公开(公告)号：US20180171306A1

公开(公告)日：2018-06-21

申请号：US15865713

申请日：2018-01-09

Applicant: Life Technologies Corporation ,  The Johns Hopkins University

Inventor： Brian Agnew ,  David Graham

IPC: C12N7/00 ,  A61K39/00 ,  A61K48/00

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

公开(公告)号：US20150037288A1

公开(公告)日：2015-02-05

申请号：US14374404

申请日：2013-01-25

Applicant: LIFE TECHNOLOGIES CORPORATION ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Brian Agnew ,  David Graham

IPC: C12N7/00

CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K48/00 ,  C12N2740/16034 ,  C12N2740/16045 ,  C12N2740/16051 ,  C12N2810/10

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.