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21.发明申请公开(公告)号：US20070092875A1
公开(公告)日：2007-04-26
申请号：US10532432
申请日：2003-10-22
申请人： Gregory Plowman
发明人： Gregory Plowman
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/485 , G01N33/574 , G01N2333/9121 , G01N2500/04 , G01N2800/32
摘要： Human MAP2K6 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAP2K6 are provided.
摘要翻译： 人MAP2K6基因被鉴定为分支形态发生的调节剂，因此是与缺陷支链形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法，包括筛选调节MAP2K6活性的试剂。
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公开(公告)号：US20060234344A1
公开(公告)日：2006-10-19
申请号：US11377316
申请日：2006-03-17
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to novel kinase polypetides, nucleotide sequences encoding the novel kinase polypetides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related disease and conditions.
摘要翻译： 本发明涉及新型激酶多肽，编码新型激酶多肽的核苷酸序列，以及可用于诊断和治疗各种激酶相关疾病和病症的各种产物和方法。
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公开(公告)号：US06716575B2
公开(公告)日：2004-04-06
申请号：US09012135
申请日：1998-01-22
申请人： Gregory Plowman , Kevin Mossie
发明人： Gregory Plowman , Kevin Mossie
IPC分类号： C12Q168
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C12Q1/485 , G01N2333/9121 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR1 and/or AUR2 related diseases or conditions characterized by an abnormal interaction between a AUR1 and/or AUR2 polypeptide and a AUR1 and/or AUR2 binding partner.
摘要翻译： 本发明涉及AUR1和/或AUR2多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，此类多肽的抗体，利用此类多肽的测定法以及与上述所有相关的方法。 AUR1和/或AUR2相关疾病或特征为AUR1和/或AUR2多肽与AUR1和/或AUR2结合配偶体之间异常相互作用的病症的治疗，诊断和筛选方法。
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24.发明授权Polynucleotides encoding STE20-related protein kinases and methods of use 失效编码STE20相关蛋白激酶的多核苷酸及其使用方法公开(公告)号：US06680170B2
公开(公告)日：2004-01-20
申请号：US09291417
申请日：1999-04-13
申请人： Gregory Plowman , Ricardo Martinez , David Whyte
发明人： Gregory Plowman , Ricardo Martinez , David Whyte
IPC分类号： C12Q168
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to the nucleic acid molecules encoding an STE20-related family of novel protein kinases, ZC1, ZC2, ZC3, ZC4, STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, KHS2, SULU1, SULU3, GEK2, PAK4 and PAK5, segments and domains thereof, as well as various methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Mammalian nucleic acid molecules encoding these kinases are particularly disclosed, and more specifically human sources of these nucleic acids are disclosed.
摘要翻译： 本发明涉及编码STE20相关家族新型蛋白激酶ZC1，ZC2，ZC3，ZC4，STLK2，STLK3，STLK4，STLK5，STLK6，STLK7，KHS2，SULU1，SULU3，GEK2，PAK4的核酸分子和 PAK5，其片段和结构域，以及可用于诊断和治疗各种激酶相关疾病和病症的各种方法。 特别公开了编码这些激酶的哺乳动物核酸分子，更具体地公开了这些核酸的人源。
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公开(公告)号：US06656716B1
公开(公告)日：2003-12-02
申请号：US09688188
申请日：2000-10-16
申请人： Gregory Plowman , Ricardo Martinez , David Whyte
发明人： Gregory Plowman , Ricardo Martinez , David Whyte
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention related to the novel human kinase polypeptides STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, ZC1, ZC2, ZC3, ZC4, KHS2, SULU1, SULU2, SULU3, GEK2, PAK4, and PAK5, nucleotide sequences encoding the novel kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions.
