公开(公告)号：US20110168882A1

公开(公告)日：2011-07-14

申请号：US12528454

申请日：2008-02-26

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J49/26

CPC分类号： H01J49/062 ,  H01J49/408 ,  H01J49/42

摘要： A mass spectrometer is disclosed comprising an ion guide (1) or ion mobility spectrometer having helical, toroidal, part-toroidal, hemitoroidal, semitoroidal or spiral ion guiding region (4). The ion guide (1) may comprise a tube made from a leaky dielectric wherein an RF voltage is applied to outer electrodes in order to confine ions radially within the ion guide (1). A DC voltage is applied to a resistive inner layer in order to urge ions along the ion guide (1). Alternatively, the ion guide may comprise a plurality of electrodes each having an aperture through which ions are transmitted.

摘要翻译： 公开了一种质谱仪，其包括具有螺旋，环形，部分环形，椭圆形，半形或螺旋离子导向区域（4）的离子导向器（1）或离子迁移谱仪。 离子导向器（1）可以包括由泄漏电介质制成的管，其中将RF电压施加到外部电极以将离子径向限制在离子导向器（1）内。 DC电压被施加到电阻内层，以促使沿离子导向器（1）的离子。 或者，离子导向器可以包括多个电极，每个电极都具有一个孔，通过该孔可传输离子。

公开(公告)号：US06906319B2

公开(公告)日：2005-06-14

申请号：US10274949

申请日：2002-10-22

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J49/16 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/004 ,  H01J49/401 ,  H01J49/42 ,  H01J49/429

摘要： A mass spectrometer is disclosed wherein ions having a particular desired charge state are selected by operating an ion mobility spectrometer in combination with a quadrupole mass filter. Precursor ions are fragmented or reacted to form product ions in a collision cell ion trap and sent back upstream to an upstream ion trap. The fragment or product ions are then passed through the ion mobility spectrometer wherein they become temporally separated according to their ion mobility. Fragment or product ions are then re-trapped in the collision cell ion trap before being released therefrom in packets. A pusher electrode of a time of flight mass analyzer is energized a predetermined period of time after a packet of ions is released from the collision cell ion trap. Accordingly, it is possible to select multiply charged precursor ions from a background of singly charged ions, fragment them, and mass analyze the fragment ions with a near 100% duty cycle across the whole mass range.

摘要翻译： 公开了一种质谱仪，其中通过与四极质量过滤器结合操作离子迁移谱仪来选择具有特定所需电荷状态的离子。 前体离子被碎裂或反应以在碰撞细胞离子阱中形成产物离子，并在上游返回到上游离子阱。 然后将片段或产物离子通过离子迁移谱仪，其中它们根据其离子迁移率暂时分离。 然后将碎片或产物离子重新捕获在碰撞细胞离子阱中，然后从包中释放。 飞行时间质量分析器的推动器电极在从碰撞池离子阱中释放离子束之后经过预定的时间段通电。 因此，可以从单电荷离子的背景中选择多电荷的前体离子，使其分裂，并且在整个质量范围内以近100％的占空比质量分析碎片离子。

公开(公告)号：US08283628B2

公开(公告)日：2012-10-09

申请号：US13060100

申请日：2009-08-14

申请人： John Brian Hoyes ,  David J. Langridge

发明人： John Brian Hoyes ,  David J. Langridge

IPC分类号： B01D59/44

CPC分类号： H01J49/0081 ,  G01N27/622

摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).

摘要翻译： 公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。 具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪 防止离子向上传播。 由离子栅（6）传输的离子被捕获在下游离子阱（7）中。 然后离子返回上游到第二上游离子阱（4）。

公开(公告)号：US20110291001A1

公开(公告)日：2011-12-01

申请号：US13060100

申请日：2009-08-14

申请人： John Brian Hoyes ,  David J. Langridge

发明人： John Brian Hoyes ,  David J. Langridge

IPC分类号： H01J49/26

CPC分类号： H01J49/0081 ,  G01N27/622

摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).

摘要翻译： 公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。 具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪 防止离子向上传播。 由离子栅（6）传输的离子被捕获在下游离子阱（7）中。 然后离子返回上游到第二上游离子阱（4）。

公开(公告)号：US07960694B2

公开(公告)日：2011-06-14

申请号：US12373204

申请日：2007-07-09

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： H01J49/36 ,  H01J49/0031 ,  H01J49/4235

摘要： A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass ((analyser 2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC′ or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser (2).

摘要翻译： 提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。 沿着质量轴（（分析仪2））产生多个伪电位波纹，伪电位波纹的振幅或深度与离子的质荷比成反比，一个或多个瞬态直流电压 被施加到质量分析器（2）的电极，以沿着质量分析器（2）的长度推动离子，施加到电极的瞬态DC电压的幅度随时间增加并且离子被发射 从质量分析器（2）以其质量与电荷比的相反顺序将两个AC或RF电压施加到电极上，第一AC或RF电压被布置成提供最佳伪电位波纹，而第二AC'或RF 电压被布置成在质量分析器（2）内提供离子的最佳径向约束。

公开(公告)号：US06717130B2

公开(公告)日：2004-04-06

申请号：US09876122

申请日：2001-06-08

申请人： Robert Harold Bateman ,  John Brian Hoyes ,  Edward James Clayton

发明人： Robert Harold Bateman ,  John Brian Hoyes ,  Edward James Clayton

IPC分类号： B01D5944

CPC分类号： H01J49/0045

摘要： A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source are incident upon a collision cell which alternately and repeatedly switches between a first mode wherein the ions are substantially fragmented to produce daughter ions and a second mode wherein the ions are not substantially fragmented. Mass spectra are taken in both modes, and at the end of an experimental run parent and daughter ions are recognized by comparing the mass spectra obtained in the two different modes. Daughter ions are matched to particular parent ions on the basis of the closeness of fit of their elution times, and this enables parent ions to then be identified.

