Indolyl-substituted pyrazino-quinolines and their use for the treatment of cancer
    21.
    发明授权
    Indolyl-substituted pyrazino-quinolines and their use for the treatment of cancer 有权
    吲哚基取代的吡嗪 - 喹啉及其用于治疗癌症的用途

    公开(公告)号:US08754086B2

    公开(公告)日:2014-06-17

    申请号:US13379497

    申请日:2010-03-19

    CPC classification number: A61K31/4985 C07D471/04 C07D471/14 C07D491/14

    Abstract: The disclosure describes compounds of formula I, wherein the wedged bonds, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof; and methods of using such compounds useful in the treatment of cancer and conditions affected by inhibition of angiogenesis. Also provided, are processes for the preparation of formula I, by reacting formula I with other compounds; and processes for the preparation of a pharmaceutical formulation by bringing into association, a compound of formula I, with therapeutic agents and/or a pharmaceutically-acceptable adjuvant, diluent, or carrier.

    Abstract translation: 本发明描述了式I化合物,其中楔形键,R1,R2,R3,R4,R5,R5a,R6,R7,R8,R9,R10,R11,R12,R13,R14,X和Y具有 描述及其药学上可接受的盐; 以及使用这些化合物可用于治疗癌症和受血管生成抑制影响的病症的方法。 还提供了通过使式I与其它化合物反应制备式I的方法; 以及通过将式I化合物与治疗剂和/或药学上可接受的佐剂,稀释剂或载体结合而制备药物制剂的方法。

    PERCUTANEOUS IMPLANT AND OSTOMY METHOD
    22.
    发明申请
    PERCUTANEOUS IMPLANT AND OSTOMY METHOD 有权
    PERCUTANEOUS IMPLANT和OSTOMY方法

    公开(公告)号:US20140052085A1

    公开(公告)日:2014-02-20

    申请号:US14006647

    申请日:2012-03-26

    CPC classification number: A61F5/445 A61F2005/4455

    Abstract: A percutaneous ostomy implant for implantation into the abdominal wall of a patient is provided, which includes a connecting member for mounting an external detachable device thereto; a first tubular ingrowth member depending from the connecting member; and a second tubular ingrowth member depending from the connecting member and being radially outwardly spaced from the first tubular ingrowth member. The first tubular ingrowth member is configured and dimensioned to receive a bowel segment within it to allow the stoma and serosal tissue of that bowel segment to infiltrate the first tubular ingrowth member. The second tubular member is configured and dimensioned to abut dermal tissue to allow the dermal tissue to infiltrate the second tubular ingrowth member, thereby securing and sealing the ostomy implant to the dermis.

    Abstract translation: 提供一种用于植入患者腹壁的经皮造口植入物,其包括用于将外部可拆卸装置安装到其上的连接构件; 第一管状向内生长构件,其从所述连接构件悬垂; 以及第二管状向内生长构件,其从连接构件悬垂并且与第一管状向内生长构件径向向外间隔开。 第一管状向内生长构件的构造和尺寸被设计成在其内容纳肠段以允许该肠段的造口和浆膜组织渗透第一管状向内生长构件。 第二管状构件的构造和尺寸被设计成邻接真皮组织以允许真皮组织渗透第二管状向内生长构件,从而将造口植入物固定并密封到真皮层。

    Implant and method for its manufacture
    23.
    发明授权
    Implant and method for its manufacture 有权
    种植体及其制造方法

    公开(公告)号:US08647304B2

    公开(公告)日:2014-02-11

    申请号:US12280610

    申请日:2007-02-28

    CPC classification number: A61F5/445 A61F2005/4455 A61M39/0247 A61M2039/0261

    Abstract: An implant for percutaneous implantation through the abdominal wall for encircling and engaging an externalized length of a body duct of a human or animal patient. The implant has an exterior ring section protruding outwardly from the abdominal wall with a free end which serves for mounting of a detachable device, and an interior section extending through the abdominal wall and inside the patient for internal fixation of the implant. The exterior ring section and interior section have a common axis. The internal circumference of at least a part of the exterior ring section above the interior section is arranged with a biocompatible, integrated ingrowth means for the exterior surface of the body duct wall.

