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30 条记录 (耗时 0.037 秒)

    Use of anhydrovinblastine
    21.
    发明授权
    Use of anhydrovinblastine 失效
    使用脱氢长春花碱

    公开(公告)号：US6011041A

    公开(公告)日：2000-01-04

    申请号：US690195

    申请日：1996-07-26

    申请人： Bruce Schmidt ,  James Kutney ,  Lawrence Mayer

    发明人： Bruce Schmidt ,  James Kutney ,  Lawrence Mayer

    IPC分类号： C07D519/04 ,  A61K31/33 ,  A61K31/485 ,  A61K43/42

    CPC分类号： C07D519/04 ,  Y10S514/908

    摘要： The present invention is particularly directed to the use of a derivative of vinblastine, 3',4'-anhydrovinblastine (AHVB), which differs from vinblastine in that it possesses a double bond at the 3',4' position of the caranthine nucleus rather than the hydroxyl group that is present in the parent structure, as an antineoplastic agent in the therapeutic treatment of cancer. Specifically, the treatment of lymphoma with 3',4'-anhydrovinblastine is disclosed.

    摘要翻译： 本发明特别涉及长春碱，3'，4'-脱氢长春碱（AHVB）的衍生物，其与长春花碱不同，因为它在黄嘌呤核的3'，4'位具有双键，而不是 比在母体结构中存在的羟基作为癌症治疗性治疗中的抗肿瘤剂。 具体地，公开了用3'，4'-脱氢长春花碱治疗淋巴瘤。

    Liposomal formulations of anthracycline agents and cytidine analogs
    23.
    发明授权
    Liposomal formulations of anthracycline agents and cytidine analogs 有权
    蒽环类药物和胞苷类似物的脂质体制剂

    公开(公告)号：US08431806B2

    公开(公告)日：2013-04-30

    申请号：US13237807

    申请日：2011-09-20

    申请人： Lawrence Mayer ,  Sharon Johnstone ,  Troy Harasym

    发明人： Lawrence Mayer ,  Sharon Johnstone ,  Troy Harasym

    IPC分类号： A61K9/127

    CPC分类号： A61K9/127 ,  A61K9/1278 ,  A61K31/704 ,  A61K31/706 ,  A61K31/7068 ,  Y10S977/801 ,  A61K2300/00

    摘要： Compositions which comprise an anthracycline agent, and a cytidine analog are encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin, doxorubicin, and idarubicin, while the preferred cytidine analog is selected from the group of cytarabine, gemcitabine, or 5-azacytidine. The combination of the anthracycline agent and cytidine analog encapsulated in said liposomal carriers are useful in achieving a drug retention and a sustained drug release for each therapeutic agent.

    摘要翻译： 包含蒽环类药物和胞苷类似物的组合物被包封在脂质体载体中。 优选的蒽环类药物选自柔红霉素，多柔比星和伊达比星组，而优选的胞苷类似物选自阿糖胞苷，吉西他滨或5-氮杂胞苷组。 包封在所述脂质体载体中的蒽环类药物和胞苷类似物的组合可用于实现每种治疗剂的药物保留和持续的药物释放。

    Portfolio and method of making the same
    30.
    发明授权
    Portfolio and method of making the same 失效
    组合和制作方法

    公开(公告)号：US5975578A

    公开(公告)日：1999-11-02

    申请号：US98053

    申请日：1998-06-16

    申请人： Lawrence Mayer

    发明人： Lawrence Mayer

    IPC分类号： B42D3/02 ,  B42F7/02 ,  B42D3/00

    CPC分类号： B42D3/02 ,  B42F7/02 ,  Y10S412/902

    摘要： A portfolio includes a rectangular piece of a canvas material having an outer peripheral edge, a rectangular peripheral piece of a vinyl material having an inner peripheral edge that slightly overlaps the outer peripheral edge of the canvas material, with an inner surface of the inner peripheral edge and an outer surface of the outer peripheral edge being heat sealed to each other with a predetermined stitching pattern, a first cardboard rigidifying member positioned to an inner surface of the canvas material corresponding to a top panel of the desk folder, a second cardboard rigidifying member positioned to an inner surface of the canvas material adjacent to the first rigidifying member, corresponding to a bottom panel of the desk folder, with a spacing between the first and second rigidifying members which defines a narrow binding edge which connects together side edges of the top and bottom panels, a vinyl backing member positioned over the first and second rigidifying members being heat sealed to the vinyl material so as to retain the rigidifying members between the backing member and the canvas material, and decorative stitching applied to an outer periphery of the portfolio.

    摘要翻译： 投资组合包括具有外围边缘的长方形帆布材料片，具有与帆布材料的外周边缘稍微重叠的内周边缘的乙烯基材料的矩形周边片，内周边缘的内表面 并且外周边缘的外表面以预定的缝合图案彼此热密封;第一纸板硬化构件，其定位在与桌面文件夹的顶板对应的帆布材料的内表面上;第二纸板硬化构件 定位在与第一刚性构件相邻的帆布材料的内表面上，对应于桌面文件夹的底板，第一和第二固定构件之间的间隔限定了窄的装订边缘，其将顶部的侧边缘连接在一起 和底板，位于所述第一和第二刚性构件上方的乙烯基背衬构件 热密封到乙烯基材料上，以将刚性构件保持在背衬构件和帆布材料之间，以及装饰缝合施加到组合的外围。