公开(公告)号：US06719789B2

公开(公告)日：2004-04-13

申请号：US10153286

申请日：2002-05-21

申请人： James L. Cox

发明人： James L. Cox

IPC分类号： A61F206

CPC分类号： A61L27/3843 ,  A61F2/0095 ,  A61F2/2412 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/507 ,  A61L2430/20 ,  G06Q40/04 ,  Y10S623/90 ,  Y10S623/901

摘要： A prosthetic heart valve has leaflets made of a thin and flexible material. The side edges of adjacent leaflets are sewn together so as to form a substantially tubular valve structure having an in-flow end and an out-flow end. Each of the leaflets is adapted to flex inwardly into and out of engagement with another leaflet so as to close and open the valve in response to force by blood pressure. The leaflets are configured so that a portion of the inner face of each leaflet is in a facing relationship with a portion of the inner face of an adjacent leaflet.

摘要翻译： 假体心脏瓣膜具有由薄且柔性材料制成的传单。 相邻小叶的侧边缘被缝合在一起，以形成具有流入端和流出端的基本管状的阀结构。 每个小叶适于向内弯曲和/或不与另一个小叶接合，以便响应于血压的力而关闭和打开瓣膜。 小叶被配置成使得每个小叶的内表面的一部分与相邻小叶的内表面的一部分面对关系。

公开(公告)号：US06719788B2

公开(公告)日：2004-04-13

申请号：US10153290

申请日：2002-05-21

申请人： James L. Cox

发明人： James L. Cox

IPC分类号： A61F206

CPC分类号： A61L27/3843 ,  A61F2/0095 ,  A61F2/2412 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/507 ,  A61L2430/20 ,  G06Q40/04 ,  Y10S623/90 ,  Y10S623/901

摘要： A replacement heart valve is configured to replace a native atrioventricular heart valve (mitral or tricuspid valve, positioned between an atrial chamber and a ventricular chamber). The replacement valve includes a a thin and flexible wall portion having no more than two leaflets. Two securement locations adjacent the outlet end of the valve are adapted to be attached to respective papillary muscles. The unconstrained regions between the securement locations flex inwardly into and out of engagement with each other in response to blood pressure in order to close and open the valve. The leaflets engage each other along a line of commissure.

摘要翻译： 置换心脏瓣膜被配置为替代原位房室心脏瓣膜（二尖瓣或三尖瓣，位于心房和心室之间）。 替换阀包括具有不超过两个传单的薄且柔性的壁部分。 邻近阀门出口端的两个固定位置适于连接到相应的乳头肌。 固定位置之间的无约束区域响应于血压而向内进入和离开接合以便关闭和打开阀。 传单沿着一连串的关系彼此相互接触。

公开(公告)号：US06719787B2

公开(公告)日：2004-04-13

申请号：US10121208

申请日：2002-04-11

申请人： James L. Cox

发明人： James L. Cox

IPC分类号： A61F206

CPC分类号： A61L27/3843 ,  A61F2/0095 ,  A61F2/2412 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/507 ,  A61L2430/20 ,  G06Q40/04 ,  Y10S623/90 ,  Y10S623/901

摘要： A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either “tacked” at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, comprising a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape. The synthetic tube is packaged within a sealed watertight enclosure that maintains sterility of the tube.

摘要翻译： 公开了一种用于使用管状材料来代替半月瓣心脏瓣膜（即主动脉瓣或肺动脉瓣）的方法。 为了创建这样的替换阀，从主动脉或肺动脉内部移除天然瓣膜，并将管状区段的入口端缝合到瓣膜环。 管的出口（远端）在三个点处“向上”，或沿三条线纵向缝合; 任何一种方法将允许缝合线之间的组织襟翼起到可移动的尖角的作用。 这种方法产生减少湍流的流动模式并且紧密地重复天然半月形阀的流动模式。 还公开了一种制造物品，其包括以管状形式制造的无菌生物相容性合成材料，通过诸如挤出或涂覆圆柱形模制装置的方法，以避免需要缝合线或其它接缝以将平板 的材料变成管状。 合成管包装在密封的防水外壳内，保持管的无菌性。

公开(公告)号：US06565603B2

公开(公告)日：2003-05-20

申请号：US09776124

申请日：2001-02-02

申请人： James L. Cox

发明人： James L. Cox

IPC分类号： A61F206

CPC分类号： A61F2/2448 ,  Y10S623/904

摘要： A mitral valve annuloplasty ring and method for implanting a mitral valve annuloplasty ring to treat mitral insufficiency by reestablishing the normal shape and contour of the mitral valve annulus. The annuloplasty ring is flexible and can be readily adjusted to different sizes and shapes. The method substantially eliminates scarring subsequent to the annuloplasty procedure to maintain flexibility of the ring and the annulus indefinitely.

