公开(公告)号：US20150037288A1

公开(公告)日：2015-02-05

申请号：US14374404

申请日：2013-01-25

申请人： LIFE TECHNOLOGIES CORPORATION ,  THE JOHNS HOPKINS UNIVERSITY

发明人： Brian Agnew ,  David Graham

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K48/00 ,  C12N2740/16034 ,  C12N2740/16045 ,  C12N2740/16051 ,  C12N2810/10

摘要： Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.