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公开(公告)号：US06821986B2
公开(公告)日：2004-11-23
申请号：US10275057
申请日：2002-10-31
IPC分类号： C07D20914
CPC分类号： C07C279/36 , C07D339/04
摘要： Novel compounds of formula wherein the substituents are defined as in the specification and are useful for inhibiting neuronal NO synthase or inducible NO synthase as well as inhibiting lipidic peroxidation.
摘要翻译： 取代基的新型化合物如本说明书所定义，可用于抑制神经元NO合成酶或诱导型NO合酶以及抑制脂质过氧化。
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22.发明授权Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing same 失效脒衍生物，其制备和作为药物的应用和含有它们的药物组合物公开(公告)号：US06653312B1
公开(公告)日：2003-11-25
申请号：US09787467
申请日：2001-03-16
申请人： Serge Auvin , Pierre-Etienne Chabrier de Lassauniere , Jeremiah Harnett , Dominique Pons , Gérard Ulibarri
发明人： Serge Auvin , Pierre-Etienne Chabrier de Lassauniere , Jeremiah Harnett , Dominique Pons , Gérard Ulibarri
IPC分类号： C07D33336
CPC分类号： C07D409/12 , C07C217/84 , C07D333/20 , C07D333/36 , C07D333/38 , C07D409/14 , C07D417/12 , C07D473/08
摘要： Amidine compounds of the formula wherein the substituents are defined as in the application useful as NO-synthase enzyme inhibitors.
摘要翻译： 取代基中的取代基的脒化合物定义为可用作NO-合酶酶抑制剂的应用。
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23.发明授权Derivatives of 2-(iminomethyl) amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them 失效2-（亚氨基甲基）氨基 - 苯基的衍生物，它们的制备，它们作为药物的用途以及含有它们的药物组合物公开(公告)号：US06630461B2
公开(公告)日：2003-10-07
申请号：US09882264
申请日：2001-06-15
申请人： Pierre Etienne Chabrier de Lassauniere , Serge Auvin , Dennis Bigg , Michel Auguet , Jeremiah Harnett
发明人： Pierre Etienne Chabrier de Lassauniere , Serge Auvin , Dennis Bigg , Michel Auguet , Jeremiah Harnett
IPC分类号： A61K31395
CPC分类号： C07D417/12 , C07D333/38 , C07D409/12
摘要： A method for treating neurodegenerative diseases in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula wherein A selected from the group consisting of hydrogen and wherein the substituents are defined as set forth in the specification.
摘要翻译： 一种用于治疗温血动物中的神经退行性疾病的方法，其包括向有需要的温血动物施用一定数量的选自氢并且其中所述取代基的选择性化合物的化合物定义如说明书 。
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24.发明授权Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them 失效N-（亚氨基甲基）胺的衍生物，它们的制备，它们作为药物的用途以及含有它们的药物组合物公开(公告)号：US06620840B1
公开(公告)日：2003-09-16
申请号：US10255849
申请日：2002-09-26
申请人： Dennis Bigg , Pierre-Etienne Chabrier de Lassauniere , Serge Auvin , Jeremiah Harnett , Gérard Ulibarri
发明人： Dennis Bigg , Pierre-Etienne Chabrier de Lassauniere , Serge Auvin , Jeremiah Harnett , Gérard Ulibarri
IPC分类号： A61K3138
CPC分类号： C07D333/38
摘要： N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.
摘要翻译： N-（亚氨基）胺及其制备及其作为NO合酶抑制剂的用途以及用于活性氧的选择性或非选择性捕获。
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25.发明授权Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them 有权2-（亚氨基甲基）氨基 - 苯基的衍生物，它们的制备，它们作为药物的用途以及含有它们的药物组合物公开(公告)号：US06335445B1
公开(公告)日：2002-01-01
申请号：US09456205
申请日：1999-12-07
申请人： Pierre Etienne Chabrier de Lassauniere , Serge Auvin , Dennis Bigg , Michel Auguet , Jeremiah Harnett
发明人： Pierre Etienne Chabrier de Lassauniere , Serge Auvin , Dennis Bigg , Michel Auguet , Jeremiah Harnett
IPC分类号： C07D24104
CPC分类号： C07D417/12 , C07D333/38 , C07D409/12
摘要： A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of and the other substituents are defined in the specification having an inhibitory activity of NO-synthase enzymes producing nitrogen mono-oxide and/or an activity which traps the reactive oxygen species.
