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公开(公告)号：US07844338B2
公开(公告)日：2010-11-30
申请号：US10881045
申请日：2004-06-30
IPC分类号： A61N1/18
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
摘要翻译： 用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。 将电信号施加到电极以调节迷走神经活性。 电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。 电信号的应用被停止。 重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。
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公开(公告)号：US07720540B2
公开(公告)日：2010-05-18
申请号：US11656132
申请日：2007-01-22
IPC分类号： A61N1/18
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. In another embodiment, the electrical signal is applied to the vagus nerve transmucosally. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is pancreatitis. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译： 通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。 在另一个实施例中，电信号通过经粘膜施用于迷走神经。 将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。 在一些实施方案中，该病症是胰腺炎。 该信号可以是阻塞或刺激信号。 在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。
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公开(公告)号：US07613515B2
公开(公告)日：2009-11-03
申请号：US11040767
申请日：2005-01-21
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode at a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency in excess of 3,000 Hz for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus.
摘要翻译： 用于治疗至少部分由迷走神经活动表征的多种病症中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官上。 将电信号施加到电极以调节迷走神经活性。 电信号以超过3000Hz的频率施加，以产生神经传导阻滞至迷走神经，神经传导阻滞被选择以至少部分阻断迷走神经冲动。
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公开(公告)号：US07444183B2
公开(公告)日：2008-10-28
申请号：US10752940
申请日：2004-01-06
IPC分类号： A61N1/06
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： A patient is treated with electrode positioned within a lumen of an esophagus of the patient and positioned at a mucosal layer of the esophagus. An electrical signal is applied to the electrode to to create a neural conduction block on a vagal trunk external to the esophagus.
摘要翻译： 用位于患者食管的内腔内的电极处理患者并且定位在食管的粘膜层。 将电信号施加到电极以在食道外部的迷走神经干线上产生神经传导阻滞。
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公开(公告)号：US08825164B2
公开(公告)日：2014-09-02
申请号：US13154846
申请日：2011-06-07
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译： 一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括至少一个被配置成植入患者体内并置于迷走神经的电极，所述电极还被配置为施加 在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的接通时间，所述电信号包括：a） 以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。
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公开(公告)号：US07077144B2
公开(公告)日：2006-07-18
申请号：US10825249
申请日：2004-04-14
CPC分类号： A61F5/56 , A61F2/0059
摘要： A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.
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公开(公告)号：US06971396B2
公开(公告)日：2005-12-06
申请号：US10629145
申请日：2003-07-29
CPC分类号： A61F5/56 , A61F2/0059
摘要： A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.
摘要翻译： 患者的上呼吸道状况如打鼾和睡眠呼吸暂停通过选择在组织内选择用于有限迁移的颗粒材料并促进组织对该材料的纤维化反应来治疗。 将大量颗粒材料注入组织区域以使组织结构变硬。
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公开(公告)号：US06742524B2
公开(公告)日：2004-06-01
申请号：US10394887
申请日：2003-03-21
IPC分类号： A61B1300
CPC分类号： A61F5/56 , A61F2/0059
摘要： A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.
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公开(公告)号：US20110307023A1
公开(公告)日：2011-12-15
申请号：US13154846
申请日：2011-06-07
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译： 一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括至少一个被配置成植入患者体内并置于迷走神经的电极，所述电极还被配置为施加 在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的接通时间，所述电信号包括：a） 以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。
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公开(公告)号：US07255110B2
公开(公告)日：2007-08-14
申请号：US11197271
申请日：2005-08-03
CPC分类号： A61F5/56 , A61F2/0059
摘要： A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic response of tissue to the material. A bolus of the particulate material is injected into the tissue area to structurally stiffen the tissue.
摘要翻译： 患者的上呼吸道状况如打鼾和睡眠呼吸暂停通过选择在组织内选择用于有限迁移的颗粒材料并促进组织对该材料的纤维化反应来治疗。 将大量颗粒材料注入组织区域以使组织结构变硬。
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