公开(公告)号：US20090105490A1

公开(公告)日：2009-04-23

申请号：US12218369

申请日：2008-07-14

Applicant: Nurit Perlman ,  Michal Rafilovich ,  Rinat Moshkovits-Kaptsan ,  Elena Ben Moha-Lerman ,  Revital Lifshitz-Liron

Inventor： Nurit Perlman ,  Michal Rafilovich ,  Rinat Moshkovits-Kaptsan ,  Elena Ben Moha-Lerman ,  Revital Lifshitz-Liron

IPC: C07D307/77

CPC classification number: C07D307/77

Abstract: An amorphous form of ramelteon is provided, as well as mixtures of amorphous and crystalline ramelteon. Also provided are methods of preparing amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, pharmaceutical compositions comprising amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, and methods of treatment of insomnia using the compositions of the invention.

Abstract translation: 提供了无定形形式的拉面，以及无定形和结晶拉米尔顿的混合物。 还提供了制备无定形拉米尔顿的方法以及无定形和结晶拉米尔顿的混合物，包含无定形拉米尔顿的药物组合物和无定形和结晶拉米尔顿的混合物的方法，以及使用本发明的组合物治疗失眠的方法。

公开(公告)号：US20090093627A1

公开(公告)日：2009-04-09

申请号：US12231438

申请日：2008-09-02

Applicant: Lorand Szabo ,  Laszlo Toth ,  Nurit Perlman

Inventor： Lorand Szabo ,  Laszlo Toth ,  Nurit Perlman

IPC: C07D205/08 ,  C12P17/10

CPC classification number: C12P17/10

Abstract: Processes of preparing an ezetimibe intermediate by microbial reduction and further converting the intermediate to ezetimibe are provided. Also provided is an ezetimibe intermediate with high diastereomeric excess.

Abstract translation: 提供了通过微生物还原制备依泽替米贝中间体并进一步将中间体转化为依泽替米贝的方法。 还提供了具有高非对映异构体过量的依泽替米贝中间体。

公开(公告)号：US07687642B2

公开(公告)日：2010-03-30

申请号：US11699659

申请日：2007-01-29

Applicant: Revital Lifshitz-Liron ,  Tamas Koltai ,  Judith Aronhime ,  Nurit Perlman ,  Sharon Avhar-Maydan

Inventor： Revital Lifshitz-Liron ,  Tamas Koltai ,  Judith Aronhime ,  Nurit Perlman ,  Sharon Avhar-Maydan

IPC: C07D209/12

CPC classification number: C07D209/12 ,  C07D209/24

Abstract: Provided are crystalline forms of fluvastatin sodium and processes for their preparation.

Abstract translation: 提供氟伐他汀钠的结晶形式及其制备方法。

公开(公告)号：US20090118518A1

公开(公告)日：2009-05-07

申请号：US12150949

申请日：2008-04-30

Applicant: Revital Lifshitz-Liron ,  Tamas Koltai ,  Judith Aronhime ,  Nurit Perlman ,  Sharon Avhar-Maydan

Inventor： Revital Lifshitz-Liron ,  Tamas Koltai ,  Judith Aronhime ,  Nurit Perlman ,  Sharon Avhar-Maydan

IPC: C07D209/04

CPC classification number: C07D209/12 ,  C07D209/24

Abstract: Provided are crystalline forms of fluvastatin sodium and processes for their preparation.

Abstract translation: 提供氟伐他汀钠的结晶形式及其制备方法。

公开(公告)号：US07414140B2

公开(公告)日：2008-08-19

申请号：US10872089

申请日：2004-06-18

Applicant: Revital Lifshitz-Liron ,  Tamas Koltai ,  Judith Aronhime ,  Nurit Perlman ,  Sharon Avhar-Maydan

Inventor： Revital Lifshitz-Liron ,  Tamas Koltai ,  Judith Aronhime ,  Nurit Perlman ,  Sharon Avhar-Maydan

IPC: C07D209/12

CPC classification number: C07D209/12 ,  C07D209/24

Abstract: Provided are polymorphic forms of fluvastatin sodium and processes for their preparation.