摘要翻译： 选自由下列组成的组的化合物选自由以下组成的组中，并且其它取代基在本说明书中定义，其具有产生氮一氧化物的NO合成酶和/或捕获的活性的抑制活性 活性氧。
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公开(公告)号：US20090018120A1
公开(公告)日：2009-01-15
申请号：US12090991
申请日：2006-10-18
IPC分类号： A61K31/5415 , C07D279/18 , A61P29/00 , A61P37/00 , A61P9/00 , A61P25/00 , A61P19/10 , A61P35/00 , A61P31/12
CPC分类号： C07D417/12 , C07D279/16 , C07D279/20
摘要： The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.
摘要翻译： 本发明涉及显示钙激素抑制活性和/或氧反应形式捕获活性的通式（I）的脒衍生物。
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27.发明授权公开(公告)号：US07465721B2
公开(公告)日：2008-12-16
申请号：US10532731
申请日：2004-12-08
IPC分类号： C07D417/02 , A61K31/5415
CPC分类号： C07K5/1024 , A61K38/00 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06165 , C07K5/0821
摘要： A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive oxygen species useful for treating inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.
摘要翻译： 具有下式的羟基四氢呋喃其中A具有本说明书中所定义的取代基，具有钙蛋白酶抑制活性和/或捕获可用于治疗炎性和免疫疾病，心血管和脑血管疾病，病症的活性氧的活性 中枢或周围神经系统，骨质疏松症，肌营养不良症，增殖性疾病，白内障，器官移植后的排斥反应以及自身免疫性和病毒性疾病。
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28.发明申请Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them 有权2-（亚氨基甲基）氨基 - 苯基的衍生物，它们的制备，它们作为药物的用途以及含有它们的药物组合物公开(公告)号：US20080182993A1
公开(公告)日：2008-07-31
申请号：US12009742
申请日：2008-01-22
申请人： Pierre Etienne Chabrier De Lassauniere , Serge Auvin , Dennis Bigg , Michel Auquet , Jeremiah Harnett
发明人： Pierre Etienne Chabrier De Lassauniere , Serge Auvin , Dennis Bigg , Michel Auquet , Jeremiah Harnett
IPC分类号： C07D277/18
CPC分类号： C07D333/34 , C07D333/38 , C07D409/12 , C07D417/12
摘要： 4-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-N-methyl-2-thiazolemethanamine which is an intermediate.
摘要翻译： 作为中间体的4- [3,5-双（1,1-二甲基乙基）-4-羟基苯基] -N-甲基-2-噻唑甲胺。
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公开(公告)号：US07384933B2
公开(公告)日：2008-06-10
申请号：US11115480
申请日：2005-04-27
IPC分类号： C07D417/02 , A61K31/5415
CPC分类号： C07K5/1024 , A61K38/00 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06139 , C07K5/06165 , C07K5/0821
摘要： A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the reactive oxygen species useful for treating inflammatory and immunological diseases, cardio-vascular and cerebro-vascular diseases, disorders of the central or peripheral nervous system, osteoporosis, muscular dystrophy, proliferative diseases, cataract, rejection reactions following organ transplants and autoimmune and viral diseases.
摘要翻译： 具有下式的羟基四氢呋喃其中A具有本说明书中所定义的取代基，具有钙蛋白酶抑制活性和/或捕获可用于治疗炎性和免疫疾病，心血管和脑血管疾病，病症的活性氧的活性 中枢或周围神经系统，骨质疏松症，肌营养不良症，增殖性疾病，白内障，器官移植后的排斥反应以及自身免疫性和病毒性疾病。
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30.发明授权公开(公告)号：US07244711B2
公开(公告)日：2007-07-17
申请号：US10415638
申请日：2001-11-14
CPC分类号： A61K45/06 , A61K31/27 , A61K2300/00
摘要： The invention concerns a pharmaceutical composition comprising, as active principle, at least a calpain inhibiting substance and at least a substance trapping reactive oxygen species (ROS), and optionally an acceptable pharmaceutical carrier. The invention also concerns a product comprising at least a calpain inhibiting substance and at least a substance trapping reactive oxygen species (ROS), selectively or not, as combination product, the active principle being separate.
摘要翻译： 本发明涉及药物组合物，其包含作为活性成分的至少钙蛋白酶抑制物质和至少捕获活性氧（ROS）的物质和任选的可接受的药物载体。 本发明还涉及至少包含钙蛋白酶抑制物质和至少一种捕获活性氧（ROS）的物质作为组合产物的产品，活性成分是分开的。
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