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21.发明授权Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors 有权杂芳基和芳香哌嗪基氮杂环丁烷酰胺作为单酰基甘油脂肪酶抑制剂公开(公告)号：US08415341B2
公开(公告)日：2013-04-09
申请号：US12765617
申请日：2010-04-22
申请人： Kristen Chevalier , Jose Clemente , Scott Dax , Chris Flores , Li Liu , Mark Macielag , Mark McDonnell , Marina Nelen , Erica Nulton , Stephen Prouty , Matthew Todd , Sui-Po Zhang , Bin Zhu
发明人： Kristen Chevalier , Jose Clemente , Scott Dax , Chris Flores , Li Liu , Mark Macielag , Mark McDonnell , Marina Nelen , Erica Nulton , Stephen Prouty , Matthew Todd , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/551 , C07D401/06 , C07D401/14 , C07D403/12 , C07D409/14 , C07D417/12
CPC分类号： C07D413/14 , C07D205/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, r, R2 and Z are defined herein.
摘要翻译： 公开了用于治疗受到抑制MGL（包括疼痛）的疾病，综合征，病症和障碍的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，r，R 2和Z如本文所定义。
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公开(公告)号：US08399454B2
公开(公告)日：2013-03-19
申请号：US12765254
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , A61K31/55 , A61K31/5377 , C07D205/04 , C07D295/12 , C07D401/12 , C07D403/04 , C07D409/06 , C07D413/12
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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23.发明申请公开(公告)号：US20110015171A1
公开(公告)日：2011-01-20
申请号：US12765420
申请日：2010-04-22
申请人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/397 , C07D401/14 , C07D403/04 , C07D417/14 , C07D409/14 , A61P29/00 , A61P25/06 , A61P19/00 , A61P17/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中Y，Z，R 1和S在本文中定义。
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公开(公告)号：US20110015170A1
公开(公告)日：2011-01-20
申请号：US12765254
申请日：2010-04-22
申请人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/397 , C07D403/04 , C07D417/14 , C07D403/14 , A61P29/00 , A61P25/06 , A61P19/02 , A61P1/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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25.发明申请HETEROAROMATIC AND AROMATIC PIPERAZINYL AZETIDINYL AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS 有权异佛尔酮和维生素A亚胺基酰胺作为单糖胆碱酯酶抑制剂公开(公告)号：US20100324016A1
公开(公告)日：2010-12-23
申请号：US12765675
申请日：2010-04-22
申请人： Chris FLORES , Marina Nelen , Erica Nulton , Stephen Prouty , Matthew Todd , Sui-Po Zhang
发明人： Chris FLORES , Marina Nelen , Erica Nulton , Stephen Prouty , Matthew Todd , Sui-Po Zhang
IPC分类号： A61K31/496 , C07D401/14 , C07D403/12 , C07D413/14 , A61P29/00 , A61P1/04 , A61P25/00
CPC分类号： C07D413/14 , C07D205/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, W and are defined herein.
摘要翻译： 公开了用于治疗受到抑制MGL（包括疼痛）的疾病，综合征，病症和障碍的化合物，组合物和方法。 这样的化合物由式（I）表示如下：其中R1，W和本文定义。
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公开(公告)号：US20100324014A1
公开(公告)日：2010-12-23
申请号：US12765103
申请日：2010-04-22
申请人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan BIAN , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D403/04 , C07D417/14 , A61K31/541 , A61P29/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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公开(公告)号：US20100324011A1
公开(公告)日：2010-12-23
申请号：US12765018
申请日：2010-04-22
申请人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人： Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号： A61K31/496 , C07D403/04 , C07D417/14 , C07D409/14 , C07D401/14 , C07D403/14 , A61P29/00
CPC分类号： C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
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28.发明授权Neuroblastoma cell lines expressing the α2δ subunit of calcium channels and methods therefore 失效表达钙通道的α2delta亚基的神经母细胞瘤细胞系和方法因此公开(公告)号：US06838249B2
公开(公告)日：2005-01-04
申请号：US10401895
申请日：2003-03-28
申请人： Sui-Po Zhang , Susan K. Yagel , Ellen E. Codd
发明人： Sui-Po Zhang , Susan K. Yagel , Ellen E. Codd
IPC分类号： G01N33/50 , A61K31/197 , A61K45/00 , A61P25/00 , A61P25/08 , C12N5/09 , C12Q1/02 , G01N33/15 , G01N33/68 , G01N33/574 , G01N33/53
CPC分类号： G01N33/6872 , C12N5/0693 , C12N2503/02 , C12N2510/04 , G01N2500/10
摘要： The present invention provides methods for identifying test substances that bind to the α2δ subunit of a calcium channel.
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