    Abstract translation: 用于通过腹壁进行经皮植入的植入物,用于环绕和接合人或动物患者的身体导管的外部长度。 植入物具有从腹壁向外突出的外环部分,其具有用于安装可拆卸装置的自由端,以及延伸穿过腹壁和患者内部的内部部分,用于植入物的内部固定。 外环部分和内部部分具有共同的轴线。 在内部部分上方的外环部分的至少一部分的内圆周布置有用于体管道壁的外表面的生物相容的,整合的向内生长装置。

    Antenna switching arrangement
    24.
    发明授权
    Antenna switching arrangement 有权
    天线切换装置

    公开(公告)号:US08457697B2

    公开(公告)日:2013-06-04

    申请号:US12742898

    申请日:2007-11-14

    CPC classification number: H01Q3/24

    Abstract: An antenna arrangement comprising an input/output connection and a first and a second tuning network with different transfer functions. The arrangement additionally comprises an antenna and a switch for connecting the input/output connection of the arrangement to one of said tuning networks, with a second switch for connecting the antenna of the arrangement to the tuning network to which the input/output connection of the arrangement has been connected. The arrangement comprises a sensor for sensing a form factor of the arrangement or of an apparatus in which the arrangement is used, and said sensor can be used for influencing said first and second switches, so that a device which has been connected to the arrangement may be connected to the antenna via a tuning network optimal for the current form factor of the arrangement.

    Abstract translation: 一种包括输入/​​输出连接和具有不同传送功能的第一和第二调谐网络的天线装置。 该装置还包括天线和用于将该装置的输入/输出连接连接到所述调谐网络中的一个的开关,用于将该装置的天线连接到调谐网络的第二开关,该调谐网络的输入/输出连接 安排已经连接。 该装置包括用于感测布置的形状因子的传感器或使用该装置的装置,并且所述传感器可用于影响所述第一和第二开关,使得已经连接到该装置的装置可以 通过调谐网络连接到天线,该调谐网络最适合当前的布置形式。

    Method and apparatus for generating coverage in a cellular network
    25.
    发明授权
    Method and apparatus for generating coverage in a cellular network 有权
    用于在蜂窝网络中生成覆盖的方法和装置

    公开(公告)号:US08385926B2

    公开(公告)日:2013-02-26

    申请号:US12517323

    申请日:2006-12-11

    CPC classification number: H04W16/26 H04B7/15507 H04B7/2606 H04W24/02

    Abstract: A sub-node, such as a repeater station or relay station, equipped with a multi-beam sub-node link antenna. The beams of the sub-node link antenna allow communication between the sub-node and at least two nodes (access points/base stations) 11A-B; 11A-E. The sub-node is further provided with at least one transmitting and receiving coverage antenna to generate coverage in at least one geographical secondary coverage area a; a-c, and a control mechanism that selects one of the nodes to extend the geographical primary coverage area A-B; A-E of the node 11A-B; 11A-E to include the geographical secondary coverage area a; a-c of the sub-node. The invention is also related to a cellular communication network, and a method for generating coverage in a cellular communication network.

    Abstract translation: 具有多光束子节点链路天线的子节点,诸如中继站或中继站。 子节点链路天线的波束允许子节点与至少两个节点(接入点/基站)11A-B之间的通信; 11A-E。 所述子节点还设置有至少一个发射和接收覆盖天线,以在至少一个地理次要覆盖区域a中产生覆盖; a-c,以及选择所述节点之一以扩展所述地理主覆盖区域A-B的控制机制; 节点11A-B的A-E; 11A-E包括地理二级覆盖区域a; a-c的子节点。 本发明还涉及蜂窝通信网络,以及用于在蜂窝通信网络中产生覆盖的方法。

