公开(公告)号：US20090228245A1

公开(公告)日：2009-09-10

申请号：US11913098

申请日：2006-07-28

申请人： Kenneth H. Gilbert ,  John Douglas Birdwell ,  Tse-Wei Wang ,  Dale V. Stransberry

发明人： Kenneth H. Gilbert ,  John Douglas Birdwell ,  Tse-Wei Wang ,  Dale V. Stransberry

IPC分类号： G06F19/00

CPC分类号： G01N30/8624

摘要： Analysis of DNA is critical to many applications including identifying perpetrators of crimes based on genetic evidence left at crime scenes. An initial step to analyzing DNA data is detection, identification, and quantization of allele peaks in the DNA data. The invention provides a method and apparatus for accurately and expeditiously performing this initial step by sequentially checking unfitted peaks against various models including a default model, a hybrid peak model, a dual fit model and, in special situations, a narrow fit function and a saturated fit function.

摘要翻译： DNA分析对许多应用至关重要，包括根据犯罪现场留下的遗传证据确定犯罪者。 分析DNA数据的初步步骤是DNA数据中等位基因峰的检测，鉴定和量化。 本发明提供了一种方法和装置，用于通过对包括默认模型，混合峰值模型，双拟合模型在内的各种模型顺序检查未匹配的峰值来准确且快速地执行该初始步骤，并且在特殊情况下，窄拟合函数和饱和 适合功能。

公开(公告)号：US08140271B2

公开(公告)日：2012-03-20

申请号：US12947063

申请日：2010-11-16

申请人： Tse-Wei Wang ,  John Douglas Birdwell ,  Xue Ning ,  Mark S. Rader ,  John Flaherty

发明人： Tse-Wei Wang ,  John Douglas Birdwell ,  Xue Ning ,  Mark S. Rader ,  John Flaherty

IPC分类号： G06F7/00

CPC分类号： G06F19/18 ,  G06F19/22 ,  G06F19/24 ,  Y10S707/99943

摘要： Least Square Deconvolution (LSD) uses quantitative allele peak data, for example, allele peak area, allele peak height and optical density, derived/obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit of the mass ratio coefficients at each locus to come closest to the quantitative allele peak data. Consistent top-ranked mass ratio combinations from each locus can be pooled to form at least one composite DNA profile at a subset of the available loci. The top-ranked DNA profiles can be used to check against the profile of a suspect or be used to search for a matching profile in a DNA database.

摘要翻译： 最小二乘解卷积（LSD）使用定量等位基因峰数据，例如从包含多于一个贡献者的DNA的样品得到/获得的等位基因峰面积，等位基因峰高度和光密度，以解决每一个的最佳拟合基因型谱 贡献者。 该分辨率基于找到每个轨迹处的质量比系数的最小二乘拟合最接近定量等位基因峰数据。 可以汇集来自每个基因座的一致的顶级质量比组合，以在可用基因座的子集处形成至少一个复合DNA谱。 排名最高的DNA谱可用于检查疑似病例的轮廓，或用于在DNA数据库中搜索匹配的分布。

公开(公告)号：US09414776B2

公开(公告)日：2016-08-16

申请号：US13787406

申请日：2013-03-06

申请人： Karl Arthur Sillay ,  John Douglas Birdwell

发明人： Karl Arthur Sillay ,  John Douglas Birdwell

IPC分类号： A61B5/00 ,  G06F19/00 ,  A61B5/145 ,  A61B5/11 ,  A61N1/36 ,  A61B5/0205 ,  A61B5/01 ,  A61B5/06 ,  A61N1/372

CPC分类号： A61B5/4082 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/064 ,  A61B5/11 ,  A61B5/1101 ,  A61B5/14542 ,  A61B5/4842 ,  A61B34/20 ,  A61B2034/2065 ,  A61M5/142 ,  A61M25/007 ,  A61M2210/0687 ,  A61N1/3605 ,  A61N1/36067 ,  A61N1/37282 ,  G06F19/00 ,  G06F19/321 ,  G06F19/325 ,  G16H10/20 ,  G16H50/70 ,  H04L63/10

摘要： A suite of components comprising an objective measurement medical data collection device and a cohort database may standardize, simplify, and objectify clinical outcomes tracking, culminating in population health measurements within the restorative neurosciences such as Parkinson disease individuals diagnosed with a disease. A data collection device may comprise one or more of a gyroscope, an accelerometer, a locator, a camera and a magnetometer for collecting, for example, data related to tremors experienced by the individuals diagnosed with disease and receive instruction data responsive to evaluation of the collected data in relation to the cohort database. A related method collects objective measurements during phases of treatment such as preoperative symptomatology, probabilistic atlas linked targeting for neuromodulation, accountancy for gravitational effects of brain shift during surgery, measurements of movement and quality of life during supervised treatment and ongoing community and self-directed treatment and provides feedback to implants, intelligent devices and users thereof.

摘要翻译： 包括客观测量医疗数据收集装置和队列数据库的组件套件可以标准化，简化和客观化临床结果跟踪，最终导致恢复性神经科学中的群体健康测量，例如诊断为疾病的帕金森病患者。 数据收集装置可以包括陀螺仪，加速度计，定位器，照相机和磁力计中的一个或多个，用于收集例如与诊断患有疾病的个体经历的震颤相关的数据，以及接收指令数据， 收集与群组数据库相关的数据。 相关方法在治疗阶段收集客观测量结果，例如术前症状学，概率图谱联合靶向神经调节，术前脑移位重力影响的计量，监督治疗期间运动和生活质量的测量以及正在进行的社区和自我定向治疗 并为植入物，智能设备及其用户提供反馈。