公开(公告)号：US20100028779A1

公开(公告)日：2010-02-04

申请号：US12533664

申请日：2009-07-31

Applicant: Qing GONG ,  Weiguo Yang ,  Lin Jiang ,  Jingyu Ren

Inventor： Qing GONG ,  Weiguo Yang ,  Lin Jiang ,  Jingyu Ren

IPC: H01M4/58 ,  C08J9/16 ,  C08G73/10

CPC classification number: H01M2/1653 ,  B01D67/0027 ,  B01D67/0093 ,  B01D71/64 ,  B01D2325/02 ,  C08G73/1046 ,  C08G73/105 ,  C08G73/1067 ,  C08G73/1071 ,  C08J9/26 ,  C08J2201/044 ,  C08J2379/08 ,  C08L79/08

Abstract: A porous polyimide membrane is provided. The volume of pores with a diameter of between about 50 and about 300 nm is more than about 40%, preferably more than 75% of the total pore volume in the membrane. A method for preparing a porous polyimide membrane comprises: preparing a porous polyamide acid membrane; stretching the porous polyamide acid membrane to form a stretched membrane; and imidizing the stretched membrane to form a porous polyimide membrane. The volume of the pores with a diameter of about 50-300 nm is more than about 40%, preferably more than 75% of the total pore volume in the porous polyimide membrane.

Abstract translation: 提供多孔聚酰亚胺膜。 直径为约50至约300nm的孔的体积大于膜中总孔体积的约40％，优选大于75％。 制备多孔聚酰亚胺膜的方法包括：制备多孔聚酰胺酸膜; 拉伸多孔聚酰胺酸膜以形成拉伸膜; 并且将拉伸的膜酰亚胺化以形成多孔聚酰亚胺膜。 直径约50-300nm的孔的体积大于多孔聚酰亚胺膜中总孔体积的约40％，优选大于75％。

公开(公告)号：US20090191607A1

公开(公告)日：2009-07-30

申请号：US12334360

申请日：2008-12-12

Applicant: David Baker ,  Alexandre Zanghellini ,  Lin Jiang ,  Andrew Wollacott ,  Daniela Grabs-Rothlisberger ,  Eric Althoff

Inventor： David Baker ,  Alexandre Zanghellini ,  Lin Jiang ,  Andrew Wollacott ,  Daniela Grabs-Rothlisberger ,  Eric Althoff

IPC: C12N9/14

CPC classification number: C12N9/88 ,  G06F19/24

Abstract: Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases.

Abstract translation: 本文公开了用于计算设计酶的技术。 这些技术可用于设计天然存在的酶的变体，以及不具有天然对应物的新酶。 这些技术基于首先鉴定促进所需反应所需的功能性反应位点。 然后，使用散列算法来鉴定能够支持所需功能位点的潜在的蛋白质主链结构（即支架）。 这些技术用于设计出显示醛醇反应催化功能的32种不同的蛋白质序列，其中31种在序列表中定义。 提供了这31种不同合成醛缩酶的细节，包括如何将这些合成醛缩酶与天然存在的醛缩酶相区分。