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    A2B adenosine receptor antagonists
    22.
    发明申请
    A2B adenosine receptor antagonists 有权
    A2B腺苷受体拮抗剂

    公开(公告)号：US20050119287A1

    公开(公告)日：2005-06-02

    申请号：US10973167

    申请日：2004-10-26

    申请人： Rao Kalla ,  Elfatih Elzein ,  Tim Marquart ,  Thao Perry ,  Xiaofen Li ,  Jeff Zablocki

    发明人： Rao Kalla ,  Elfatih Elzein ,  Tim Marquart ,  Thao Perry ,  Xiaofen Li ,  Jeff Zablocki

    IPC分类号： A61K31/519 ,  C07D487/02 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： Disclosed are novel compounds that are A2B adenosine receptor antagonists having the following structure: wherein R1 and R2 are independently chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl, and R4 is an optionally substituted heteroaryl moiety. The compounds of the invention are useful for treating various disease states, including asthma, chronic obstructive pulmonary disorder, pulmonary inflammation, emphysema, diabetic disorders, inflammatory gastrointestinal tract disorders, immunological/inflammatory disorders, cardiovascular diseases, neurological disorders, and diseases related to angiogenesis.

    摘要翻译： 公开了作为具有以下结构的A 2 B 2腺苷受体拮抗剂的新化合物：其中R 1和R 2独立地选自氢，任选地 取代的烷基，任选取代的环烷基，任选取代的芳基和任选取代的杂芳基，R 4是任选取代的杂芳基部分。 本发明的化合物可用于治疗各种疾病状态，包括哮喘，慢性阻塞性肺病，肺部炎症，肺气肿，糖尿病，炎症性胃肠道疾病，免疫/炎性疾病，心血管疾病，神经系统疾病以及与血管发生有关的疾病 。