c）由能够稳定结合的第一和第二亚单位组成的Fc结构域，以及产生这些分子的方法及其使用方法。