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公开(公告)号：US20090247481A1
公开(公告)日：2009-10-01
申请号：US12477105
申请日：2009-06-02
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： A61K31/708
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
摘要翻译： 提供组合物，试剂盒和方法用于治疗或预防流行性感冒。
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公开(公告)号：US08741343B2
公开(公告)日：2014-06-03
申请号：US12959321
申请日：2010-12-02
申请人： Gregory T. Went , Gayatri Sathyan , Kavita Vermani , Gangadhara Ganapati , Michael Coffee , Efraim Shek , Ashok Katdare
发明人： Gregory T. Went , Gayatri Sathyan , Kavita Vermani , Gangadhara Ganapati , Michael Coffee , Efraim Shek , Ashok Katdare
CPC分类号： A61K31/13 , A61K9/0002 , A61K9/0004 , A61K9/0053 , A61K9/14 , A61K9/48 , A61K9/4808 , A61K9/4891 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K31/198
摘要： Methods of nighttime administration of amantadine to reduce sleep disturbances in patient undergoing treatment with amantadine are described, as well as compositions of extended release amantadine that are suitable for nighttime administration.
摘要翻译： 描述了夜间施用金刚烷胺以减少用金刚烷胺治疗的患者的睡眠障碍的方法，以及适用于夜间给药的延长释放金刚烷胺的组合物。
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公开(公告)号：US20120288560A1
公开(公告)日：2012-11-15
申请号：US13559478
申请日：2012-07-26
IPC分类号： A61K31/445 , A61K9/48 , A61P25/16 , A61P25/00 , A61P25/28
CPC分类号： A61K9/2054 , A61K9/0053 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2059 , A61K9/2813 , A61K9/282 , A61K9/48 , A61K9/4808 , A61K9/7061 , A61K31/13 , A61K31/445 , A61K45/06 , A61K2300/00 , Y02A50/401
摘要： The invention provides methods for treating CNS-related conditions with amantadine and donepezil, in which the amantadine is in an extended release form, wherein the extended release amantadine formulation provides a change in plasma concentration as a function of time (dC/dT) that is less than 40% of the dC/dT of the same quantity of an immediate release form of amantadine.
摘要翻译： 本发明提供了用金刚胺和多奈哌齐来处理CNS相关病症的方法，其中金刚烷胺为延长释放形式，其中延长释放金刚烷胺制剂提供作为时间（dC / dT）的函数的血浆浓度变化，其为 少于dC / dT的相同量的立即释放形式的金刚烷胺的40％。
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公开(公告)号：US20120264829A1
公开(公告)日：2012-10-18
申请号：US13536525
申请日：2012-06-28
CPC分类号： A61K31/13 , A61K9/4891 , Y10S514/964
摘要： The invention provides methods for administering memantine to a subject. Memantine in an extended release form containing 22.5 to 30 mg memantine or a pharmaceutically acceptable salt is administered to a patient suffering from a neurological condition, such as Alzheimer's disease, Parkinson's disease or dementia. The extended release form achieves particular pharmacokinetic criteria such as change in plasma concentration of memantine over time and ratio of maximum memantine plasma concentration to mean memantine plasma concentration.
摘要翻译： 本发明提供了向受试者施用美金刚的方法。 将含有22.5至30mg美金刚或药学上可接受的盐的延长释放形式的美金刚给予患有神经病症如阿尔茨海默病，帕金森病或痴呆的患者。 延长释放形式达到特定的药物动力学标准，例如美金刚的血浆浓度随时间的变化和最大美金刚血浆浓度与平均美金刚血浆浓度的比例。
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公开(公告)号：US08283379B2
公开(公告)日：2012-10-09
申请号：US12757795
申请日：2010-04-09
CPC分类号： A61K9/2054 , A61K9/0053 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2059 , A61K9/2813 , A61K9/282 , A61K9/48 , A61K9/4808 , A61K9/7061 , A61K31/13 , A61K31/445 , A61K45/06 , Y02A50/401 , A61K2300/00
摘要： The present invention provides novel methods and compositions for the treatment and prevention of CNS-related conditions. One of the CNS-related conditions treated by the methods and compositions of the invention is Alzheimer's disease.
摘要翻译： 本发明提供了用于治疗和预防CNS相关病症的新方法和组合物。 通过本发明的方法和组合物治疗的CNS相关病症之一是阿尔茨海默氏病。
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公开(公告)号：US08168209B2
公开(公告)日：2012-05-01
申请号：US12512701
申请日：2009-07-30
CPC分类号： A61K31/13 , A61K9/4891 , Y10S514/964
摘要： The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject.
