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公开(公告)号:US6001653A
公开(公告)日:1999-12-14
申请号:US203716
申请日:1998-12-02
申请人: Stanley T. Crooke , Walter F. Lima , Hongjiang Wu
发明人: Stanley T. Crooke , Walter F. Lima , Hongjiang Wu
IPC分类号: C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , C07K16/40 , C12N9/22 , C12Q1/02 , C12Q1/68 , C07H21/00 , C07H21/04 , C12N15/52
CPC分类号: C12N9/22 , C12N15/113 , A61K38/00 , C12N2310/11
摘要: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
摘要翻译: 本发明提供了由其编码的人2型核糖核酸酶H的多核苷酸和多肽。还提供了在增强反义寡核苷酸疗法中使用这些多核苷酸和多肽的方法。