公开(公告)号：US06821546B1

公开(公告)日：2004-11-23

申请号：US09568578

申请日：2000-05-11

申请人： Ikuo Kimura ,  Genji Ito ,  Masayuki Nasu

发明人： Ikuo Kimura ,  Genji Ito ,  Masayuki Nasu

IPC分类号： A23L1325

CPC分类号： A23B4/20 ,  A23L17/00 ,  A23L17/70

摘要： This invention provides a process for production of surimi with stable quality from fish infected with the parasite Ichthyophonus hoferi, and a process for production of surimi based products of good quality using the surimi as the raw material. In the process for production of surimi from parasite-infected fish, an additive for inhibiting protease activity and recovering gel-forming capability, and calcium are added in the process of production of surimi from fish infected with Ichthyophonus hoferi, preferably from Alaska pollock. A protease inhibitor, preferably a thiol protease inhibitor, is used as the additive.

摘要翻译： 本发明提供了一种生产具有来自感染寄生虫鱼腥草鱼的质量稳定的鱼糜的方法，以及以鱼糜为原料生产质量好的鱼糜产品的方法。 在从寄生虫感染的鱼生产鱼糜的过程中，在鱼腥草感染的鱼类，优选来自阿拉斯加鳕鱼的鱼糜的生产过程中加入了用于抑制蛋白酶活性和回收凝胶形成能力的添加剂和钙。 使用蛋白酶抑制剂，优选硫醇蛋白酶抑制剂作为添加剂。

公开(公告)号：US5583227A

公开(公告)日：1996-12-10

申请号：US458871

申请日：1995-06-02

申请人： Takeshi Niho ,  Ichiro Yamamoto ,  Hidenori Mochizuki ,  Ikuo Kimura ,  Akihiro Imai ,  Tetsuyuki Nakase

发明人： Takeshi Niho ,  Ichiro Yamamoto ,  Hidenori Mochizuki ,  Ikuo Kimura ,  Akihiro Imai ,  Tetsuyuki Nakase

IPC分类号： C07D241/24 ,  C07D241/42 ,  C07D241/44 ,  A61K31/33

CPC分类号： C07D241/24 ,  C07D241/42 ,  C07D241/44

摘要： This invention relates to a novel compound which is useful as a drug in preventing and/or treating peptic ulcer-related diseases, to a production process thereof and to a pharmaceutical composition containing the same.Particularly, it provides a compound which has a specified substituted alkynylpyrazine nucleus or a specified substituted alkynylquinoxaline nucleus, represented by the following formula (I) ##STR1## wherein A is represented by the following formula (II) or (III) ##STR2## and R.sup.1 is represented by the following formula (IV), ##STR3## and the salts thereof, a production process thereof and a pharmaceutical composition containing the same.The inventive compound is useful as a drug in preventing and/or treating peptic ulcer-related diseases.

摘要翻译： 本发明涉及可用作预防和/或治疗消化性溃疡相关疾病的药物的新型化合物及其制备方法和含有该化合物的药物组合物。 特别地，其提供具有指定的取代的炔基吡嗪核的化合物或由下式（I）表示的特定的取代的炔基喹喔啉核，其中A由下式（II）或（III）表示： （II）＆lt; IMAGE＆gt;（III），R1由下式（Ⅳ），ⅩⅧ及其盐表示，其制备方法和含有该化合物的药物组合物。 本发明化合物可用作预防和/或治疗消化性溃疡相关疾病的药物。