利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

54 条记录 (耗时 0.069 秒)

    ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY
    26.
    发明申请
    ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY 有权
    具有增强作用时间和降低免疫原性的工程多糖

    公开(公告)号：US20160207974A1

    公开(公告)日：2016-07-21

    申请号：US14837705

    申请日：2015-08-27

    申请人： Mary Erickson ,  David C. Litzinger ,  Soumitra S. Ghosh ,  Zijian Guo ,  Caroline Ekblad ,  Jonathan D. Roth

    发明人： Mary Erickson ,  David C. Litzinger ,  Soumitra S. Ghosh ,  Zijian Guo ,  Caroline Ekblad ,  Jonathan D. Roth

    IPC分类号： C07K14/575 ,  C07K14/315

    CPC分类号： C07K14/5759 ,  A61K38/00 ,  A61K38/22 ,  A61K38/2264 ,  C07K14/315 ,  C07K14/575 ,  C07K2319/31 ,  C07K2319/70

    摘要： Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.

    摘要翻译： 提供化合物尤其具有良好的作用持续时间，高效力和/或方便的给药方案，包括每周给药一次。 所述化合物是结合一种或多种生物活性多肽的白蛋白结合结构域的工程多肽。 还提供了包括脂肪营养不良，血脂异常，高脂血症，超重，肥胖，下丘脑闭经，阿尔茨海默病，瘦素缺乏症，脂肪肝疾病或糖尿病（包括I型和II型）的疾病和病症的药物组合物和治疗方法。 可以通过本文所述的化合物和方法治疗的其它疾病和病症包括非酒精性脂肪性肝炎（NASH）和非酒精性脂肪性肝病（NAFLD），代谢综合征X和亨廷顿氏病。

    ENGINEERED POYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY
    28.
    发明申请
    ENGINEERED POYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY 审中-公开
    具有增强作用持续时间和降低免疫原性的工程应用

    公开(公告)号：US20140256621A1

    公开(公告)日：2014-09-11

    申请号：US14129793

    申请日：2012-07-03

    申请人： Mary Erickson ,  David C. Litzinger ,  Soumitra S. Ghosh ,  Zijian Guo ,  Caroline Ekbland ,  Jonathan David Roth

    发明人： Mary Erickson ,  David C. Litzinger ,  Soumitra S. Ghosh ,  Zijian Guo ,  Caroline Ekbland ,  Jonathan David Roth

    IPC分类号： C07K14/575 ,  C07K14/315

    CPC分类号： C07K14/5759 ,  A61K38/00 ,  A61K38/22 ,  A61K38/2264 ,  C07K14/315 ,  C07K14/575 ,  C07K2319/31 ,  C07K2319/70

    摘要： Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.

    摘要翻译： 提供化合物尤其具有良好的作用持续时间，高效力和/或方便的给药方案，包括每周给药一次。 所述化合物是结合一种或多种生物活性多肽的白蛋白结合结构域的工程多肽。 还提供了包括脂肪营养不良，血脂异常，高脂血症，超重，肥胖，下丘脑闭经，阿尔茨海默病，瘦素缺乏症，脂肪肝疾病或糖尿病（包括I型和II型）的疾病和病症的药物组合物和治疗方法。 可以通过本文所述的化合物和方法治疗的其它疾病和病症包括非酒精性脂肪性肝炎（NASH）和非酒精性脂肪性肝病（NAFLD），代谢综合征X和亨廷顿氏病。

    C-terminal amidation of polypeptides
    30.
    发明授权
    C-terminal amidation of polypeptides 有权
    多肽的C-末端酰胺化

    公开(公告)号：US09249181B2

    公开(公告)日：2016-02-02

    申请号：US13822821

    申请日：2011-09-08

    申请人： Chengzao Sun ,  Behrouz Bruce Forood ,  Gary Luo ,  Soumitra S. Ghosh

    发明人： Chengzao Sun ,  Behrouz Bruce Forood ,  Gary Luo ,  Soumitra S. Ghosh

    IPC分类号： C07K1/00 ,  C07K1/107 ,  C07D311/88 ,  C07C211/27

    CPC分类号： C07K1/003 ,  C07C211/27 ,  C07D311/88 ,  C07K1/107

    摘要： There are provided compounds and methods for amidating the C-terminus of a polypeptide. The methods include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary molecules under conditions suitable to produce a polypeptide adduct which includes the auxiliary molecule chemically bound at the C-terminal of the polypeptide. The auxiliary molecule can be a substituted or unsubstituted 2-phenyl-2-amino ethanethiol, a substituted or unsubstituted 2-phenyl-2-amino ethaneselenol, or a substituted xanthene. In the subsequent step, a portion of the auxiliary molecule is removed from the C-terminal of the polypeptide adduct and leaving the amide nitrogen under conditions suitable to form a C-terminal free amide polypeptide.

    摘要翻译： 提供了用于酰胺化多肽的C末端的化合物和方法。 所述方法包括在适于产生多肽加合物的条件下使包含C-末端硫酯或C-末端硒酯的多肽与定义的一组辅助分子中的任何一种反应，所述多肽加合物包括在C末端化学键合的辅助分子 多肽。 辅助分子可以是取代或未取代的2-苯基-2-氨基乙硫醇，取代或未取代的2-苯基-2-氨基乙基硒酚或取代的呫吨。 在随后的步骤中，一部分辅助分子从多肽加合物的C末端除去，并在适于形成C末端游离酰胺多肽的条件下离开酰胺氮。