公开(公告)号：US07253299B2

公开(公告)日：2007-08-07

申请号：US10432288

申请日：2002-07-10

申请人： Yasuhiro Iida ,  Hajime Manabe ,  Yasuyoshi Ueda

发明人： Yasuhiro Iida ,  Hajime Manabe ,  Yasuyoshi Ueda

IPC分类号： C07C229/00 ,  C07C51/42

CPC分类号： C07C231/24 ,  C07C233/47

摘要： A process for purifying N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine which comprises subjecting N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine contaminated with impurities to crystallization from a solvent comprising a water-soluble non-protic organic solvent, thereby removing the impurities into the mother liquor and giving crystals of N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine, according to which N2-(1(S)-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine having a high quality can be obtained in a high yield and a high productivity and which is suitable for practice on an industrial scale.

摘要翻译： 一种纯化N 2 - （1（S） - 乙氧基羰基-3-苯基丙基）-N 6 - 三氟乙酰基-L-赖氨酸的方法，其包括使N 2 - 被杂质污染的（1（S） - 乙氧基羰基-3-苯基丙基）-N 6 - 三氟乙酰基-L-赖氨酸从包含水溶性非质子有机物 溶剂，从而将杂质除去到母液中，得到N 2 - （1（S） - 乙氧基羰基-3-苯基丙基）-N 6 - 三氟乙酰基-L - 赖氨酸，其中具有高质量的N 2 - （1（S） - 乙氧基羰基-3-苯基丙基）-N 6 - 三氟乙酰基-L-赖氨酸可以是 以高产量和高生产率获得，适用于工业规模的实践。

公开(公告)号：US5929284A

公开(公告)日：1999-07-27

申请号：US722102

申请日：1996-12-18

申请人： Akira Nishiyama ,  Tadashi Sugawa ,  Hajime Manabe ,  Kenji Inoue ,  Noritaka Yoshida

发明人： Akira Nishiyama ,  Tadashi Sugawa ,  Hajime Manabe ,  Kenji Inoue ,  Noritaka Yoshida

IPC分类号： C07C29/143 ,  C07C45/48 ,  C07C269/06 ,  C07C319/20 ,  C07C323/43 ,  C07D303/36 ,  C07C45/00

CPC分类号： C07D303/36 ,  C07C269/06 ,  C07C29/143 ,  C07C319/20 ,  C07C45/48

摘要： Processes for efficiently producing .alpha.-halo ketones, .alpha.-halohydrins and epoxides on an industrial scale. The prosesses include one for producing an .alpha.-halo ketone of general formula (3) by decarboxylating a product of reaction between a carboxilic acid derivative of general formula (1) and a metal enolate prepared from an .alpha.-haloacetic acid of general formula (2) or an acceptable salt thereof, one for producing an by reducing the .alpha.-halo ketone (3), and one for producing an epoxide (13) by treating the .alpha.-halohydrin (11) with a base to effect ring closure. The above prosesses are particularly suitable for producing optically active .alpha.-halo ketones, .alpha.-halohydrins and epoxides from the corresponding .alpha.-amino acid derivatives. ##STR1##

摘要翻译： PCT No.PCT / JP96 / 00212 Sec。 371日期：1996年12月18日 102（e）1996年12月18日日期PCT 1996年2月2日PCT PCT。 第WO96 / 23756号公报 日期1996年8月8日工业规模高效生产α-卤代酮，α-卤代醇和环氧化物的方法。 前药包括通过使通式（1）的羧酸衍生物与由通式（2）的α-卤代乙酸制备的金属烯醇化物脱羧的方法来制备通式（3）的α-卤代酮， ）或其可接受的盐，其中通过用碱来还原α-卤代酮（3）和通过用碱处理α-卤代醇（11）来制备环氧化物（13）来制备，以实现闭环。 上述产品特别适用于从相应的α-氨基酸衍生物制备光学活性的α-卤代酮，α-卤代醇和环氧化物。

公开(公告)号：US5121669A

公开(公告)日：1992-06-16

申请号：US556954

申请日：1990-07-20

申请人： Akio Iba ,  Yoshiyuki Murata ,  Hajime Manabe

发明人： Akio Iba ,  Yoshiyuki Murata ,  Hajime Manabe

IPC分类号： G10H1/46 ,  G10H1/00 ,  G10H1/02 ,  G10H1/043 ,  G10H1/053 ,  G10H1/10 ,  G10H1/14 ,  G10H1/34 ,  G10H3/18

CPC分类号： G10H1/0091 ,  G10H1/10 ,  G10H1/342 ,  G10H3/18 ,  G10H2210/066 ,  G10H2210/191 ,  G10H2210/225 ,  G10H2210/235 ,  G10H2210/251 ,  G10H2210/281 ,  G10H2220/181 ,  G10H2220/301

摘要： An electronic stringed instrument employs a plurality of sensors or monitors for instrument performance. Preferred sensors or monitors include a detector for detecting that a string of the instrument is vibrated, an apparatus for evaluating a string-vibration strength or a string touch, an apparatus for discriminating a fret operation position on a fingerboard or a fundamental frequency of a vibration of the vibrated string, a tremolo arm sensor, and a string-bending sensor. These performance input parameters are assigned to various control functions for musical tones generated by a sound source and/or various control functions for effects added to these musical tones by an effector. The function assignment is preferably programmable. In an operation, a music control apparatus controls the sound source and/or effector in response to a performance monitor so that musical tones for the strings can be distinguished from each other or effects for the musical tones can be distinguished from each other. Therefore, a performance with the stringed instrument by a player can be fully expressed.