Abstract translation: 提供氟伐他汀钠的多晶型物质及其制备方法。

公开(公告)号：US20080114171A1

公开(公告)日：2008-05-15

申请号：US11890316

申请日：2007-08-03

Applicant: Tamas Koltai ,  Nurit Perlman ,  Tamar Nidam ,  Mili Abramov

Inventor： Tamas Koltai ,  Nurit Perlman ,  Tamar Nidam ,  Mili Abramov

IPC: C07D453/02 ,  A61P13/10

CPC classification number: C07D453/02 ,  C07D217/02

Abstract: Polymorphic forms of solifenacin base have been prepared and characterized. These polymorphic forms are particularly useful for preparing solifenacin salts.

Abstract translation: 已经制备和表征索非那新碱的多晶型。 这些多晶型对于制备索非那新盐特别有用。

公开(公告)号：US20080114029A1

公开(公告)日：2008-05-15

申请号：US11890264

申请日：2007-08-03

Applicant: Tamas Koltai ,  Nurit Perlman ,  Tamar Nidam ,  Dov Diller

Inventor： Tamas Koltai ,  Nurit Perlman ,  Tamar Nidam ,  Dov Diller

IPC: A61K31/47 ,  C07D217/02

CPC classification number: C07D453/02 ,  C07D217/02

Abstract: Polymorphic forms of 1(S)-phenyl-1,2,3,4-tetrahydroisoquinoline have been prepared and characterized. These polymorphic forms are particularly useful for preparing solifenacin salts.

Abstract translation: 已经制备并表征了1（S） - 苯基-1,2,3,4-四氢异喹啉的多晶型。 这些多晶型对于制备索非那新盐特别有用。

公开(公告)号：US20080114028A1

公开(公告)日：2008-05-15

申请号：US11881161

申请日：2007-07-24

Applicant: Tamas Koltai ,  Tamar Nidam ,  Eyal Gilboa ,  Nurit Perlman ,  Michael Pinhasov ,  Mili Abramov

Inventor： Tamas Koltai ,  Tamar Nidam ,  Eyal Gilboa ,  Nurit Perlman ,  Michael Pinhasov ,  Mili Abramov

IPC: A61K31/4745 ,  C07D453/02

CPC classification number: C07D453/02

Abstract: Polymorphic forms of solifenacin have been prepared and characterized. These polymorphic forms are particularly useful in pharmaceutical compositions.

Abstract translation: 已经制备和表征索非那新的多晶型形式。 这些多晶型在药物组合物中特别有用。

公开(公告)号：US20070173528A1

公开(公告)日：2007-07-26

申请号：US11645021

申请日：2006-12-21

Applicant: Nurit Perlman ,  Tamar Nidam

Inventor： Nurit Perlman ,  Tamar Nidam

IPC: A61K31/4745 ,  A61K31/47 ,  C07D453/02 ,  C07D217/02

CPC classification number: C07D217/06 ,  C07D453/02

Abstract: Provided are new intermediates of solifenacin and methods for their preparation, as well as methods of preparing solifenacin and solifenacin succinate.

Abstract translation: 提供索非那新的新中间体及其制备方法，以及制备索非那新和索非那新琥珀酸酯的方法。

公开(公告)号：US20060094883A1

公开(公告)日：2006-05-04

申请号：US11250267

申请日：2005-10-13

Applicant: Nurit Perlman ,  Eyal Gilboa

Inventor： Nurit Perlman ,  Eyal Gilboa

IPC: C07D403/02

CPC classification number: C07D235/14 ,  C07D235/18

Abstract: Provided are processes for preparing telmisartan alkyl ester and telmisartan using environmentally friendly organic solvents that are easily removed from the reaction mixture, wherein a telmisartan alkyl ester is isolated and hydrolyzed to form telmisartan or the telmisartan is prepared using a synthesis in a single reaction vessel.