利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

37 条记录 (耗时 0.038 秒)

    Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
    24.
    发明授权
    Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them 失效
    即，间位取代的双芳基化合物，其制备方法，它们作为药物的用途，以及包含它们的药物制剂

    公开(公告)号：US06605625B2

    公开(公告)日：2003-08-12

    申请号：US09995771

    申请日：2001-11-29

    申请人： Stefan Peukert ,  Joachim Brendel ,  Horst Hemmerle ,  Heinz-Werner Kleemann

    发明人： Stefan Peukert ,  Joachim Brendel ,  Horst Hemmerle ,  Heinz-Werner Kleemann

    IPC分类号： C07D21381

    CPC分类号： C07D213/79 ,  C07C235/34 ,  C07C271/22 ,  C07D213/81 ,  C07D213/82

    摘要： Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters. Compounds of the invention include compounds of the formula I in which: A1, A2, A3, A4, A5, A6, A7 and A8 independently of one another are chosen from nitrogen, CH and CR(5), at least four of these groups being CH, and wherein all other variables are as defined here.

    摘要翻译： 正交的，间位取代的二芳基化合物，其制备方法，它们作为药物的用途，以及药物制剂，包括它们作为抗心律失常活性化合物的用途，例如用于治疗和预防心房心律失常，例如。 心房颤动（AF）或心房扑动。 本发明的化合物包括式Iin的化合物，其中：A1，A2，A3，A4，A5，A6，A7和A8彼此独立地选自氮，CH和CR（5），这些基团中的至少四个为 CH，并且其中所有其他变量如这里所定义。

    Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use
    28.
    发明授权
    Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use 有权
    具有杂芳基磺酰侧链的邻氨基苯甲酰胺，制备方法和用途

    公开(公告)号：US07235664B2

    公开(公告)日：2007-06-26

    申请号：US11052959

    申请日：2005-02-08

    申请人： Joachim Brendel ,  Thomas Boehme ,  Stefan Peukert ,  Heinz-Werner Kleemann

    发明人： Joachim Brendel ,  Thomas Boehme ,  Stefan Peukert ,  Heinz-Werner Kleemann

    IPC分类号： C07D215/36 ,  A61K31/47

    CPC分类号： C07D261/10 ,  A61K31/47 ,  A61K45/06 ,  C07D215/36 ,  C07D217/02 ,  C07D271/12 ,  C07D333/34 ,  C07D401/12 ,  C07D405/12 ,  A61K2300/00

    摘要： This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.

    摘要翻译： 本发明包括具有杂芳基磺酰侧链的邻氨基苯甲酰胺，其制备方法，它们作为药物或诊断助剂的用途，以及含有它们的药物制剂。 其中R 1至R 7具有权利要求中所述含义的式I化合物作用于Kv1.5钾通道并抑制在人心脏中心被称为超快速活化延迟整流剂的钾电流 。 因此，它们适合作为新的抗心律失常成分，例如用于治疗和预防心房心律失常，例如， 心房颤动（AF）或心房扑动。