Abstract:
The disclosure describes compounds of formula I, wherein the wedged bonds, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof; and methods of using such compounds useful in the treatment of cancer and conditions affected by inhibition of angiogenesis. Also provided, are processes for the preparation of formula I, by reacting formula I with other compounds; and processes for the preparation of a pharmaceutical formulation by bringing into association, a compound of formula I, with therapeutic agents and/or a pharmaceutically-acceptable adjuvant, diluent, or carrier.
Abstract:
A percutaneous ostomy implant for implantation into the abdominal wall of a patient is provided, which includes a connecting member for mounting an external detachable device thereto; a first tubular ingrowth member depending from the connecting member; and a second tubular ingrowth member depending from the connecting member and being radially outwardly spaced from the first tubular ingrowth member. The first tubular ingrowth member is configured and dimensioned to receive a bowel segment within it to allow the stoma and serosal tissue of that bowel segment to infiltrate the first tubular ingrowth member. The second tubular member is configured and dimensioned to abut dermal tissue to allow the dermal tissue to infiltrate the second tubular ingrowth member, thereby securing and sealing the ostomy implant to the dermis.
Abstract:
An implant for percutaneous implantation through the abdominal wall for encircling and engaging an externalized length of a body duct of a human or animal patient. The implant has an exterior ring section protruding outwardly from the abdominal wall with a free end which serves for mounting of a detachable device, and an interior section extending through the abdominal wall and inside the patient for internal fixation of the implant. The exterior ring section and interior section have a common axis. The internal circumference of at least a part of the exterior ring section above the interior section is arranged with a biocompatible, integrated ingrowth means for the exterior surface of the body duct wall.
Abstract:
An antenna arrangement comprising an input/output connection and a first and a second tuning network with different transfer functions. The arrangement additionally comprises an antenna and a switch for connecting the input/output connection of the arrangement to one of said tuning networks, with a second switch for connecting the antenna of the arrangement to the tuning network to which the input/output connection of the arrangement has been connected. The arrangement comprises a sensor for sensing a form factor of the arrangement or of an apparatus in which the arrangement is used, and said sensor can be used for influencing said first and second switches, so that a device which has been connected to the arrangement may be connected to the antenna via a tuning network optimal for the current form factor of the arrangement.
Abstract:
A sub-node, such as a repeater station or relay station, equipped with a multi-beam sub-node link antenna. The beams of the sub-node link antenna allow communication between the sub-node and at least two nodes (access points/base stations) 11A-B; 11A-E. The sub-node is further provided with at least one transmitting and receiving coverage antenna to generate coverage in at least one geographical secondary coverage area a; a-c, and a control mechanism that selects one of the nodes to extend the geographical primary coverage area A-B; A-E of the node 11A-B; 11A-E to include the geographical secondary coverage area a; a-c of the sub-node. The invention is also related to a cellular communication network, and a method for generating coverage in a cellular communication network.
Abstract:
A medical closure device serves for coupling to a discharge opening of a device protruding from a mammalian body. The medical closure device includes a coupling part for engaging a part of the device protruding from the mammalian body. The coupling part is a circumferential flexible member delimiting a coupling opening configurable between a relaxed configuration where the coupling opening cannot pass over the medical device and a stressed configuration where the coupling opening of the coupling part can pass over the medical device. The coupling part has a securing member for securing the coupling part to a closure part, such as a cap, an ostomy bag, a catheter, or an irrigation device, for subsequent closure of a discharge opening.
Abstract:
The present invention relates to methods for adjusting a radiation beam pattern of an antenna arrangement providing coverage in an area. The antenna arrangement comprises an antenna having at least one array of antenna elements connected to a distribution network configured to generate the radiation beam pattern. The method comprises: arranging the antenna elements of said array in at least one column in an antenna plane in relation to a reference plane, each column comprising multiple antenna elements arranged in at least two sub-panels; arranging a motion sensor to the antenna arrangement, said motion sensor is configured to detect deviation of the antenna elements relative the reference plane; and adjusting a beam shape of the radiation beam pattern based on the detected deviation of the antenna to maintain coverage in the area by controlling the distribution network. The invention also relates to an antenna arrangement and base station.
Abstract:
The present invention relates to a dual polarized array antenna comprising at least two dual polarized antenna elements being arranged for radiating electromagnetic energy having a first polarization, constituting a first antenna radiation pattern, via a connection to a first antenna port, and electromagnetic energy having a second polarization, constituting a second antenna radiation pattern, via a connection to a second antenna port, the second polarization being orthogonal to the first polarization, the first antenna radiation pattern and second antenna radiation pattern each having a main beam and a number of side-lobes with nulls. The array antenna comprises at least one further dual polarized antenna element arranged for radiating electromagnetic energy having two mutually orthogonal polarizations, constituting further antenna radiation patterns, via respective connections to the first antenna port and the second antenna port, where the polarization of said at least one further dual polarized antenna element that is associated with the first antenna port deviates from the first polarization such that said at least one null of the first antenna pattern is at least partly filled.
Abstract:
A percutaneous ostomy implant for implantation into the abdominal wall of a patient. The implant has a cylindrical part for mounting an external detachable device thereto, an ingrowth mesh and a circular flange for anchoring the implant. The cylindrical part and circular flange are attached to opposite ends of the ingrowth mesh. The ingrowth mesh is arranged such that when the implant is implanted in the abdominal wall of a patient, the epidermis meets the ingrowth mesh and is able to attach therethrough directly to serosal tissue of a bowel segment inside the implant.
Abstract:
The invention discloses an antenna device for a radio base station in a cellular telephony system, which comprises a first and a second input connection for a first (D1) and a second (D2) data stream, and a first and a second polarization former, one for each of said data streams. The device also comprises a first and a second antenna of respective first and second polarizations, and one amplifier each. The device also comprises a first and a second combiner, so that the outputs from the polarization formers may be combined as input to each of the first and second antennas.