公开(公告)号：US06541223B2

公开(公告)日：2003-04-01

申请号：US09803609

申请日：2001-03-09

Applicant: H. Craig Dees ,  John Smolik

Inventor： H. Craig Dees ,  John Smolik

IPC: C12N506

CPC classification number: C07K14/47 ,  C12N7/00 ,  C12N2760/18451

Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.

公开(公告)号：US06495360B1

公开(公告)日：2002-12-17

申请号：US09543479

申请日：2000-04-06

Applicant: H. Craig Dees ,  John Smolik

Inventor： H. Craig Dees ,  John Smolik

IPC: C12N701

CPC classification number: C07K14/47 ,  C12N7/00 ,  C12N2760/18451

Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.