摘要翻译： 二尖瓣瓣环成形术环和植入二尖瓣环成形术环以通过重建二尖瓣环的正常形状和轮廓来治疗二尖瓣功能不全的方法。 瓣环成形术环是柔性的并且可以容易地调节到不同的尺寸和形状。 该方法基本上消除了环形成形术之后的瘢痕形成，以便无限期地保持环和环的柔性。

公开(公告)号：US6092529A

公开(公告)日：2000-07-25

申请号：US288998

申请日：1999-02-03

申请人： James L. Cox

发明人： James L. Cox

IPC分类号： A61F2/00 ,  A61F2/24 ,  A61L27/36 ,  G06Q40/04

CPC分类号： A61L27/3843 ,  A61F2/0095 ,  A61F2/2412 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/507 ,  G06Q40/04 ,  A61L2430/20 ,  Y10S623/90 ,  Y10S623/901

摘要： A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either "tacked" at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, including a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape. The synthetic tube is packaged within a sealed watertight enclosure that maintains sterility of the tube.

摘要翻译： 公开了一种用于使用管状材料来代替半月瓣心脏瓣膜（即主动脉瓣或肺动脉瓣）的方法。 为了创建这样的替换阀，从主动脉或肺动脉内部移除天然瓣膜，并将管状区段的入口端缝合到瓣膜环。 管的出口（远端）在三个点处“向上”，或沿三条线纵向缝合; 任何一种方法将允许缝合线之间的组织襟翼起到可移动的尖角的作用。 这种方法产生减少湍流的流动模式并且紧密地重复天然半月形阀的流动模式。 还公开了一种制造物品，其包括以管状形式制造的无菌生物相容性合成材料，通过诸如挤出或涂覆圆柱形模制装置的方法，以避免需要缝合线或其它接缝以将平板 的材料变成管状。 合成管包装在密封的防水外壳内，保持管的无菌性。

公开(公告)号：US5824063A

公开(公告)日：1998-10-20

申请号：US749335

申请日：1996-11-14

申请人： James L. Cox

发明人： James L. Cox

IPC分类号： A61F2/00 ,  A61F2/24 ,  A61L27/36 ,  G06Q40/04

CPC分类号： A61L27/3843 ,  A61F2/0095 ,  A61F2/2412 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/507 ,  G06Q40/04 ,  A61L2430/20 ,  Y10S623/90 ,  Y10S623/901

摘要： This invention comprises a method of using tubular material to replace an atrioventricular (AV) heart valve (i.e., a mitral or tricuspid valve, positioned between an atrial chamber and a ventricular chamber) during cardiac surgery. Preferably, the tubular material should be inherently tubular; i.e., it should be created in tubular form from its inception, rather than by using a longitudinal suture line or other seam to convert a flat sheet of material into a tubular shape. Suitable tubular materials include (1) biocompatible synthetic materials which are manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, using material which is sufficiently thin and flexible to serve as leaflets in AV heart valves; and (2) a segment of submucosal tissue harvested from a small intestine, either from the patient who is undergoing the cardiac surgery, or from an animal or human cadaver if the harvested tissue is properly treated to reduce antigenicity. To create a replacement AV valve, the inlet of the tubular segment is sutured to the mitral or tricuspid valve annulus, after the native valve leaflets have been removed. The outlet end of the tube is trimmed or sculpted into leaflets, and the distal ends of the leaflets are sutured to papillary muscles in the ventricle, in a manner which causes the leaflets to "approximate" (close together), during systolic contraction of the heart, in a configuration that resembles the line of commissure created by healthy native leaflets. This generates flow patterns that closely duplicate the flow patterns of native AV valves.

摘要翻译： 本发明包括在心脏手术期间使用管状材料来替代房室（AV）心脏瓣膜（即位于心房和心室之间的二尖瓣或三尖瓣）的方法。 优选地，管状材料应当是固有的管状的; 即它应该从其初始形成为管状形式，而不是通过使用纵向缝合线或其它接缝将平坦的材料片转换成管状形状。 合适的管状材料包括（1）以管状形式制造的生物相容合成材料，通过诸如挤出或涂覆圆柱形模制装置的方法，使用足够薄且柔性的材料用作AV心脏瓣膜中的小叶; 和（2）从正在进行心脏手术的患者的小肠收获的一段粘膜下组织，或者如果收获的组织被适当地处理以降低抗原性，则来自动物或人类尸体。 为了创建替代的AV瓣膜，将管状部分的入口缝合到二尖瓣或三尖瓣瓣环，在移除本地瓣膜后。 管的出口端被修剪或雕刻成小叶，并且传播的远端被缝合到心室的乳头肌，以使得传单在收缩期收缩期间“近似”（靠近在一起）的方式 心脏，在类似于由健康的本地传单创建的连合线的配置中。 这产生与本地AV阀的流动模式紧密重复的流动模式。

公开(公告)号：US5713950A

公开(公告)日：1998-02-03

申请号：US459979

申请日：1995-06-02

申请人： James L. Cox

发明人： James L. Cox

IPC分类号： A61F2/00 ,  A61F2/24 ,  A61L27/36 ,  G06Q40/04

CPC分类号： A61L27/3843 ,  A61F2/0095 ,  A61F2/2412 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/507 ,  G06Q40/04 ,  A61L2430/20 ,  Y10S623/90 ,  Y10S623/901