    MEDICAL CLOSURE DEVICE
    26.
    发明申请
    MEDICAL CLOSURE DEVICE 有权
    医疗闭合装置

    公开(公告)号:US20120245535A1

    公开(公告)日:2012-09-27

    申请号:US13499621

    申请日:2010-10-01

    CPC classification number: A61F5/445 A61F2005/4455 A61F2005/4486

    Abstract: A medical closure device serves for coupling to a discharge opening of a device protruding from a mammalian body. The medical closure device includes a coupling part for engaging a part of the device protruding from the mammalian body. The coupling part is a circumferential flexible member delimiting a coupling opening configurable between a relaxed configuration where the coupling opening cannot pass over the medical device and a stressed configuration where the coupling opening of the coupling part can pass over the medical device. The coupling part has a securing member for securing the coupling part to a closure part, such as a cap, an ostomy bag, a catheter, or an irrigation device, for subsequent closure of a discharge opening.

    Abstract translation: 医疗闭合装置用于联接到从哺乳动物身体突出的装置的排出口。 医疗闭合装置包括用于接合从哺乳动物身体突出的装置的一部分的联接部分。 连接部分是周向柔性部件,其限定联接开口,其可配置在联接开口不能通过医疗装置的松弛构型和联接部件的联接开口可以越过医疗装置的应力配置。 联接部件具有固定构件,用于将联接部件固定到封闭部件,例如帽,造口袋,导管或冲洗装置,用于随后关闭排放口。

    Method for compensating a radiation beam by beam steering
    27.
    发明授权
    Method for compensating a radiation beam by beam steering 有权
    通过光束转向补偿辐射束的方法

    公开(公告)号:US08260336B2

    公开(公告)日:2012-09-04

    申请号:US12665627

    申请日:2007-06-21

    CPC classification number: H01Q1/005 H01Q1/246 H01Q3/30

    Abstract: The present invention relates to methods for adjusting a radiation beam pattern of an antenna arrangement providing coverage in an area. The antenna arrangement comprises an antenna having at least one array of antenna elements connected to a distribution network configured to generate the radiation beam pattern. The method comprises: arranging the antenna elements of said array in at least one column in an antenna plane in relation to a reference plane, each column comprising multiple antenna elements arranged in at least two sub-panels; arranging a motion sensor to the antenna arrangement, said motion sensor is configured to detect deviation of the antenna elements relative the reference plane; and adjusting a beam shape of the radiation beam pattern based on the detected deviation of the antenna to maintain coverage in the area by controlling the distribution network. The invention also relates to an antenna arrangement and base station.

    Abstract translation: 本发明涉及用于调整在一个区域中提供覆盖的天线装置的辐射束图案的方法。 天线装置包括天线,天线具有连接到被配置为产生辐射束图案的分配网络的天线元件的至少一个阵列。 该方法包括:将所述阵列的天线元件相对于参考平面布置在天线平面中的至少一列中,每列包括布置在至少两个子面板中的多个天线元件; 将运动传感器布置到天线装置,所述运动传感器被配置为检测天线元件相对于参考平面的偏差; 以及基于检测到的天线的偏差来调整辐射束图案的波束形状,以通过控制分布网络来保持该区域中的覆盖。 本发明还涉及一种天线装置和基站。

    Dual polarized antenna with null-fill
    28.
    发明授权
    Dual polarized antenna with null-fill 有权
    具有零填充的双极化天线

    公开(公告)号:US08212732B2

    公开(公告)日:2012-07-03

    申请号:US12598817

    申请日:2007-05-04

    CPC classification number: H01Q21/24 H01Q1/246 H01Q13/106 H01Q21/08

    Abstract: The present invention relates to a dual polarized array antenna comprising at least two dual polarized antenna elements being arranged for radiating electromagnetic energy having a first polarization, constituting a first antenna radiation pattern, via a connection to a first antenna port, and electromagnetic energy having a second polarization, constituting a second antenna radiation pattern, via a connection to a second antenna port, the second polarization being orthogonal to the first polarization, the first antenna radiation pattern and second antenna radiation pattern each having a main beam and a number of side-lobes with nulls. The array antenna comprises at least one further dual polarized antenna element arranged for radiating electromagnetic energy having two mutually orthogonal polarizations, constituting further antenna radiation patterns, via respective connections to the first antenna port and the second antenna port, where the polarization of said at least one further dual polarized antenna element that is associated with the first antenna port deviates from the first polarization such that said at least one null of the first antenna pattern is at least partly filled.

