公开(公告)号：US06372197B1

公开(公告)日：2002-04-16

申请号：US09721668

申请日：2000-11-27

Applicant: Paul D. Rubin

Inventor： Paul D. Rubin

IPC: A61K912

CPC classification number: A61K45/06 ,  A61K31/445 ,  Y10S514/826

Abstract: Methods and pharmaceutical compositions employing norastemizole and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma or the symptoms thereof. Also included are methods and compositions employing norastemizole and a decongestant for the treatment or prevention of inflammation or allergic disorders, such as asthma or the symptoms thereof.

公开(公告)号：US06362227B1

公开(公告)日：2002-03-26

申请号：US09507470

申请日：2000-02-22

Applicant: Thomas P. Jerussi ,  Paul D. Rubin

Inventor： Thomas P. Jerussi ,  Paul D. Rubin

IPC: A61K3119

CPC classification number: A61K31/137 ,  A61K31/00 ,  A61K31/165 ,  A61K31/192 ,  A61K31/415 ,  A61K31/43 ,  A61K31/435 ,  A61K31/46 ,  A61K31/465 ,  C07B2200/07 ,  C07C49/84 ,  C07D265/32 ,  A61K2300/00

Abstract: Methods of treating neuropathic pain, tinnitus, and related disorders are disclosed. These methods comprise the administration of optically pure R(−)-ketoprofen. Also disclosed are pharmaceutical compositions useful in the treatment of neuropathic pain and tinnitus which comprise optically pure R(−)-ketoprofen.

Abstract translation: 公开了治疗神经性疼痛，耳鸣和相关疾病的方法。 这些方法包括给予光学纯的R（ - ） - 酮洛芬。 还公开了可用于治疗包含光学纯的R（ - ） - 酮洛芬的神经性疼痛和耳鸣的药物组合物。

公开(公告)号：US6048879A

公开(公告)日：2000-04-11

申请号：US332196

申请日：1999-06-14

Applicant: Paul D. Rubin ,  Timothy J. Barberich

Inventor： Paul D. Rubin ,  Timothy J. Barberich

IPC: A61K31/445 ,  A61K31/4468 ,  A61P1/00 ,  A61P9/06 ,  A61P11/06 ,  A61P25/00 ,  A61P43/00

CPC classification number: A61K31/445 ,  A61K31/4468

Abstract: Methods for the prevention, treatment or management of apnea, apnea disorders, bulimia nervosa, irritable bowel syndrome, urinary incontinence, bradycardia, bradyarrhythmia, syncope, other disorders, or symptoms thereof using (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (-) stereoisomer.

Abstract translation: 使用（+）诺西沙必利或其药学上可接受的盐基本上预防，治疗或治疗呼吸暂停，呼吸暂停障碍，贪食症，肠易激综合征，尿失禁，心动过缓，缓慢性心律失常，晕厥，其他障碍或其症状 没有（ - ）立体异构体。

公开(公告)号：US06946464B2

公开(公告)日：2005-09-20

申请号：US10340957

申请日：2003-01-13

Applicant: Thomas P. Jerussi ,  Chrisantha H. Senanayake ,  Paul D. Rubin ,  Yaping Hong ,  Roger A. Bakale ,  Tingjian Xiang ,  Fran A. McConville

Inventor： Thomas P. Jerussi ,  Chrisantha H. Senanayake ,  Paul D. Rubin ,  Yaping Hong ,  Roger A. Bakale ,  Tingjian Xiang ,  Fran A. McConville

IPC: A61K9/20 ,  A61K9/48 ,  A61K31/4985 ,  A61P5/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30 ,  A61P25/32 ,  C07D487/04 ,  A61K31/50 ,  A61K31/495

CPC classification number: A61K31/4985 ,  A61K31/498 ,  C07B2200/07 ,  C07D487/04

Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.

Abstract translation: 本发明涉及包含外消旋的N-去甲基佐氮克隆，光学纯的（+） - N-去甲基佐匹克隆和光学纯的（ - ） - N-去甲基佐匹克隆的组合物，其用于治疗和预防哺乳动物的疾病和病症。 本发明进一步涉及制备N-去甲基异佐匹克隆，光学纯的（+） - N-去甲基佐匹克隆和光学纯的（ - ） - N-去甲基异佐匹克隆的新方法。

公开(公告)号：US06835740B2

公开(公告)日：2004-12-28

申请号：US10075617

申请日：2002-02-15

Applicant: Paul D. Rubin ,  Timothy J. Barberich

Inventor： Paul D. Rubin ,  Timothy J. Barberich

IPC: A61R31445

CPC classification number: A61K31/445 ,  A61K31/4468

Abstract: Methods for the prevention, treatment, or management of apnea, apnea disorders, bulimia, nervosa, irritable bowel syndrome, urinary incontinence, bradycardia, bradyarrhythmia, syncope, other disorders, or symptoms thereof using (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (−) stereoisomer.