摘要： This invention comprises a method of using tubular material to replace a heart valve during cardiac surgery. To create a replacement atrioventricular (mitral or tricuspid) valve, the tube inlet is sutured to a valve annulus from which the native leaflets have been removed, and the tube outlet is sutured to papillary muscles in the ventricle. To create a semilunar (aortic or pulmonary) valve, the tube inlet is sutured to an annulus from which the native cusps have been removed, and the tube is either "tacked" at three points distally inside the artery, or sutured longitudinally along three lines; this allows the flaps of tissue between the three fixation points at the valve outlet to function as movable cusps. These approaches generate flow patterns that closely duplicate the flow patterns of native valves. One preferred tubular material comprises submucosal tissue from a small intestine, from the same patient who is undergoing the cardiac operation; this eliminates the risk of immune rejection and the need to treat the tissue to reduce antigenicity. Intestinal tissue from human cadavers or animals such as genetically engineered hypoallergenic pigs can also be used, if properly treated, or a biocompatible synthetic tubular material can be used.

摘要翻译： 本发明包括在心脏手术期间使用管状材料来代替心脏瓣膜的方法。 为了创建替代房室（二尖瓣或三尖瓣）阀，将管入口缝合到已经被去除天然小叶的瓣膜环，并将管出口缝合到心室的乳头肌。 为了创建一个半月（主动脉或肺动脉）瓣膜，将管入口缝合到已经被去除天然尖端的环形区域，并且该管子在动脉内部的远端的三个点处被“粘结”，或沿三条线纵向缝合 ; 这允许在阀出口处的三个固定点之间的组织瓣可用作可移动的尖头。 这些方法产生与本机阀的流动模式密切相反的流动模式。 一种优选的管状材料包括来自正在进行心脏手术的同一患者的来自小肠的粘膜下组织; 这消除了免疫排斥的风险，并且需要治疗组织以降低抗原性。 也可以使用来自人类尸体或动物如遗传工程化低变应原性猪的肠组织，如果适当处理，或可使用生物相容的合成管状材料。

公开(公告)号：US5687737A

公开(公告)日：1997-11-18

申请号：US331752

申请日：1994-10-31

申请人： Barry H. Branham ,  James L. Cox ,  John P. Boineau ,  Richard B. Schuessler

发明人： Barry H. Branham ,  James L. Cox ,  John P. Boineau ,  Richard B. Schuessler

IPC分类号： A61B5/042 ,  A61B5/044

CPC分类号： A61B5/0422 ,  A61B2562/0209 ,  A61B2562/046 ,  A61B2562/164

摘要： An optimal electrophysiologic mapping system for map-directed arrhythmia surgery and cardiac research allows rapid and accurate interpretation of cardiac activation sequences. The system can display activation or potential distribution data on an anatomically accurate 3-D model of the heart and allows fast, interactive control of viewing characteristics, including control of which cardiac surfaces are displayed, control of virtual lighting, rotational control of the displayed image, etc. The system employs two computer programs, GETPIC3 and MAP3, and runs on a Silicon Graphics workstation capable of rapid graphics calculations and displays. The system utilizes 3-D models of epicardial and endocardial surfaces created with the GETPIC3 program from a sequence of 2-D images of a heart. The individual surfaces are triangulated and may be smoothed using a spline function. The MAP3 program displays activation times either as static isochronous maps or as dynamic time-since-last-activation maps. In the latter case, surface color denotes the time elapsed since a particular area activated. Potential distribution data may also be displayed dynamically. A mouse allows the system operator to control real-time rotation of the model in three dimensions, and any surface can be hidden interactively for better viewing of the data. Control is also provided over the starting, stopping, reversing, and repeating of data, as well as over the frame rate for dynamic displays.

摘要翻译： 用于地图导向心律失常手术和心脏研究的最佳电生理映射系统可以快速准确地解释心脏激活序列。 该系统可以在心脏的解剖学上精确的3-D模型上显示激活或潜在的分布数据，并允许对观看特征的快速，交互式控制，包括显示哪个心脏表面的控制，虚拟照明的控制，显示图像的旋转控制 等等。该系统采用两个计算机程序GETPIC3和MAP3，并运行在能够快速图形计算和显示的Silicon Graphics工作站上。 该系统利用由心脏的2-D图像序列用GETPIC3程序创建的心脏和心内膜表面的3D模型。 各个表面被三角测量，并可以使用样条函数进行平滑处理。 MAP3程序显示激活时间作为静态等时图或动态时间自上次激活映射。 在后一种情况下，表面颜色表示从特定区域激活以来经过的时间。 潜在分布数据也可以动态显示。 鼠标允许系统操作员以三维方式控制模型的实时旋转，并且任何表面可以被交互地隐藏以更好地观看数据。 还提供数据的启动，停止，反转和重复以及动态显示的帧速率的控制。