公开(公告)号：US08338424B2

公开(公告)日：2012-12-25

申请号：US13468200

申请日：2012-05-10

Applicant: YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

Inventor： YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

IPC: A61K31/496

CPC classification number: C07D333/24 ,  C07D209/14 ,  C07D213/38 ,  C07D231/12 ,  C07D277/28 ,  C07D295/13 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/58

Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US08198304B2

公开(公告)日：2012-06-12

申请号：US13228782

申请日：2011-09-09

Applicant: YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

Inventor： YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

IPC: A61K31/4525 ,  A61K31/453 ,  A61K31/4535 ,  A61K31/445 ,  C07D213/68 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D333/24 ,  C07D209/14 ,  C07D213/38 ,  C07D231/12 ,  C07D277/28 ,  C07D295/13 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/58

Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中R1-3，R5-7，a，X，Y，Y'，Y“和Z如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

公开(公告)号：US20110319448A1

公开(公告)日：2011-12-29

申请号：US13228782

申请日：2011-09-09

Applicant: YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

Inventor： YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

IPC: A61K31/4535 ,  C07D295/15 ,  C07D401/12 ,  C07D417/12 ,  C07D403/12 ,  A61P11/08 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/4525 ,  A61P11/00 ,  A61P11/06 ,  C07D409/12 ,  C07D405/12

CPC classification number: C07D333/24 ,  C07D209/14 ,  C07D213/38 ,  C07D231/12 ,  C07D277/28 ,  C07D295/13 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/58

Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中R1-3，R5-7，a，X，Y，Y'，Y“和Z如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

公开(公告)号：US07975839B1

公开(公告)日：2011-07-12

申请号：US12584315

申请日：2009-09-03

Applicant: Rick Lee

Inventor： Rick Lee

IPC: B65G21/16

CPC classification number: B65G15/02 ,  B65G15/56

Abstract: The present invention is related to interlockers or beadings that are attached to the outer edges of conveyor belts. Interlockers and/or beadings or portions thereof are reinforced with aramid fibers to improve their durability.

Abstract translation: 本发明涉及连接到输送带的外边缘的互锁器或滚珠。 用芳族聚酰胺纤维增强交联剂和/或珠粒或其部分，以提高其耐久性。

公开(公告)号：US20090069335A1

公开(公告)日：2009-03-12

申请号：US12231861

申请日：2008-09-05

Applicant: YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

Inventor： YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

IPC: A61K31/496 ,  C07D241/04 ,  A61K31/495 ,  C07D207/02 ,  A61K31/40 ,  C07D211/06 ,  A61K31/444 ,  C07D409/02 ,  A61K31/4535 ,  C07D405/02 ,  A61K31/4525 ,  A61P11/00

CPC classification number: C07D333/24 ,  C07D209/14 ,  C07D213/38 ,  C07D231/12 ,  C07D277/28 ,  C07D295/13 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/58

Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中R1-3，R5-7，a，X，Y，Y'，Y“和Z如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

公开(公告)号：US20080207736A1

公开(公告)日：2008-08-28

申请号：US12070780

申请日：2008-02-21

Applicant: YuHua Ji ,  Craig Husfeld ,  Christopher Lange ,  Rick Lee ,  YongQi Mu

Inventor： YuHua Ji ,  Craig Husfeld ,  Christopher Lange ,  Rick Lee ,  YongQi Mu

IPC: A61K31/40 ,  A61P11/00 ,  C07D207/04

CPC classification number: C07D207/09 ,  C07D207/08 ,  C07D207/48

Abstract: The invention provides compounds of formula I: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a-e and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物：盐或两性离子形式或其药学上可接受的盐，其中R 1-6，a-e和Q如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

公开(公告)号：US08785633B2

公开(公告)日：2014-07-22

申请号：US13681794

申请日：2012-11-20

Applicant: YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

Inventor： YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

IPC: C07D307/54 ,  C07D333/24

CPC classification number: C07D333/24 ,  C07D209/14 ,  C07D213/38 ,  C07D231/12 ,  C07D277/28 ,  C07D295/13 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/58

Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中R1-3，R5-7，a，X，Y，Y'，Y“和Z如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

公开(公告)号：US08378121B2

公开(公告)日：2013-02-19

申请号：US12898861

申请日：2010-10-06

Applicant: YuHua Ji ,  Craig Husfeld ,  Christopher Lange ,  Rick Lee ,  YongQi Mu

Inventor： YuHua Ji ,  Craig Husfeld ,  Christopher Lange ,  Rick Lee ,  YongQi Mu

IPC: C07D211/70 ,  C07D207/08

CPC classification number: C07D207/09 ,  C07D207/08 ,  C07D207/48

Abstract: The invention provides compounds of formula I: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a-e and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US20120232053A1

公开(公告)日：2012-09-13

申请号：US13473792

申请日：2012-05-17

Applicant: Craig Husfeld ,  YuHua Ji ,  Rick Lee ,  Li Li ,  YongQi Mu ,  Cameron Smith ,  Johnny Uy

Inventor： Craig Husfeld ,  YuHua Ji ,  Rick Lee ,  Li Li ,  YongQi Mu ,  Cameron Smith ,  Johnny Uy

IPC: A61K31/4535 ,  A61K31/4468 ,  C07D401/12 ,  A61K31/454 ,  A61P11/06 ,  C07D405/12 ,  A61K31/453 ,  C07D205/04 ,  A61K31/397 ,  A61P11/00 ,  C07D211/58 ,  C07D409/12

CPC classification number: C07D409/14 ,  C07D205/04 ,  C07D211/26 ,  C07D211/58 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12

Abstract: The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供下式的化合物：盐或两性离子形式或其药学上可接受的盐，其中R1-6，a，Z和Q如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

公开(公告)号：US20120219509A1

公开(公告)日：2012-08-30

申请号：US13468200

申请日：2012-05-10

Applicant: YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

Inventor： YuHua Ji ,  Craig Husfeld ,  YongQi Mu ,  Rick Lee ,  Li Li

IPC: A61K31/496 ,  A61K9/12 ,  A61P11/08 ,  A61K31/58 ,  A61P29/00 ,  A61P11/00 ,  A61K31/56 ,  A61K31/573

CPC classification number: C07D333/24 ,  C07D209/14 ,  C07D213/38 ,  C07D231/12 ,  C07D277/28 ,  C07D295/13 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/58

Abstract: The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其中R1-3，R5-7，a，X，Y，Y'，Y“和Z如说明书中所定义。 这些化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。