公开(公告)号：US09555007B2

公开(公告)日：2017-01-31

申请号：US13831250

申请日：2013-03-14

Applicant: The Children's Medical Center Corporation ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Minglin Ma ,  Daniel G. Anderson ,  Robert S. Langer ,  Omid Veiseh ,  Arturo Jose Vegas ,  Joshua Charles Doloff ,  Delai Chen ,  Christian J. Kastrup

IPC: A61K9/00 ,  A61K9/50 ,  A61K35/39 ,  A61K35/12

CPC classification number: A61K35/39 ,  A61K9/0024 ,  A61K9/5036 ,  A61K9/5078 ,  A61K9/5089 ,  A61K2035/126 ,  A61K2035/128 ,  B01J13/046

Abstract: Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

Abstract translation: 公开了包封直径大于1mm的哺乳动物细胞和任选的无细胞核的生物相容性水凝胶胶囊，其在植入受试者后具有减少的纤维化过度生长。 还公开了治疗受试者疾病的方法，其涉及向受试者施用治疗有效量的所公开的封闭细胞。