公开(公告)号：US20050175660A1

公开(公告)日：2005-08-11

申请号：US10977288

申请日：2004-10-29

申请人： Karl Mollison ,  Angela LeCaptain ,  Sandra Burke ,  Keith Cromack ,  Peter Tarcha

发明人： Karl Mollison ,  Angela LeCaptain ,  Sandra Burke ,  Keith Cromack ,  Peter Tarcha

IPC分类号： A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  C07D498/18 ,  A61K31/4745 ,  A61F2/00

CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

摘要翻译： 一种医疗装置，包括能够容纳或支持药学上可接受的载体或赋形剂的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层， 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于：该药物可与另一药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂 ，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。