公开(公告)号：US11738144B2

公开(公告)日：2023-08-29

申请号：US17935483

申请日：2022-09-26

Applicant: INSULET CORPORATION

Inventor： Joon Bok Lee ,  Bonnie Dumais ,  Jason O'Connor ,  Yibin Zheng

IPC: A61M5/172 ,  A61M5/142

CPC classification number: A61M5/1723 ,  A61M5/14244 ,  A61M2230/201

Abstract: Disclosed are techniques and devices that are operable to receive one or a number of generalized parameters of an automated insulin delivery algorithm. An input of at least one generalized parameter corresponding to a user may be used to set one or more of the number of specific parameters of the automated insulin delivery algorithm based on the inputted at least one generalized parameter. Physiological condition data related to the user may be collected. The automated insulin delivery algorithm may determine a dosage of insulin to be delivered based on the collected physiological condition. Signals may be output to cause a liquid drug to be delivered to the user based on an output of the automated insulin delivery algorithm related to the determined dosage of insulin.

公开(公告)号：US11684716B2

公开(公告)日：2023-06-27

申请号：US16945246

申请日：2020-07-31

Applicant: Insulet Corporation

Inventor： Yibin Zheng ,  Joon Bok Lee ,  Jason O'Connor

IPC: A61M5/172 ,  A61M5/142 ,  A61K38/28 ,  G16H20/17 ,  G16H40/67 ,  G05D7/06 ,  G05B15/02

CPC classification number: A61M5/172 ,  A61K38/28 ,  A61M5/14248 ,  G05B15/02 ,  G05D7/0623 ,  G05D7/0676 ,  G16H20/17 ,  G16H40/67 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3584 ,  A61M2205/52

Abstract: Disclosed are techniques to establish a modified pump rate that mitigates the effects of a pump occlusion and enables a recommended dosage of insulin to be output by a pump mechanism over the course of a control cycle. In an example, the pump rate may be reduced by adding a calculated time interval between application of actuation commands to extend the amount of time over which insulin may be output by the pump mechanism.

公开(公告)号：US11565043B2

公开(公告)日：2023-01-31

申请号：US16402753

申请日：2019-05-03

Applicant: Insulet Corporation

Inventor： Jason O'Connor ,  Joon Bok Lee ,  Trang Ly ,  Yibin Zheng ,  Thomas Arnold Peyser ,  Jennifer Lena Schneider

IPC: G08B21/04 ,  A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  A61M5/145 ,  A61B5/00

Abstract: Disclosed are a system, methods and computer-readable medium products that provide safety constraints for an insulin-delivery management program. Various examples provide safety constraints for a control algorithm-based drug delivery system that provides automatic delivery of a drug based on sensor input. Glucose measurement values may be received at regular time intervals from a sensor. A processor may predict future glucose values based on prior glucose measurement values. The safety constraints assist in safe operation of the drug delivery system during various operational scenarios. In some examples, predicted future glucose values may be used to implement safety constraints that mitigate under-delivery or over-delivery of the drug while not overly burdening the user of the drug delivery system and without sacrificing performance of the drug delivery system. Other safety constraints are also disclosed.

公开(公告)号：US20220331520A1

公开(公告)日：2022-10-20

申请号：US17723778

申请日：2022-04-19

Applicant: Insulet Corporation

Inventor： Joon Bok Lee ,  Yibin Zheng ,  Jason O'Connor

IPC: A61M5/172 ,  A61M5/142

Abstract: Disclosed are a system, a device, processes, techniques and computer-readable media that set an insulin adjustment factor that is applied to a dose of a therapeutic exogenous substance. The adjustment factor accounts for production of endogenous insulin related to the therapeutic exogenous substance. A processor of an automatic drug delivery device may determine and administer the doses of the therapeutic exogenous substance according to a process in which an amount of a therapeutic exogenous substance to deliver is estimated. An insulin adjustment factor utilizing an estimated relative therapeutic exogenous substance concentration may be determined. The processor may calculate a compensating dose of the therapeutic exogenous substance based on the estimated amount of the therapeutic exogenous substance to deliver that is modified by the insulin adjustment factor. The compensating dose of the therapeutic exogenous substance may be expelled from a reservoir by a pump mechanism.

公开(公告)号：US11383035B1

公开(公告)日：2022-07-12

申请号：US17539270

申请日：2021-12-01

Applicant: Insulet Corporation

Inventor： Joon Bok Lee ,  Yibin Zheng ,  Jason O'Connor ,  Ashutosh Zade

IPC: A61M5/172 ,  A61M5/142 ,  G16H20/17

Abstract: Disclosed herein is a method for execution by a drug delivery device for determining an optimal dose of a liquid drug for current cycle of a medication delivery algorithm, the method utilizing a stepwise evaluation of a model and a cost function across a coarse search space consisting of coarse discrete quantities of the drug and a refined search space consisting of refined discrete quantities of the drug.