公开(公告)号：US20220213107A1

公开(公告)日：2022-07-07

申请号：US17537674

申请日：2021-11-30

申请人： Incyte Corporation

发明人： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P25/28

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11078204B2

公开(公告)日：2021-08-03

申请号：US16681014

申请日：2019-11-12

申请人： Incyte Corporation

发明人： Stacey Shepard ,  Yanran Ai ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Artem Shvartsbart

IPC分类号： A61K31/4985 ,  A61K31/53 ,  A61P9/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C07D487/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US10975088B2

公开(公告)日：2021-04-13

申请号：US16591017

申请日：2019-10-02

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Stacey Shepard ,  Eddy W. Yue ,  Artem Shvartsbart ,  David M. Burns ,  Daniel Levy

IPC分类号： A61K31/53 ,  C07D487/04 ,  C07D471/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20200339542A1

公开(公告)日：2020-10-29

申请号：US16847975

申请日：2020-04-14

申请人： Incyte Corporation

发明人： Stacey Shepard ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Lixin Shao

IPC分类号： C07D403/04 ,  C07D403/14 ,  C07D403/08 ,  C07D413/04 ,  C07D417/04 ,  C07D405/12 ,  C07D241/20 ,  C07B59/00 ,  A61P35/00 ,  A61P9/00 ,  A61P25/28 ,  A61P37/02 ,  C07D241/28

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US10669262B2

公开(公告)日：2020-06-02

申请号：US16295705

申请日：2019-03-07

申请人： Incyte Corporation

发明人： Stacey Shepard ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Lixin Shao

IPC分类号： C07D213/40 ,  C07D241/20 ,  C07D403/04 ,  C07D403/14 ,  C07D403/08 ,  C07D413/04 ,  C07D417/04 ,  C07D405/12 ,  C07B59/00 ,  A61P35/00 ,  A61P9/00 ,  A61P25/28 ,  A61P37/02 ,  C07D241/28

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US10472358B2

公开(公告)日：2019-11-12

申请号：US15927170

申请日：2018-03-21

申请人： Incyte Corporation

发明人： Andrew P. Combs ,  Thomas P. Maduskuie, Jr. ,  Nikoo Falahatpisheh

IPC分类号： C07D471/04 ,  A61K31/546

摘要： The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

公开(公告)号：US20190119287A1

公开(公告)日：2019-04-25

申请号：US16165390

申请日：2018-10-19

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Stacey Shepard ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  C07D519/00 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07B2200/13 ,  C07D471/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20190062336A1

公开(公告)日：2019-02-28

申请号：US16045358

申请日：2018-07-25

申请人： Incyte Corporation

发明人： Artem Shvartsbart ,  Stacey Shepard ,  Andrew P. Combs ,  Lixin Shao ,  Nikoo Falahatpisheh ,  Ge Zou ,  Andrew W. Buesking ,  Richard B. Sparks ,  Eddy W. Yue ,  Ravi Kumar Jalluri

IPC分类号： C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61P17/06 ,  A61P19/02 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US12030885B2

公开(公告)日：2024-07-09

申请号：US17183253

申请日：2021-02-23

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Stacey Shepard ,  Eddy W. Yue ,  Artem Shvartsbart ,  David M. Burns ,  Daniel Levy

IPC分类号： A61K31/53 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00 ,  C07B2200/13

摘要： This application relates to compounds of Formula (I):






or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11773102B2

公开(公告)日：2023-10-03

申请号：US17356984

申请日：2021-06-24

申请人： Incyte Corporation

发明人： Artem Shvartsbart ,  Stacey Shepard ,  Andrew P. Combs ,  Lixin Shao ,  Nikoo Falahatpisheh ,  Ge Zou ,  Andrew W. Buesking ,  Richard B. Sparks ,  Eddy W. Yue ,  Ravi Kumar Jalluri

IPC分类号： A61P35/00 ,  A61K31/519 ,  A61P17/06 ,  A61P35/02 ,  A61P37/06 ,  A61P35/04 ,  A61P19/02 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61P17/06 ,  A61P19/02 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/06 ,  C07D519/00

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.