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21.发明申请Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli 有权用于引发针对杆菌的免疫应答的聚-γ-谷氨酸缀合物公开(公告)号：US20060134143A1
公开(公告)日：2006-06-22
申请号：US10559825
申请日：2004-06-04
申请人： Rachel Schneerson , Stephen Leppla , John Robbins , Joseph Shiloach , Joanna Kubler-Kielb , Darrell Liu , Fathy Majadly
发明人： Rachel Schneerson , Stephen Leppla , John Robbins , Joseph Shiloach , Joanna Kubler-Kielb , Darrell Liu , Fathy Majadly
CPC分类号： C07K14/32 , A61K39/00 , A61K39/07 , A61K47/646 , A61K2039/55516 , A61K2039/6031 , A61K2039/6037 , A61K2039/627
摘要： Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-γ-glutamic acid (γPGA) polypeptide of B. anthracis, or of another Bacillus that expresses a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered.
摘要翻译： 提供用于引发针对炭疽杆菌和其他杆菌的免疫应答的免疫原性组合物和方法，其包括炭疽杆菌的多聚-γ-谷氨酸（γPGA）多肽或表达γPGA多肽的另一种芽孢杆菌的免疫原性缀合物。 在施用共轭物的哺乳动物宿主中，γPGA偶联物引发针对炭疽杆菌或针对另一种芽孢杆菌的有效免疫应答。
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公开(公告)号：US20050158346A1
公开(公告)日：2005-07-21
申请号：US11035884
申请日：2005-01-18
CPC分类号： A61K39/07 , A61K2039/6081 , C07K16/1242 , C07K16/1271
摘要： The present invention relates, e.g., to a glycoconjugate composition comprising one or more polysaccharide types from a cell wall polysaccharide preparation from B. pumilus Sh 18, or variants thereof. Also disclosed are antibodies generated against the glycoconjugates, and methods of using the glycoconjugates and antibodies. An antimultiorganism vaccine which reacts against at least Haemophilus influenzae type a, Haemophilus influenzae type b, Staphylococcus aureus, and Staphylococcus epidermidis, is disclosed.
摘要翻译： 本发明涉及例如包含一种或多种多糖类型的糖缀合物组合物，所述多糖类型来自微生物短小芽孢杆菌Sh18的细胞壁多糖制剂或其变体。 还公开了针对糖缀合物产生的抗体，以及使用糖缀合物和抗体的方法。 公开了至少对流感嗜血杆菌a型，流感嗜血杆菌b型，金黄色葡萄球菌和表皮葡萄球菌进行反应的抗多元素疫苗。
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23.发明申请Cholesterol-containing compounds and their use as immunogens against borrelia burgdorferi 失效含胆固醇的化合物及其作为免疫球蛋白的用途公开(公告)号：US20060204515A1
公开(公告)日：2006-09-14
申请号：US10550907
申请日：2004-04-02
CPC分类号： A61K39/0225 , A61K47/6415 , A61K47/643 , A61K2039/6037 , C07J9/00 , C07J17/00 , Y02A50/401
摘要： Unique compounds that can be used for inducing an immune response to Borrelia burgdorferi in a subject by administering a therapeutically effective amount of the glycolipid to the subject. Such administration is particularly useful for preventing or treating Lyme disease in a subject. The compounds(s), and therapeutically acceptable salts thereof, may be formulated into pharmaceutical or immunogenic compositions.
摘要翻译： 独特的化合物可以通过向受试者施用治疗有效量的糖脂而在受试者中诱导针对博氏疏螺旋体的免疫应答。 这种给药对于预防或治疗受试者中的莱姆病特别有用。 化合物及其治疗上可接受的盐可以配制成药物或免疫原性组合物。
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公开(公告)号：US20050271675A1
公开(公告)日：2005-12-08
申请号：US11005851
申请日：2004-12-06
申请人： Rachel Schneerson , Joanna Kubler-Kielb , Fathy Majadly , Stephen Leppla , John Robbins , Darrell Liu , Joseph Shiloah
发明人： Rachel Schneerson , Joanna Kubler-Kielb , Fathy Majadly , Stephen Leppla , John Robbins , Darrell Liu , Joseph Shiloah
IPC分类号： A61K39/00 , A61K39/385 , C07K14/005 , C07K14/195 , C07K14/32
CPC分类号： C07K14/32 , A61K39/385 , A61K2039/6031 , A61K2039/6037 , A61K2039/627
摘要： Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazino-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.