    Abstract translation: 双极化阵列天线技术领域本发明涉及一种双极化阵列天线,其包括至少两个双极化天线元件,其被布置用于通过与第一天线端口的连接来辐射构成第一天线辐射图案的具有第一极化的电磁能,以及具有 第二极化,通过与第二天线端口的连接构成第二天线辐射图,所述第二极化与第一极化正交,第一天线辐射图和第二天线辐射图均具有主光束和多个侧光, 裂片带零点。 阵列天线包括至少一个另外的双极化天线元件,其布置成经由到第一天线端口和第二天线端口的相应连接辐射具有两个相互正交偏振的电磁能,构成另外的天线辐射图,其中所述至少的极化 与第一天线端口相关联的一个另外的双极化天线元件偏离第一极化,使得第一天线图案的至少一个零点至少部分地被填充。

    PERCUTANEOUS IMPLANT AND OSTOMY METHOD
    29.
    发明申请
    PERCUTANEOUS IMPLANT AND OSTOMY METHOD 有权
    PERCUTANEOUS IMPLANT和OSTOMY方法

    公开(公告)号:US20120123361A1

    公开(公告)日:2012-05-17

    申请号:US13266876

    申请日:2010-04-28

    CPC classification number: A61F5/445 Y10T29/49826

    Abstract: A percutaneous ostomy implant for implantation into the abdominal wall of a patient. The implant has a cylindrical part for mounting an external detachable device thereto, an ingrowth mesh and a circular flange for anchoring the implant. The cylindrical part and circular flange are attached to opposite ends of the ingrowth mesh. The ingrowth mesh is arranged such that when the implant is implanted in the abdominal wall of a patient, the epidermis meets the ingrowth mesh and is able to attach therethrough directly to serosal tissue of a bowel segment inside the implant.

    Abstract translation: 用于植入患者腹壁的经皮造口植入物。 植入物具有用于将外部可拆卸装置安装到其上的圆柱形部分,向内生长网和用于锚定植入物的圆形凸缘。 圆柱形部分和圆形凸缘连接到向内生长网的相对端。 向内生长网布置成使得当将植入物植入患者的腹壁时,表皮与内生网相遇并且能够直接附着到植入物内的肠段的浆膜组织中。

    ANTENNA DEVICE FOR A RADIO BASE STATION IN A CELLULAR TELEPHONY SYSTEM
    30.
    发明申请
    ANTENNA DEVICE FOR A RADIO BASE STATION IN A CELLULAR TELEPHONY SYSTEM 审中-公开
    用于无线电基站的天线装置在蜂窝电话系统中

    公开(公告)号:US20120108297A1

    公开(公告)日:2012-05-03

    申请号:US13347206

    申请日:2012-01-10

    Abstract: The invention discloses an antenna device for a radio base station in a cellular telephony system, which comprises a first and a second input connection for a first (D1) and a second (D2) data stream, and a first and a second polarization former, one for each of said data streams. The device also comprises a first and a second antenna of respective first and second polarizations, and one amplifier each. The device also comprises a first and a second combiner, so that the outputs from the polarization formers may be combined as input to each of the first and second antennas.

    Abstract translation: 本发明公开了一种用于蜂窝电话系统中的无线电基站的天线装置,其包括用于第一(D1)和第二(D2)数据流的第一和第二输入连接以及第一和第二极化成型器, 每个所述数据流一个。 该装置还包括各自的第一和第二偏振的第一和第二天线以及每个一个放大器。 该装置还包括第一和第二组合器,使得来自偏振成形器的输出可以被组合为第一和第二天线中的每一个的输入。

Patent Agency Ranking