公开(公告)号：US20180030544A1

公开(公告)日：2018-02-01

申请号：US15651652

申请日：2017-07-17

Applicant: Myriad Genetics, Inc.

Inventor： Victor Abkevich ,  Kirsten Timms ,  Alexander Gutin

IPC: C12Q1/68 ,  A61K33/24 ,  G06F19/18

CPC classification number: C12Q1/6886 ,  A61K33/24 ,  C12Q1/6827 ,  C12Q1/6858 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/156 ,  G16B20/00 ,  C12Q2535/122 ,  C12Q2537/143

Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US20170198358A1

公开(公告)日：2017-07-13

申请号：US15388979

申请日：2016-12-22

Applicant: Myriad Genetics, Inc.

Inventor： Michael Bryan Warf ,  Benjamin Roa ,  Alexander Gutin ,  Darl Flake

IPC: C12Q1/68 ,  G06F19/20

CPC classification number: C12Q1/6886 ,  C12Q1/6851 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G16B20/00 ,  G16B25/00 ,  C12Q2537/165

Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.

公开(公告)号：US09388472B2

公开(公告)日：2016-07-12

申请号：US14307708

申请日：2014-06-18

Applicant: Myriad Genetics, Inc.

Inventor： Victor Abkevich ,  Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K31/282 ,  A61K33/24 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

Abstract translation: 本文件提供了评估样品（例如癌细胞）中存在杂合性（LOH）特征丧失的方法和材料。 例如，提供了用于确定细胞（例如，癌细胞）是否包含LOH标记的方法和材料。 还提供了用于鉴别具有同源性定向修复（HDR）缺陷的细胞（例如癌细胞）的材料和方法以及用于鉴定可能对特定癌症治疗方案作出反应的癌症患者的材料和方法。

公开(公告)号：US20150247208A1

公开(公告)日：2015-09-03

申请号：US14713636

申请日：2015-05-15

Applicant: Myriad Genetics, Inc.

Inventor： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: Biomarkers and methods using the biomarkers for classifying cancer in a patient (e.g., predicting the risk of cancer-specific death or cancer recurrence) are provided.

Abstract translation: 提供了使用生物标志物在患者中分类癌症的生物标志物和方法（例如，预测癌症特异性死亡或癌症复发的风险）。

公开(公告)号：US20140271546A1

公开(公告)日：2014-09-18

申请号：US14205965

申请日：2014-03-12

Applicant: Myriad Genetics, Inc.

Inventor： Bryan Warf ,  Benjamin Roa ,  Alexander Gutin ,  Darl Flake

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158

Abstract: Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.

Abstract translation: 公开了用于确定基因表达以及诊断和治疗黑素瘤的生物标志物，方法和系统的小组。

公开(公告)号：US20140212415A1

公开(公告)日：2014-07-31

申请号：US14172632

申请日：2014-02-04

Applicant: Myriad Genetics, Inc.

Inventor： Alexander Gutin ,  Srikanth Jammulapati ,  Susanne Wagner ,  Julia Reid ,  Darl Flake

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: Biomarkers, particularly hypoxia-related genes, and methods using the biomarkers for molecular classification of disease are provided.

Abstract translation: 提供了生物标志物，特别是缺氧相关基因，以及使用生物标志物进行疾病分子分类的方法。

公开(公告)号：US20140170139A1

公开(公告)日：2014-06-19

申请号：US14184392

申请日：2014-02-19

Applicant: Myriad Genetics, Inc.

Inventor： Alexander Gutin ,  Srikanth Jammulapati ,  Susanne Wagner

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C07K14/47 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: Biomarkers, particularly hypoxia-related genes, and methods using the biomarkers for molecular detection and classification of disease are provided.

Abstract translation: 提供了生物标志物，特别是缺氧相关基因，以及使用生物标志物进行分子检测和疾病分类的方法。

公开(公告)号：US20140162886A1

公开(公告)日：2014-06-12

申请号：US14109163

申请日：2013-12-17

Applicant: Myriad Genetics, Inc.

Inventor： Alexander Gutin ,  Kirsten Timms ,  Jerry Lanchbury

IPC: C12Q1/68 ,  G06F19/22

CPC classification number: C12Q1/6827 ,  C12Q1/6858 ,  C12Q1/6874 ,  C12Q1/6883 ,  G06F19/22 ,  C12Q2535/122 ,  C12Q2537/143

Abstract: Methods and systems for detecting allelic imbalance using nucleic acid sequencing are provided.

Abstract translation: 提供了使用核酸测序检测等位基因不平衡的方法和系统。

公开(公告)号：US20240301500A1

公开(公告)日：2024-09-12

申请号：US18277554

申请日：2022-02-24

Applicant: MYRIAD GENETICS, INC.

Inventor： Elisha Hughes ,  Alexander Gutin ,  Jerry Lanchbury ,  Susanne Wagner

IPC: C12Q1/6886 ,  C12Q1/6874

CPC classification number: C12Q1/6886 ,  C12Q1/6874 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: Provided herein are methods for assessing a risk of a trait in a subject, by selecting a plurality of ancestry-informative SNP markers based on objective design criteria, measuring a genotype of the subject, obtaining trait-associated SNP markers, and calculating a global polygenic risk score for the risk of the trait in the subject based on the plurality of ancestry-informative SNP markers and the trait-associated SNP markers. The trait can be risk of cancer. Also provided are methods for assessing ancestry of a subject.

公开(公告)号：US20230260658A1

公开(公告)日：2023-08-17

申请号：US17920013

申请日：2021-04-16

Applicant: Myriad Genetics, Inc.

Inventor： Dmitry Pruss ,  Alexander Gutin ,  Elisha Hughes ,  Jerry Lanchbury

IPC: G16H50/30 ,  G16B20/20 ,  G16B20/40 ,  G16B40/00

CPC classification number: G16H50/30 ,  G16B20/20 ,  G16B20/40 ,  G16B40/00

Abstract: Provided herein are methods for determining polygenic traits and risks for medical use, such as cancer traits and risks, as well as treating diseases for which risk is identified and/or assessed. Methods of this invention can provide a polygenic score which takes into account local ancestry through the ancestral origin of the alleles of risk loci. A polygenic score can provide surprisingly increased accuracy in determining polygenic traits and risks for ancestrally admixed populations.