公开(公告)号：US11926630B2

公开(公告)日：2024-03-12

申请号：US17537674

申请日：2021-11-30

申请人： Incyte Corporation

发明人： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P25/28

CPC分类号： C07D487/04 ,  A61P25/28 ,  A61P35/00 ,  C07B2200/07 ,  C07B2200/13

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11046658B2

公开(公告)日：2021-06-29

申请号：US16458530

申请日：2019-07-01

申请人： Incyte Corporation

发明人： Brent Douty ,  Yanran Ai ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Eddy W. Yue ,  Andrew W. Buesking

IPC分类号： C07D241/20 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D471/06 ,  C07D487/04

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11919908B2

公开(公告)日：2024-03-05

申请号：US17555768

申请日：2021-12-20

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Onur Atasoylu ,  Cheng-Tsung Lai ,  Padmaja Polam ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： C07D487/04

摘要： The present application provides deazaguaine compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20220213108A1

公开(公告)日：2022-07-07

申请号：US17555768

申请日：2021-12-20

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Onur Atasoylu ,  Cheng-Tsung Lai ,  Padmaja Polam ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D487/04

摘要： The present application provides deazaguaine compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20240228498A1

公开(公告)日：2024-07-11

申请号：US18430528

申请日：2024-02-01

申请人： Incyte Corporation

发明人： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61P25/28 ,  A61P35/00 ,  C07B2200/07 ,  C07B2200/13

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20230226040A1

公开(公告)日：2023-07-20

申请号：US17991482

申请日：2022-11-21

申请人： Incyte Corporation

发明人： Alejandro Amador Arjona ,  Angela Abdollahi ,  Margaret Favata ,  Jonathan Rios-Doria ,  Hui Wang ,  Susan Wee ,  Pei Gan ,  Jeffrey C. Yang ,  Yong Li ,  Le Zhao ,  Chunhong He ,  Chunyin Marshall Law ,  Wenyu Zhu ,  Xiaozhao Wang ,  Wenqing Yao ,  Peter Niels Carlsen ,  Fenglei Zhang ,  Qinda Ye ,  Matthew S. McCammant ,  Rocco Policarpo ,  Artem Shvartsbart ,  Jeremy Roach ,  Gia Hoang ,  Bin Hu ,  Gencheng Li ,  Robert Susick ,  Padmaja Polam ,  Chao Qi ,  Alexander Sokolsky ,  Haolin Yin ,  Chang Min

IPC分类号： A61K31/4745 ,  A61P35/00 ,  A61P11/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K45/06

CPC分类号： A61K31/4745 ,  A61P35/00 ,  A61P11/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/498 ,  A61K31/506 ,  A61K45/06

摘要： The present disclosure relates to methods of treating cancer by administering a compound, which is a Fibroblast Growth Factor Receptor (FGFR) inhibitor, in combination with a Kirsten rat sarcoma (KRAS) inhibitor.

公开(公告)号：US20220213107A1

公开(公告)日：2022-07-07

申请号：US17537674

申请日：2021-11-30

申请人： Incyte Corporation

发明人： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P25/28

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11306079B2

公开(公告)日：2022-04-19

申请号：US16955240

申请日：2018-12-20

申请人： Incyte Corporation

发明人： Artem Shvartsbart ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard

IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D403/04 ,  C07D403/14 ,  C07D401/14 ,  C07D493/08 ,  C07D487/08 ,  C07D413/04

摘要： This application relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11225486B2

公开(公告)日：2022-01-18

申请号：US16913488

申请日：2020-06-26

申请人： Incyte Corporation

发明人： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P25/28

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20210269434A1

公开(公告)日：2021-09-02

申请号：US17144374

申请日：2021-01-08

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Wenyu Zhu ,  Jeffrey Yang ,  Alexander Sokolsky ,  Chunhong He ,  Zhenwu Li ,  Chao Qi ,  Yong Li ,  Pei Gan ,  Peter Carlsen ,  Gia Hoang ,  Heeoon Han ,  Chenyin Marshall Law ,  Fenglei Zhang ,  Padmaja Polam ,  Le Zhao ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D519/00 ,  C07D471/14

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.