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公开(公告)号:US11952367B2
公开(公告)日:2024-04-09
申请号:US17705079
申请日:2022-03-25
申请人: Incyte Corporation
发明人: Richard B. Sparks , Stacey Shepard , Andrew P. Combs , Andrew W. Buesking , Lixin Shao , Haisheng Wang , Nikoo Falahatpisheh
IPC分类号: C07D401/14 , C07D403/14 , C07D405/14 , C07D487/08 , C07D487/10 , C07D491/107
CPC分类号: C07D401/14 , C07D403/14 , C07D405/14 , C07D487/08 , C07D487/10 , C07D491/107
摘要: The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
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公开(公告)号:US11926630B2
公开(公告)日:2024-03-12
申请号:US17537674
申请日:2021-11-30
申请人: Incyte Corporation
发明人: Brent Douty , Andrew W. Buesking , David M. Burns , Andrew P. Combs , Nikoo Falahatpisheh , Ravi Kumar Jalluri , Daniel Levy , Padmaja Polam , Lixin Shao , Stacey Shepard , Artem Shvartsbart , Richard B. Sparks , Eddy W. Yue
IPC分类号: C07D487/04 , A61P35/00 , A61P25/28
CPC分类号: C07D487/04 , A61P25/28 , A61P35/00 , C07B2200/07 , C07B2200/13
摘要: This application relates to compounds of Formula (I):
or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.-
公开(公告)号:US11702416B2
公开(公告)日:2023-07-18
申请号:US17339546
申请日:2021-06-04
申请人: Incyte Corporation
IPC分类号: C07D471/04 , A61K31/546
CPC分类号: C07D471/04 , A61K31/546
摘要: The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
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公开(公告)号:US11046658B2
公开(公告)日:2021-06-29
申请号:US16458530
申请日:2019-07-01
申请人: Incyte Corporation
发明人: Brent Douty , Yanran Ai , David M. Burns , Andrew P. Combs , Nikoo Falahatpisheh , Daniel Levy , Padmaja Polam , Lixin Shao , Stacey Shepard , Artem Shvartsbart , Eddy W. Yue , Andrew W. Buesking
IPC分类号: C07D241/20 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/04 , C07D417/04 , C07D471/04 , C07D471/06 , C07D487/04
摘要: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
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5.
公开(公告)号:US20200048251A1
公开(公告)日:2020-02-13
申请号:US16658445
申请日:2019-10-21
申请人: Incyte Corporation
IPC分类号: C07D471/04 , A61K31/546
摘要: The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
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公开(公告)号:US10065963B2
公开(公告)日:2018-09-04
申请号:US15343375
申请日:2016-11-04
申请人: Incyte Corporation
发明人: Artem Shvartsbart , Stacey Shepard , Andrew P. Combs , Lixin Shao , Nikoo Falahatpisheh , Ge Zou , Eddy W. Yue , Ravi Kumar Jalluri
IPC分类号: C07D487/04 , A61K31/519 , C07D519/00 , A61P35/00 , A61P9/00 , A61P25/28 , A61P29/00
摘要: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
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公开(公告)号:US09957268B2
公开(公告)日:2018-05-01
申请号:US15354223
申请日:2016-11-17
申请人: Incyte Corporation
IPC分类号: C07D471/04 , A61K31/546
CPC分类号: C07D471/04 , A61K31/546
摘要: The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
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公开(公告)号:US20170158689A1
公开(公告)日:2017-06-08
申请号:US15354223
申请日:2016-11-17
申请人: Incyte Corporation
IPC分类号: C07D471/04 , A61K31/546
CPC分类号: C07D471/04 , A61K31/546
摘要: The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.
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公开(公告)号:US20170129899A1
公开(公告)日:2017-05-11
申请号:US15343375
申请日:2016-11-04
申请人: Incyte Corporation
发明人: Artem Shvartsbart , Stacey Shepard , Andrew P. Combs , Lixin Shao , Nikoo Falahatpisheh , Ge Zou , Andrew W. Buesking , Richard B. Sparks , Eddy W. Yue
IPC分类号: C07D487/04 , C07D519/00
CPC分类号: C07D487/04 , C07D519/00
摘要: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
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公开(公告)号:US12006320B2
公开(公告)日:2024-06-11
申请号:US17356986
申请日:2021-06-24
申请人: Incyte Corporation
发明人: Stacey Shepard , Yanran Ai , Andrew P. Combs , Nikoo Falahatpisheh , Lixin Shao , Artem Shvartsbart
IPC分类号: A61K31/4985 , A61K31/53 , A61P9/00 , A61P25/00 , A61P35/00 , A61P37/00 , C07D407/04 , C07D487/04 , C07D519/00
CPC分类号: C07D487/04 , C07D519/00
摘要: This application relates to compounds of Formula (I):
or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
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