公开(公告)号：US20100280006A1

公开(公告)日：2010-11-04

申请号：US12387946

申请日：2009-05-08

Applicant: James C. Sutton ,  Marion Wiesmann ,  Weibo Wang ,  Mika Lindvall ,  Jiong Lan ,  Savithri Ramurthy ,  Anu Sharma ,  Elizabeth J. Mieuli ,  Liana M. Klivansky ,  William Lenahan ,  Susan Kaufman ,  Hong Yang ,  Simon C. Ng ,  Keith Pfister ,  Allan S. Wagman ,  Victoria Sung ,  Martin Sendzik

Inventor： James C. Sutton ,  Marion Wiesmann ,  Weibo Wang ,  Mika Lindvall ,  Jiong Lan ,  Savithri Ramurthy ,  Anu Sharma ,  Elizabeth J. Mieuli ,  Liana M. Klivansky ,  William Lenahan ,  Susan Kaufman ,  Hong Yang ,  Simon C. Ng ,  Keith Pfister ,  Allan S. Wagman ,  Victoria Sung ,  Martin Sendzik

IPC: A61K31/55 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4709 ,  A61K31/437 ,  A61K31/428 ,  A61K31/506 ,  A61P35/02 ,  A61P35/00 ,  A61P19/02 ,  A61P29/00 ,  A61P19/10 ,  A61P9/10 ,  A61P43/00 ,  C12N5/02

CPC classification number: C07D413/12 ,  C07D417/12

Abstract: Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

Abstract translation: 公开了苯并恶唑和苯并噻唑化合物及其立体异构体，互变异构体，溶剂合物，氧化物，酯和前药及其药学上可接受的盐。 还公开了单独或与至少一种另外的治疗剂组合的化合物与药学上可接受的载体的组合，以及化合物单独或与至少一种另外的治疗剂组合的用途。 这些实施方案可用于抑制细胞增殖，抑制肿瘤的生长和/或复分解，治疗或预防癌症，治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF-1R。

公开(公告)号：US07772267B2

公开(公告)日：2010-08-10

申请号：US11931282

申请日：2007-10-31

Applicant: Chong-qing Sun ,  Lawrence Hamann ,  David Augeri ,  Yingzhi Bi ,  Jeffrey Robl ,  Yan-Ting Huang ,  Tammy Wang ,  Alexandra Holubec ,  Ligaya Simpkins ,  James C. Sutton ,  James J. Li

Inventor： Chong-qing Sun ,  Lawrence Hamann ,  David Augeri ,  Yingzhi Bi ,  Jeffrey Robl ,  Yan-Ting Huang ,  Tammy Wang ,  Alexandra Holubec ,  Ligaya Simpkins ,  James C. Sutton ,  James J. Li

IPC: A61K31/415 ,  C07D235/02

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.

Abstract translation: 提供根据式I的化合物，其中取代基如本文所述。 进一步提供的是使用这些化合物来治疗核激素受体相关病症的方法，例如年龄相关疾病，例如肌肉减少症。 还提供了含有这些化合物的药物组合物和制备本发明的一些化合物的方法。 还公开了其他实施例。

公开(公告)号：US07714002B2

公开(公告)日：2010-05-11

申请号：US11474841

申请日：2006-06-26

Applicant: James C. Sutton

Inventor： James C. Sutton

IPC: A61K31/44 ,  C07D213/69 ,  C07D213/74

CPC classification number: C07D213/74 ,  C07D213/69

Abstract: The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.

Abstract translation: 本发明提供新的尿素模拟物和式（I）的类似物：或其立体异构体，互变异构体，药学上可接受的盐或溶剂化物形式，其中变量A，B，W和R6如本文所定义。 这些化合物是可用作药物的人P2Y1受体的选择性抑制剂。

公开(公告)号：US07645778B2

公开(公告)日：2010-01-12

申请号：US11333050

申请日：2006-01-17

Applicant: James C. Sutton ,  Zulan Pi ,  Rejean Ruel ,  Alexandre L'Heureux ,  Carl Thibault ,  Patrick Y. S. Lam

Inventor： James C. Sutton ,  Zulan Pi ,  Rejean Ruel ,  Alexandre L'Heureux ,  Carl Thibault ,  Patrick Y. S. Lam

IPC: A61K31/4436 ,  C07D417/12

CPC classification number: C07D213/74 ,  C07D213/75 ,  C07D213/80 ,  C07D277/42 ,  C07D277/56 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.

Abstract translation: 本发明提供了新的杂芳基化合物及其类似物，它们是人P2Y1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。

公开(公告)号：US07405234B2

公开(公告)日：2008-07-29

申请号：US10780415

申请日：2004-02-17

Applicant: Chong-Qing Sun ,  Lawrence Hamann ,  David Augeri ,  Yingzhi Bi ,  Jeffrey Robl ,  Yan-Ting Huang ,  Tammy Wang ,  Alexandra Holubec ,  Ligaya Simpkins ,  James C. Sutton ,  James J. Li

Inventor： Chong-Qing Sun ,  Lawrence Hamann ,  David Augeri ,  Yingzhi Bi ,  Jeffrey Robl ,  Yan-Ting Huang ,  Tammy Wang ,  Alexandra Holubec ,  Ligaya Simpkins ,  James C. Sutton ,  James J. Li

IPC: A61K31/415 ,  C07D235/02

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

Abstract translation: 本发明提供式I化合物，其中取代基如本文所述。 进一步提供的是使用这些化合物来治疗核激素受体相关病症的方法，例如年龄相关疾病，例如肌肉减少症。 还提供了含有这些化合物的药物组合物和制备本发明的一些化合物的方法。