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25 条记录 (耗时 0.031 秒)

    Prodrugs of etoposide and etoposide analogs
    22.
    发明授权
    Prodrugs of etoposide and etoposide analogs 失效
    依托泊苷和依托泊苷类似物的前药

    公开(公告)号：US06713454B1

    公开(公告)日：2004-03-30

    申请号：US09474915

    申请日：1999-12-31

    申请人： Nnochiri Ekwuribe ,  Christopher H. Price ,  Tatyana A. Dyakonov

    发明人： Nnochiri Ekwuribe ,  Christopher H. Price ,  Tatyana A. Dyakonov

    IPC分类号： A61K31704

    CPC分类号： A61K47/60

    摘要： The present invention provides amphiphilic prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable oral drug delivery and/or delivery of drugs across the blood brain barrier into the central nervous system.

    摘要翻译： 本发明提供了包含与PEG-低聚物/聚合物缀合的治疗化合物的两亲前药，以及使用所述前体药物以使药物能够穿过血脑屏障进入中枢神经系统的口服药物递送和/或递送的方法。

    Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent
    25.
    发明授权
    Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent 失效
    在没有溶剂的情况下从纤维植物中提取植物化学物质的方法

    公开(公告)号：US5756098A

    公开(公告)日：1998-05-26

    申请号：US571231

    申请日：1995-12-12

    申请人： Christopher H. Price ,  Dale Hedtke ,  Geoffrey N. Richards ,  Michael S. Tempesta

    发明人： Christopher H. Price ,  Dale Hedtke ,  Geoffrey N. Richards ,  Michael S. Tempesta

    IPC分类号： C08B37/14 ,  C07D311/40 ,  C08B37/00 ,  D21C1/10 ,  D21C5/00 ,  A01N65/00 ,  A61K35/78 ,  B30B13/00 ,  C07G1/00

    CPC分类号： D21C1/10 ,  C07D311/40 ,  C08B37/0036 ,  C08B37/006 ,  D21C5/00

    摘要： Methods and apparatus are provided for the recovery of organic compounds from fibrous plant materials. Organic compounds which can be recovered from the fibrous plant materials include plant metabolites, such as arabinogalactan and phenols, which can be isolated from the wood, for example, of the Western Larch and Tamarack tree varieties. In addition to the recovery of organic compounds from wood, fibrous wood products also may be isolated, in the form of a clean fiber that can be used, for example, as raw material in wood processing applications or in the manufacture of high quality paper products. In one embodiment, a fibrous plant material first is compressed, to recover a liquid exudate and a first pressed plant fiber product. Optionally, the fibrous plant material, such as wood particles, is compressed in the substantial absence of any added solvent, to produce a pure normal liquid exudate and a first pressed plant product. The first plant fiber product then may be impregnated with, for example, an aqueous solvent, to recover an extract liquor and impregnated plant fiber. The impregnated plant fiber then is compressed to recover a liquid pressate and a second pressed fiber product. Using these methods, in one embodiment, a substantially pure arabinogalactan exudate and a wood fiber product can be recovered from wood of the genus Larix, with minimal coextraction of phenols. Additionally, a variety of different plant metabolites may be isolated and/or identified from different kinds of woody plants using the methods and apparatus.

    摘要翻译： 提供了从纤维植物材料回收有机化合物的方法和装置。 可以从纤维性植物材料回收的有机化合物包括植物代谢物，例如阿拉伯半乳聚糖和酚，其可以从木材例如西部落叶松和Tamarack树品种分离。 除了从木材中回收有机化合物之外，纤维木制品也可以分离成干净纤维的形式，例如可以用作木材加工应用中的原料或用于制造高品质纸制品 。 在一个实施方案中，首先将纤维状植物材料压缩，以回收液体渗出物和第一受压植物纤维产品。 任选地，基本上没有任何添加的溶剂，纤维状植物材料如木颗粒被压缩，以产生纯正常液体渗出物和第一压制植物产品。 然后可以用例如水性溶剂浸渍第一植物纤维产品，以回收提取液和浸渍的植物纤维。 然后将浸渍的植物纤维压缩以回收液体压制物和第二压制纤维产品。 使用这些方法，在一个实施方案中，基本上纯的阿拉伯半乳聚糖渗出物和木纤维产物可以通过酚的最小共萃取从落叶松的木材中回收。 另外，各种不同的植物代谢物可以使用方法和装置从不同种类的木本植物中分离和/或鉴定。