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21.发明授权Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]-butyl)-1H-azole derivatives for the preparation of medicaments intended for the treatment of disorders of gastric secretion 失效1- [4- [4-芳基（或杂芳基）-1-哌嗪基] - 丁基）-1H-吡唑衍生物在制备用于治疗胃分泌紊乱的药物中的用途
公开(公告)号：US5532234A
公开(公告)日：1996-07-02
申请号：US344377
申请日：1994-11-23
IPC分类号： C07D249/08 , A61K31/495 , A61K31/505 , A61P1/04 , C07D207/325 , C07D231/16 , C07D233/68 , C07D403/12 , C07D417/12 , C07D471/04 , A61K31/54 , A61K31/535
CPC分类号： A61K31/505 , A61K31/495 , Y10S514/925
摘要： The present invention relates to the use of 1-{4-[4-aryl(or heteroaryl)-1-piperazinyl]butyl}-1H-azole derivatives and of their physiologically acceptable salts for the manufacture of medicaments intended for the treatment of disorders associated with gastric secretion.
摘要翻译： 本发明涉及1- {4- [4-芳基（或杂芳基）-1-哌嗪基]丁基} -1H-吡唑衍生物及其生理学上可接受的盐在制备用于治疗疾病的药物中的用途 与胃分泌相关。
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22.发明授权2-(4-azolylbutyl)-1-piperazinyl)-5-hydroxy-pyrimidine derivatives, their preparation and their application as medicinal products 失效2-（4-噻唑基丁基）-1-哌嗪基）-5-羟基 - 嘧啶衍生物，其制备及其作为药用物质的应用
公开(公告)号：US5444059A
公开(公告)日：1995-08-22
申请号：US192142
申请日：1994-02-04
IPC分类号： A61K31/505 , A61K31/506 , A61P25/00 , A61P25/20 , A61P25/22 , C07D239/28 , C07D239/42 , C07D403/12 , C07D403/14 , A61K31/495
CPC分类号： C07D403/12
摘要： 2-[4-(4-azolylbutyl)-1-piperazinyl]-pyrimidine derivatives characterized in that they correspond to the general formula I ##STR1## in which X.sub.2 represents a nitrogen atom or a C-R.sub.2 group, X.sub.4 represents a nitrogen atom or a C-R.sub.4 group, X.sub.5 represents a nitrogen atom or a C-R.sub.5 group, the process for preparing them, their application as medicinal product, and the pharmaceutical compositions containing them.
摘要翻译： 2- [4-（4-氮杂丁基）-1-哌嗪基] - 嘧啶衍生物，其特征在于它们对应于其中X 2表示氮原子或C-R 2基团的通式I I，其中X 4表示氮 原子或C-R 4基团，X 5表示氮原子或C-R 5基团，其制备方法，其作为药用产品的应用，以及含有它们的药物组合物。
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23.发明授权Substituted tetrahydro-quinoline-sulfonamide compounds, their preparation and use as medicaments 失效取代的四氢 - 喹啉 - 磺酰胺化合物，其制备和用作药物公开(公告)号：US07964603B2
公开(公告)日：2011-06-21
申请号：US12175660
申请日：2008-07-18
IPC分类号： A61K31/496 , C07D215/58
CPC分类号： A61K31/4709 , C07D215/38 , C07D215/58
摘要： The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.
摘要翻译： 本发明涉及通式（I）的取代的四氢 - 喹啉 - 磺酰胺化合物：其制备方法，包含这些化合物的药物以及取代的四氢 - 喹啉 - 磺酰胺化合物用于制备5-HT6的药物 受体调节以及与之相关的疾病的治疗。
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24.发明申请SUBSTITUTED TETRAHYDRO-QUINOLINE-SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS 失效取代的四氢喹啉磺酰胺化合物，其制备和用作药物公开(公告)号：US20090030013A1
公开(公告)日：2009-01-29
申请号：US12175660
申请日：2008-07-18
IPC分类号： A61K31/496 , C07D401/02 , A61P3/00 , A61P25/00
CPC分类号： A61K31/4709 , C07D215/38 , C07D215/58
摘要： The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.
摘要翻译： 本发明涉及通式（I）的取代的四氢 - 喹啉 - 磺酰胺化合物：其制备方法，包含这些化合物的药物以及取代的四氢 - 喹啉 - 磺酰胺化合物用于制备5-HT6的药物 受体调节以及与之相关的疾病的治疗。
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25.发明申请公开(公告)号：US20080280942A1
公开(公告)日：2008-11-13
申请号：US11997136
申请日：2006-07-26
IPC分类号： A61K31/437 , C07D471/14 , A61P3/00 , A61P25/22 , A61P25/28 , A61P25/18
CPC分类号： C07D471/04
摘要： The present invention relates to new tetrahydro-β-carbolin-sulfonamide derivatives of general formula (I), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemates or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or corresponding physiologically acceptable salts or corresponding solvates. These compounds are suitable as pharmacologically active agents in a medicament for the prophylaxis and/or treatment of disorders or diseases related to 5-HT6 receptors. The invention also relates to two different methods for obtaining the mentioned compounds and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及通式（I）的新的四氢-β-咔啉 - 磺酰胺衍生物，任选地以其立体异构体之一的形式，优选对映异构体或非对映异构体，其外消旋体或其至少两种立体异构体的混合物的形式 ，优选对映异构体或非对映体，以任何混合比例，或相应的生理上可接受的盐或相应的溶剂化物。 这些化合物在用于预防和/或治疗与5-HT 6受体相关的疾病或疾病的药物中适合作为药理学活性剂。 本发明还涉及获得所述化合物和含有它们的药物组合物的两种不同方法。
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