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公开(公告)号：US07981930B2
公开(公告)日：2011-07-19
申请号：US12040856
申请日：2008-02-29
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： A61K31/7056 , A61K31/351 , A61K31/215 , A61K31/196 , A61K31/195 , A61K31/131 , C07H19/056 , C07D309/28 , C07C69/75 , C07C61/22 , C07C229/48 , C07C211/38
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Kits comprising an M2 inhibitor selected from amantadine and rimantadine; ribavirin, and a neuraminidase inhibitor (NAi) in an amount that is antivirally effective in the combination, an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin and a neuraminidase inhibitor are provided for the treatment of influenza. Some embodiments of the kits comprise an oral dosage form containing 75-250 mg of the M2 inhibitor, an oral dosage form comprising 100-400 mg of ribavirin, and a neuraminidase inhibitor.
摘要翻译： 包含选自金刚胺和金刚乙胺的M2抑制剂的试剂盒; 利巴韦林和神经氨酸酶抑制剂（NAi），其组合中具有抗病毒效果的量，含有75-250mg的M2抑制剂的口服剂型，包含100-400mg的利巴韦林和神经氨酸酶抑制剂的口服剂型为 规定用于治疗流行性感冒。 试剂盒的一些实施方案包括含有75-250mg的M2抑制剂的口服剂型，包含100-400mg的利巴韦林的口服剂型和神经氨酸酶抑制剂。
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公开(公告)号：US07858660B2
公开(公告)日：2010-12-28
申请号：US12477105
申请日：2009-06-02
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： C07H19/056 , A61K31/215 , A61K31/166 , A61K31/16 , A61K31/7056 , A61K31/13 , C07D315/00 , C07D307/12 , C07C69/75 , C07C61/08 , C07C217/52
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
摘要翻译： 提供组合物，试剂盒和方法用于治疗或预防流行性感冒。
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公开(公告)号：US20090326978A1
公开(公告)日：2009-12-31
申请号：US12495793
申请日：2009-06-30
申请人： Timothy J. Fultz , Gregory T. Went , Jack Nguyen , Paul Spence , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Timothy J. Fultz , Gregory T. Went , Jack Nguyen , Paul Spence , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
摘要： Stockpiles and methods of stockpiling a combination antiviral therapy for responding to an epidemic viral outbreak are described. Methods and systems of inventory control for co-deployment of drugs used in combination during a pandemic are described.
摘要翻译： 描述了储存组合抗病毒治疗以应对流行性病毒爆发的库存和方法。 描述了在大流行期间组合使用的药物共同部署的库存控制方法和系统。
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公开(公告)号：US20090247481A1
公开(公告)日：2009-10-01
申请号：US12477105
申请日：2009-06-02
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff , Terry L. Burkoth , Rowan Chapman , Mickey S. Urdea
IPC分类号： A61K31/708
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
摘要翻译： 提供组合物，试剂盒和方法用于治疗或预防流行性感冒。
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公开(公告)号：US20080227743A1
公开(公告)日：2008-09-18
申请号：US12040856
申请日：2008-02-29
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff
IPC分类号： A61K31/7056 , A61P31/12
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
摘要翻译： 提供组合物，试剂盒和方法用于治疗或预防流行性感冒。
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公开(公告)号：US20110230432A1
公开(公告)日：2011-09-22
申请号：US13116484
申请日：2011-05-26
申请人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff
发明人： Jack Nguyen , Gregory T. Went , Paul Spence , Timothy J. Fultz , David Chernoff
IPC分类号： A61K31/7056 , A61P31/16
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
摘要翻译： 提供组合物，试剂盒和方法用于治疗或预防流行性感冒。
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公开(公告)号：US20140242062A1
公开(公告)日：2014-08-28
申请号：US14275772
申请日：2014-05-12
IPC分类号： A61K38/48
CPC分类号： A61K38/482 , A61K38/49 , C07K2319/00 , C12N9/6421 , C12N9/6424 , C12N9/6467 , C12Y304/21109
摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.
摘要翻译： 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎症性疾病和具有炎性成分的疾病，包括阿尔茨海默病和其他神经变性疾病。
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公开(公告)号：US07939304B2
公开(公告)日：2011-05-10
申请号：US11104110
申请日：2005-04-12
申请人： Sandra Waugh Ruggles , Jack Nguyen
发明人： Sandra Waugh Ruggles , Jack Nguyen
IPC分类号： C12N9/00
CPC分类号： C12N9/6424 , A61K38/00 , C12Y304/21109
摘要： MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.
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公开(公告)号：US20060002916A1
公开(公告)日：2006-01-05
申请号：US11104110
申请日：2005-04-12
申请人： Sandra Ruggles , Jack Nguyen
发明人： Sandra Ruggles , Jack Nguyen
CPC分类号： C12N9/6424 , A61K38/00 , C12Y304/21109
摘要： MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.
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公开(公告)号：US10978887B2
公开(公告)日：2021-04-13
申请号：US16824070
申请日：2020-03-19
申请人： James Nguyen , Jack Nguyen
发明人： James Nguyen , Jack Nguyen
摘要： A fast charging battery system and method for charging battery systems can be applied to most battery types in use for electric vehicles (EVs), electronic devices, and wireless electrical machines. The system could employ industry proven battery charger systems and off-the-shelf electrical components (e.g., contactors, relay switches, semiconductor parts, DC-DC converters, and the like) to keep cost and complexity low. The system provides for two or more charging ports in the electronic device, such as an EV, that may be able to receive and recognize a charging type, such as charging voltage, current and the like, and provide directed charging to multiple battery sub-packs that make up the entire battery. By charging sub-packs in parallel, the charge time can be substantially reduced.
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