摘要翻译： 本发明涉及新型人激酶多肽STLK2，STLK3，STLK4，STLK5，STLK6，STLK7，ZC1，ZC2，ZC3，ZC4，KHS2，SULU1，SULU2，SULU3，GEK2，PAK4和PAK5， 激酶多肽，以及可用于诊断和治疗各种激酶相关疾病和病症的各种产物和方法。
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26.发明申请公开(公告)号：US20070072261A1
公开(公告)日：2007-03-29
申请号：US10725330
申请日：2003-12-02
申请人： Gregory Plowman , Ricardo Martinez , David Whyte
发明人： Gregory Plowman , Ricardo Martinez , David Whyte
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to the nucleic acid molecules encoding an STE20-related family of novel protein kinases, ZC1, ZC2, ZC3, ZC4, STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, KHS2, SULU1, SULU3, GEK2, PAK4 and PAK5, segments and domains thereof, as well as various methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Mammalian nucleic acid molecules encoding these kinases are particularly disclosed, and more specifically human sources of these nucleic acids are disclosed.
摘要翻译： 本发明涉及编码STE20相关家族新型蛋白激酶ZC1，ZC2，ZC3，ZC4，STLK2，STLK3，STLK4，STLK5，STLK6，STLK7，KHS2，SULU1，SULU3，GEK2，PAK4的核酸分子和 PAK5，其片段和结构域，以及可用于诊断和治疗各种激酶相关疾病和病症的各种方法。 特别公开了编码这些激酶的哺乳动物核酸分子，更具体地公开了这些核酸的人源。
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公开(公告)号：US20060216730A1
公开(公告)日：2006-09-28
申请号：US11320072
申请日：2005-12-29
申请人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez , Peter Flanagan , Douglas Clary
发明人： Gregory Plowman , David Whyte , Gerard Manning , Sucha Sudarsanam , Ricardo Martinez , Peter Flanagan , Douglas Clary
CPC分类号： G01N33/6896 , C12Q1/485 , G01N33/57407 , G01N33/6893
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted.
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公开(公告)号：US20060140954A1
公开(公告)日：2006-06-29
申请号：US11299791
申请日：2005-12-13
CPC分类号： C07K16/40 , C12N9/1205 , C12Q1/485 , G01N2500/00
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the PTK's and STK's have been identified and their protein structure predicted.
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公开(公告)号：US20050142625A1
公开(公告)日：2005-06-30
申请号：US10725121
申请日：2003-12-02
申请人： Gregory Plowman , Ricardo Martinez , David Whyte
发明人： Gregory Plowman , Ricardo Martinez , David Whyte
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P9/00 , A61P9/10 , A61P13/12 , A61P25/00 , A61P35/00 , A61P37/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/52 , C12Q1/68 , G01N33/53 , C12N5/06 , G01N33/537 , G01N33/543
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to the nucleic acid molecules encoding an STE20-related family of novel protein kinases, ZC1, ZC2, ZC3, ZC4, STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, KHS2, SULU1, SULU3, GEK2, PAK4 and PAK5, segments and domains thereof, as well as various methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Mammalian nucleic acid molecules encoding these kinases are particularly disclosed, and more specifically human sources of these nucleic acids are disclosed.
摘要翻译： 本发明涉及编码STE20相关家族新型蛋白激酶ZC1，ZC2，ZC3，ZC4，STLK2，STLK3，STLK4，STLK5，STLK6，STLK7，KHS2，SULU1，SULU3，GEK2，PAK4的核酸分子和 PAK5，其片段和结构域，以及可用于诊断和治疗各种激酶相关疾病和病症的各种方法。 特别公开了编码这些激酶的哺乳动物核酸分子，更具体地公开了这些核酸的人源。
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公开(公告)号：US20050054070A1
公开(公告)日：2005-03-10
申请号：US10716442
申请日：2003-11-20
申请人： Gregory Plowman , David Whyte , Gerard Manning
发明人： Gregory Plowman , David Whyte , Gerard Manning
摘要： The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase phosphatase PTP's and STP's have been identified and their protein structure predicted.
摘要翻译： 本发明涉及磷酸酶多肽，编码磷酸酶多肽的核苷酸序列，以及可用于诊断和治疗各种磷酸酶相关疾病和病症的各种产品和方法。 通过使用生物信息学策略，已经鉴定了MAP激酶磷酸酶PTP和STP的哺乳动物成员，并预测了其蛋白质结构。
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