摘要翻译： 制备免疫原性缀合物的方法，其包括与载体共价连接的半抗原或抗原。 所述方法包括使第一试剂与二酰肼反应，得到肼基改性的第一试剂，其中第一试剂是半抗原，抗原或载体; 使第二试剂与苯甲醛化合物反应，得到苯甲醛修饰的第二试剂，其中第二试剂是半抗原，抗原或载体，条件是第一试剂或第二试剂是载体; 并使肼修饰的第一试剂与苯甲醛修饰的第二试剂反应，得到包含通过腙键与载体共价连接的半抗原或抗原的免疫原性缀合物。
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25.发明授权Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine 失效使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法公开(公告)号：US07754227B2
公开(公告)日：2010-07-13
申请号：US11726304
申请日：2007-03-20
IPC分类号： A61K39/112
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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26.发明授权Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine 有权使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法公开(公告)号：US08202520B2
公开(公告)日：2012-06-19
申请号：US12790258
申请日：2010-05-28
IPC分类号： A61K39/385
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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27.发明授权Immunogenic polysaccharide-protein conjugates containing poly &agr;(2→8), &agr;(2→9) NeuNAc capsular polysaccharides 失效含有多聚α（2-> 8），α（2-> 9）NeuNAc荚膜多糖的免疫原性多糖 - 蛋白质缀合物公开(公告)号：US06632437B1
公开(公告)日：2003-10-14
申请号：US08153263
申请日：1993-11-15
IPC分类号： A61K39385
CPC分类号： C07K16/1203 , A61K38/00 , A61K39/095 , A61K47/646 , A61K2039/6037
摘要： The present invention relates to a polysaccharide-protein conjugate. The invention also relates to a method of using the conjugate to prevent systemic infections. The invention further relates to a pharmaceutical composition. The invention also relates to a method of producing a polysaccharide-protein conjugate.
摘要翻译： 本发明涉及多糖 - 蛋白质结合物。 本发明还涉及使用缀合物来预防全身感染的方法。 本发明还涉及药物组合物。 本发明还涉及一种生产多糖 - 蛋白质结合物的方法
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28.发明授权Methods of using Bacillus anthracis protective antigen sequences for vaccination 有权使用炭疽芽孢杆菌保护性抗原序列进行疫苗接种的方法公开(公告)号：US08703150B2
公开(公告)日：2014-04-22
申请号：US13244060
申请日：2011-09-23
CPC分类号： C07H21/04 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/32
摘要： The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
摘要翻译： 本发明涉及生产和回收炭疽芽孢杆菌保护性抗原（PA），特别是蛋白酶抗性的经修饰的PA的改进方法，以及使用这些PA或编码这些PA的核酸在人体中引发免疫原性应答的方法，包括 对炭疽杆菌细菌感染提供保护或降低其严重程度的反应，其可用于预防和/或治疗由炭疽芽孢杆菌引起的疾病，例如吸入性炭疽，皮肤炭疽和胃肠道炭疽。
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公开(公告)号：US20120009219A1
公开(公告)日：2012-01-12
申请号：US13244060
申请日：2011-09-23
CPC分类号： C07H21/04 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/32
摘要： The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
摘要翻译： 本发明涉及生产和回收炭疽芽孢杆菌保护性抗原（PA），特别是蛋白酶抗性的经修饰的PA的改进方法，以及使用这些PA或编码这些PA的核酸在人体中引发免疫原性应答的方法，包括 对炭疽杆菌细菌感染提供保护或降低其严重程度的反应，其可用于预防和/或治疗由炭疽芽孢杆菌引起的疾病，例如吸入性炭疽，皮肤炭疽和胃肠道炭疽。
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30.发明申请METHOD OF IMMUNIZING HUMANS AGAINST SALMONELLA TYPHI USING A VI-REPA CONJUGATE VACCINE 有权使用维生素C联合疫苗免疫沙门氏菌的人类免疫方法公开(公告)号：US20100239601A1
公开(公告)日：2010-09-23
申请号：US12790258
申请日：2010-05-28
IPC分类号： A61K39/385 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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