Abstract translation: 使用（+）诺西沙必利或其药学上可接受的盐预防，治疗或治疗呼吸暂停，呼吸暂停障碍，贪食症，神经性，肠易激综合征，尿失禁，心动过缓，缓慢性心律失常，晕厥，其他障碍或其症状 ，基本上不含（ - ）立体异构体。

公开(公告)号：US06649183B2

公开(公告)日：2003-11-18

申请号：US09985099

申请日：2001-11-01

Applicant: Paul D. Rubin ,  Timothy J. Barberich

Inventor： Paul D. Rubin ,  Timothy J. Barberich

IPC: A61F1300

CPC classification number: A61K31/415 ,  A61K31/4178 ,  A61K31/00 ,  A61K2300/00

Abstract: Methods for the treatment, management, or prevention of apnea and apnea disorders, or symptoms thereof, using a therapeutically effective amount of substantially optically pure R(+) ondansetron, or a pharmaceutically acceptable salt thereof, substantially free of its S(−) stereoisomer.

公开(公告)号：US06620851B2

公开(公告)日：2003-09-16

申请号：US10062766

申请日：2002-02-05

Applicant: Thomas P. Jerussi ,  Paul D. Rubin

Inventor： Thomas P. Jerussi ,  Paul D. Rubin

IPC: A61K3119

CPC classification number: A61K31/137 ,  A61K31/00 ,  A61K31/165 ,  A61K31/192 ,  A61K31/415 ,  A61K31/43 ,  A61K31/435 ,  A61K31/46 ,  A61K31/465 ,  C07B2200/07 ,  C07C49/84 ,  C07D265/32 ,  A61K2300/00

Abstract: Methods of treating neuropathic pain, tinnitus, and related disorders are disclosed. These methods comprise the administration of optically pure R(−)-ketoprofen. Also disclosed are pharmaceutical compositions useful in the treatment of neuropathic pain and tinnitus which comprise optically pure R(−)-ketoprofen.

Abstract translation: 公开了治疗神经性疼痛，耳鸣和相关疾病的方法。 这些方法包括给予光学纯的R（ - ） - 酮洛芬。 还公开了可用于治疗包含光学纯的R（ - ） - 酮洛芬的神经性疼痛和耳鸣的药物组合物。

公开(公告)号：US06559165B1

公开(公告)日：2003-05-06

申请号：US09722391

申请日：2000-11-28

Applicant: Paul D. Rubin ,  Timothy J. Barberich

Inventor： Paul D. Rubin ,  Timothy J. Barberich

IPC: A61K31445

CPC classification number: A61K31/445 ,  A61K31/4468

Abstract: Methods for the prevention, treatment, or management of apnea, apnea disorders, bulimia nervosa, irritable bowel syndrome, urinary incontinence, bradycardia, bradyarrhythmia, syncope, other disorders, or symptoms thereof using (−) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (+) stereoisomer.

Abstract translation: 使用（ - ）诺西沙必利或其药学上可接受的盐的预防，治疗或治疗呼吸暂停，呼吸暂停障碍，贪食症，肠易激综合征，尿失禁，心动过缓，缓慢性心律失常，晕厥，其他障碍或其症状的方法， 基本上不含（+）立体异构体。

公开(公告)号：US06509353B1

公开(公告)日：2003-01-21

申请号：US09722395

申请日：2000-11-28

Applicant: Paul D. Rubin

Inventor： Paul D. Rubin

IPC: A61K31445

CPC classification number: A61K45/06 ,  A61K31/445 ,  A61K31/47 ,  A61K31/475 ,  A61K31/41 ,  A61K31/405 ,  A61K31/40 ,  A61K2300/00

Abstract: Methods and pharmaceutical compositions employing a terfenadine metabolite and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma, or symptoms thereof. Also included are methods and compositions employing a terfenadine metabolite, a leukotriene inhibitor, and a decongestant for the treatment or prevention of inflammation or allergic disorders, such as asthma, or symptoms thereof.

Abstract translation: 使用特非那定代谢物和白三烯抑制剂用于治疗或预防炎症或过敏性疾病如哮喘或其症状的方法和药物组合物。 还包括使用特非那定代谢物，白三烯抑制剂和减充血剂用于治疗或预防炎症或过敏性疾病如哮喘或其症状的方法和组合物。

公开(公告)号：US06465469B1

公开(公告)日：2002-10-15

申请号：US09545475

申请日：2000-04-07

Applicant: Timothy J. Barberich ,  Paul D. Rubin ,  William E. Yelle

Inventor： Timothy J. Barberich ,  Paul D. Rubin ,  William E. Yelle

IPC: A61K31525

CPC classification number: A61K31/496 ,  C07D249/12

Abstract: The S-isomer of the hydroxy metabolite of nefazodone, S-hydroxynefazodone, is an effective treatment for depression which does not give rise to the adverse effects associated with nefazodone. S-hydroxynefazodone is also useful in the treatment of migraine headaches, panic disorders, post traumatic stress disorder and sleep disorders.

Abstract translation: 奈法唑酮的羟基代谢物的S-异构体S-羟基芬那唑酮是抑制剂的有效治疗剂，其不会引起与奈法唑酮相关的不良反应。 S-羟基诺法唑酮也可用于治疗偏头痛，恐慌症，创伤后应激障碍和睡眠障碍。