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公开(公告)号：US08170682B2
公开(公告)日：2012-05-01
申请号：US11927391
申请日：2007-10-29
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译： 本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。 本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。 本公开中提出的装置包括能够执行所公开的方法的电路和系统。
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公开(公告)号：US09974953B2
公开(公告)日：2018-05-22
申请号：US13430356
申请日：2012-03-26
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： An apparatus for controlling the stimulation of neural tissue which includes a neural stimulator, an input device for providing input to the neural stimulator for neural stimulation, at least one electrode electrically connected to and driven by the neural stimulator and suitable to stimulate neural tissue, a device capable of determining a charge per phase by calculating a discrete integral of the wave form of the input for the at least one electrode, a calculating device for comparing the charge per phase to a predetermined maximum and determining a reduced stimulation for the at least one electrode by the amount necessary not to exceed the predetermined maximum for the at least one electrode, and a current pulse generator for stimulating the neural tissue according to the reduced stimulation level.
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公开(公告)号：US09913985B2
公开(公告)日：2018-03-13
申请号：US11413771
申请日：2006-04-28
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.
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公开(公告)号：US20120185015A1
公开(公告)日：2012-07-19
申请号：US13430356
申请日：2012-03-26
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译： 本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。 本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。 本公开中提出的装置包括能够执行所公开的方法的电路和系统。
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公开(公告)号：US08060216B2
公开(公告)日：2011-11-15
申请号：US11796433
申请日：2007-04-27
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： Electronic neural tissue stimulators for controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译： 用于控制电刺激水平的电子神经组织刺激器，以防止损伤神经组织。 本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。 本公开中提出的装置包括能够执行所公开的方法的电路和系统。
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公开(公告)号：US20080177356A1
公开(公告)日：2008-07-24
申请号：US11927391
申请日：2007-10-29
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/08
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译： 本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。 本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。 本公开中提出的装置包括能够执行所公开的方法的电路和系统。
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公开(公告)号：US08527062B2
公开(公告)日：2013-09-03
申请号：US12416824
申请日：2009-04-01
申请人： Rongqing Dai , Robert J. Greenberg
发明人： Rongqing Dai , Robert J. Greenberg
IPC分类号： A61N1/08
CPC分类号： A61N1/378 , A61N1/36046
摘要： A power scheme for an implant on a human or animal body comprises: a charging circuit to provide power to deliver controlled stimulation currents to a body tissue; a capacitive storage arrangement connected with the charging circuit and charged by the charging circuit; a shunting arrangement to limit voltage on the capacitive storage arrangement; a driver array configured to transfer charges from the capacitive storage arrangement to the tissue; and an electrode array connected with the driver array and the tissue.
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公开(公告)号：US08010206B2
公开(公告)日：2011-08-30
申请号：US11924423
申请日：2007-10-25
申请人： Rongqing Dai , Dao Min Zhou , Robert J. Greenberg , John Gord
发明人： Rongqing Dai , Dao Min Zhou , Robert J. Greenberg , John Gord
IPC分类号： A61N1/378
CPC分类号： A61N1/37229 , A61N1/36046 , A61N1/3787
摘要： Methods and devices for inductively coupled implants on the human or animal body are disclosed. An external coil assembly to be used with the implant has a transmitting coil and one or more receiving coils. The number of the receiving coils, their distance from the transmitting coil and their shape is chosen to reduce the influence of a noise signal received by the external coil assembly.
摘要翻译： 公开了用于人体或动物体上的电感耦合植入物的方法和装置。 与植入物一起使用的外部线圈组件具有发射线圈和一个或多个接收线圈。 选择接收线圈的数量，它们与发射线圈的距离及其形状，以减少由外部线圈组件接收的噪声信号的影响。
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公开(公告)号：US20080082143A1
公开(公告)日：2008-04-03
申请号：US11529809
申请日：2006-09-29
申请人： Rongqing Dai , Dao Min Zhou , Robert J. Greenberg , John Gord
发明人： Rongqing Dai , Dao Min Zhou , Robert J. Greenberg , John Gord
IPC分类号： A61N1/00
CPC分类号： A61N1/37229 , A61N1/36046 , A61N1/3787
摘要： Methods and devices for inductively coupled implants on the human or animal body are disclosed. An external coil assembly to be used with the implant has a transmitting coil and one or more receiving coils. The number of the receiving coils, their distance from the transmitting coil and their shape is chosen to reduce the influence of a noise signal received by the external coil assembly.
摘要翻译： 公开了用于人体或动物体上的电感耦合植入物的方法和装置。 与植入物一起使用的外部线圈组件具有发射线圈和一个或多个接收线圈。 选择接收线圈的数量，它们与发射线圈的距离及其形状，以减少由外部线圈组件接收的噪声信号的影响。
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公开(公告)号：US10065036B2
公开(公告)日：2018-09-04
申请号：US11906167
申请日：2007-09-28
摘要： The present invention is a method for measuring stable and reproducible electrode-tissue impedance, comprising preconditioning an electrode-tissue interface. Further aspect of the invention is a stimulation system for a visual prosthesis generating a stimulation signal to precondition the electrode-tissue interface, comprising a computer; software, loaded in the computer, adapted to perform a stimulating method for a visual prosthesis having a plurality of electrodes; a video processing unit; and an implanted neuron-stimulator.
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