摘要翻译： 公开了一种通过匹配发现在母体离子从混合物中洗脱出的基本上同时产生的子离子来鉴定亲本离子的方法。 从离子源发射的离子入射到碰撞单元上，该碰撞单元在离子基本上分裂以产生子离子的第一模式之间交替重复地切换，而第二模式其中离子基本上不分段。 在两种模式下都采用质谱，在实验运行结束时，通过比较两种不同模式中获得的质谱来识别母体和子离子。 基于其洗脱时间的拟合程度，子离子与特定的母体离子相匹配，这使母体离子能够被识别。

公开(公告)号：US20110284734A1

公开(公告)日：2011-11-24

申请号：US12864275

申请日：2009-01-26

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J49/34

CPC分类号： H01J49/004 ,  G01N27/622

摘要： An ion mobility spectrometer (2) is disclosed wherein the potential difference between the exit region of an ion trap (1) arranged upstream of the ion mobility spectrometer (2) and the entrance region to the ion mobility spectrometer (2) is varied temporally with time in order to optimise the transmission of ions from the ion trap (1) into the ion mobility spectrometer (2) so as to avoid fragmentation of the ions.

摘要翻译： 公开了一种离子迁移谱仪（2），其中布置在离子迁移谱仪（2）上游的离子阱（1）的出口区域与离子迁移谱仪（2）的入口区域之间的电位差随着时间上改变而与 时间以优化离子从离子阱（1）到离子迁移谱仪（2）的透射，以避免离子的破碎。

公开(公告)号：US08415618B2

公开(公告)日：2013-04-09

申请号：US12864275

申请日：2009-01-26

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： B01D59/44

CPC分类号： H01J49/004 ,  G01N27/622

摘要： An ion mobility spectrometer is disclosed wherein the potential difference between the exit region of an ion trap arranged upstream of the ion mobility spectrometer and the entrance region to the ion mobility spectrometer is varied temporally with time in order to optimise the transmission of ions from the ion trap into the ion mobility spectrometer so as to avoid fragmentation of the ions.

摘要翻译： 公开了一种离子迁移谱仪，其中布置在离子迁移谱仪上游的离子阱的出口区域与离子迁移谱仪的入口区域之间的电势差随时间而变化，以优化来自离子的离子的透射 陷入离子迁移谱仪，以避免离子的碎裂。

公开(公告)号：US20110233396A1

公开(公告)日：2011-09-29

申请号：US13157021

申请日：2011-06-09

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J49/26

CPC分类号： H01J49/36 ,  H01J49/0031 ,  H01J49/4235

摘要： A mass analyser 2 is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser 2. The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser 2 in order to urge ions along the length of the mass analyser 2. The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser 2 in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser 2.

摘要翻译： 提供质量分析器2，其包括具有孔的多个电极，在使用中通过该孔具有离子的透过。 沿着质量分析器2的轴线产生多个伪电位波纹。伪电位波纹的振幅或深度与离子的质荷比成反比。 一个或多个瞬态直流电压被施加到质量分析器2的电极，以沿着质量分析器2的长度推动离子。施加到电极的瞬态DC电压的幅度随时间增加而增加离子 从质量分析器2以其质荷比的相反顺序发射。 两个AC或RF电压施加到电极。 第一AC或RF电压被布置成提供最佳伪电位波纹，而第二AC或RF电压被布置成在质量分析器2内提供离子的最佳径向约束。

公开(公告)号：US08552366B2

公开(公告)日：2013-10-08

申请号：US12528454

申请日：2008-02-26

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J49/06 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/062 ,  H01J49/408 ,  H01J49/42

摘要： A mass spectrometer is disclosed comprising an ion guide or ion mobility spectrometer having helical, toroidal, part-toroidal, hemitoroidal, semitoroidal or spiral ion guiding region. The ion guide may comprise a tube made from a leaky dielectric wherein an RF voltage is applied to outer electrodes in order to confine ions radially within the ion guide. A DC voltage is applied to a resistive inner layer in order to urge ions along the ion guide. Alternatively, the ion guide may comprise a plurality of electrodes each having an aperture through which ions are transmitted.

摘要翻译： 公开了一种质谱仪，其包括具有螺旋，环形，部分环形，椭圆形，半形或螺旋离子引导区的离子导向或离子迁移谱仪。 离子导向器可以包括由泄漏电介质制成的管，其中RF电压被施加到外部电极以便将离子径向限制在离子引导件内。 DC电压被施加到电阻内层，以沿着离子导向器迫使离子。 或者，离子导向器可以包括多个电极，每个电极都具有一个孔，通过该孔可传输离子。