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公开(公告)号：US08058291B2
公开(公告)日：2011-11-15
申请号：US11399879
申请日：2006-04-06
申请人： Gregory T. Went , Timothy J. Fultz
发明人： Gregory T. Went , Timothy J. Fultz
IPC分类号： A01N43/40 , A01N27/00 , A01N37/06 , A61K31/445 , A61K31/015 , A61K31/22 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00
CPC分类号： A61K9/2054 , A61K9/0053 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2059 , A61K9/2813 , A61K9/282 , A61K9/48 , A61K9/4808 , A61K9/7061 , A61K31/13 , A61K31/445 , A61K45/06 , Y02A50/401 , A61K2300/00
摘要： The present invention provides novel methods and compositions for the treatment and prevention of CNS-related conditions. One of the CNS-related conditions treated by the methods and compositions of the invention is Alzheimer's disease.
摘要翻译： 本发明提供了用于治疗和预防CNS相关病症的新方法和组合物。 通过本发明的方法和组合物治疗的CNS相关病症之一是阿尔茨海默氏病。
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公开(公告)号：US07981930B2
公开(公告)日：2011-07-19
申请号：US12040856
申请日：2008-02-29
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： A61K31/7056 , A61K31/351 , A61K31/215 , A61K31/196 , A61K31/195 , A61K31/131 , C07H19/056 , C07D309/28 , C07C69/75 , C07C61/22 , C07C229/48 , C07C211/38
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Kits comprising an M2 inhibitor selected from amantadine and rimantadine; ribavirin, and a neuraminidase inhibitor (NAi) in an amount that is antivirally effective in the combination, an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin and a neuraminidase inhibitor are provided for the treatment of influenza. Some embodiments of the kits comprise an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin, and a neuraminidase inhibitor.
摘要翻译： 包含选自金刚胺和金刚乙胺的M2抑制剂的试剂盒; 利巴韦林和神经氨酸酶抑制剂（NAi），其组合中具有抗病毒效果的量，含有75-250mg的M2抑制剂的口服剂型，包含100-400mg的利巴韦林和神经氨酸酶抑制剂的口服剂型为 规定用于治疗流行性感冒。 试剂盒的一些实施方案包括含有75-250mg的M2抑制剂的口服剂型，包含100-400mg的利巴韦林的口服剂型和神经氨酸酶抑制剂。
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公开(公告)号：US20100029665A1
公开(公告)日：2010-02-04
申请号：US12420790
申请日：2009-04-08
IPC分类号： A61K31/13 , A61K31/138 , A61K31/437 , A61K31/404 , A61K31/403 , A61K31/4985 , A61P25/06
CPC分类号： A61K31/55 , A61K31/13 , A61K31/137 , A61K31/138 , A61K31/275 , A61K31/404 , A61K31/405 , A61K31/445 , A61K31/48 , A61K31/485 , A61K31/56 , A61K31/57 , A61K38/4886 , A61K45/06 , A61K2300/00
摘要： The present invention provides novel methods and compositions for the treatment and prevention of headaches, vascular headaches, migraine headaches, cluster headaches, and migraine. One of the headaches, vascular headaches, migraine headaches, cluster headaches, and migraine treated by the methods and compositions of the invention is migraine.
摘要翻译： 本发明提供用于治疗和预防头痛，血管性头痛，偏头痛，丛集性头痛和偏头痛的新颖方法和组合物。 通过本发明的方法和组合物治疗的头痛，血管性头痛，偏头痛，丛集性头痛和偏头痛之一是偏头痛。
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30.发明申请Methods and compositions for the treatment of epilepsy, seizure disorders, and other CNS disorders 审中-公开用于治疗癫痫，癫痫发作障碍和其他CNS疾病的方法和组合物公开(公告)号：US20090306051A1
公开(公告)日：2009-12-10
申请号：US12333121
申请日：2008-12-11
IPC分类号： A61K31/35 , A61K31/5513 , A61K31/133 , A61K31/55 , A61K31/195 , A61K31/53 , A61K31/22 , A61K31/423 , A61P25/08
CPC分类号： A61K31/53 , A61K31/13 , A61K31/131 , A61K31/136 , A61K31/137 , A61K31/195 , A61K31/39 , A61K31/423 , A61K31/55 , A61K31/7008 , A61K31/7048 , A61K45/06 , Y02A50/401 , A61K2300/00
摘要： The present invention relates to methods and compositions for treating CNS-related disorders.
摘要翻译： 本发明涉及用于治疗CNS相关疾病的方法和组合物。
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