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    Flexible circuit electrode array
    2.
    发明授权
    Flexible circuit electrode array 有权
    柔性电路电极阵列

    公开(公告)号：US08639344B2

    公开(公告)日：2014-01-28

    申请号：US11413689

    申请日：2006-04-28

    Applicant: Robert Jay Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  James Singleton Little ,  Brian V. Mech ,  Mark Humayun ,  Dilek Guven ,  Anne-Marie de Merlier Ripley

    Inventor： Robert Jay Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  James Singleton Little ,  Brian V. Mech ,  Mark Humayun ,  Dilek Guven ,  Anne-Marie de Merlier Ripley

    IPC: A61N1/05

    CPC classification number: H05K3/0011 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36036 ,  A61N1/36046 ,  Y10T29/49124

    Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

    Abstract translation: 聚合物材料可用作神经刺激的电极阵列体。 它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。 通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。 由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。 此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。 通过将适量的热应用于完整的阵列，可以引起曲线。 对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。 此外，沿着边缘添加材料是有利的。 在柔性电路阵列中提供折叠或扭曲是更有利的。 可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

    Electrode array for even neural pressure
    3.
    发明授权
    Electrode array for even neural pressure 有权
    电极阵列甚至神经压力

    公开(公告)号：US08588937B2

    公开(公告)日：2013-11-19

    申请号：US13360491

    申请日：2012-01-27

    Applicant: Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Jordan Matthew Neysmith

    Inventor： Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Jordan Matthew Neysmith

    IPC: A61N1/00

    CPC classification number: A61N1/0543 ,  A61N1/0558

    Abstract: An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention a central attachment point in the electrode field applies the most even pressure. Further, multiple and selective attachment points may be additionally provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.

    Abstract translation: 附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。 更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。 因此，有利的是在阵列场上获得相等的压力。 在本发明中，电极领域中的中心附着点施加最均匀的压力。 此外，可以在电极阵列上额外提供多个和选择性附着点，允许外科医生选择提供最佳电极组织接触的附接点。

    Electrode Array for Even Neural Pressure
    6.
    发明申请
    Electrode Array for Even Neural Pressure 有权
    用于均匀神经压力的电极阵列

    公开(公告)号：US20130030508A1

    公开(公告)日：2013-01-31

    申请号：US13360491

    申请日：2012-01-27

    Applicant: Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Jordan Matthew Neysmith

    Inventor： Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Jordan Matthew Neysmith

    IPC: A61N1/05

    CPC classification number: A61N1/0543 ,  A61N1/0558

    Abstract: An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention a central attachment point in the electrode field applies the most even pressure. Further, multiple and selective attachment points may be additionally provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.

    Abstract translation: 附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。 更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。 因此，有利的是在阵列场上获得相等的压力。 在本发明中，电极领域中的中心附着点施加最均匀的压力。 此外，可以在电极阵列上额外提供多个和选择性附着点，允许外科医生选择提供最佳电极组织接触的附接点。

    Electrode Array for Even Neural Pressure
    9.
    发明申请
    Electrode Array for Even Neural Pressure 有权
    用于均匀神经压力的电极阵列

    公开(公告)号：US20110144731A1

    公开(公告)日：2011-06-16

    申请号：US13029955

    申请日：2011-02-17

    Applicant: Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Jordan Matthew Neysmith

    Inventor： Robert J. Greenberg ,  Mark S. Humayun ,  James Singleton Little ,  Jordan Matthew Neysmith

    IPC: A61N1/05

    CPC classification number: A61N1/0543 ,  A61N1/0558

    Abstract: An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention multiple and selective attachment points are provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.

    Abstract translation: 附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。 更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。 因此，有利的是在阵列场上获得相等的压力。 在本发明中，在电极阵列上提供多个选择性附着点，允许外科医生选择提供最佳电极组织接触的附着点。

    Process for Cathodic Protection of Electrode Material
    10.
    发明申请
    Process for Cathodic Protection of Electrode Material 有权
    电极材料阴极保护工艺

    公开(公告)号：US20100147702A1

    公开(公告)日：2010-06-17

    申请号：US12708358

    申请日：2010-02-18

    Applicant: Dao Min Zhou ,  Amy Hines ,  James Singleton Little ,  Robert J. Greenberg

    Inventor： Dao Min Zhou ,  Amy Hines ,  James Singleton Little ,  Robert J. Greenberg

    IPC: C23F13/00

    CPC classification number: C23F13/00 ,  A61N1/05 ,  A61N1/08 ,  C23F13/02

    Abstract: The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode. The negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.

    Abstract translation: 本发明涉及对电极或电极材料进行阴极保护的方法，其中负电极施加在电极上。 负偏压通过不对称电流脉冲获得。 通过执行具有较高振幅的负相来获得非对称电流脉冲。 通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。 通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。 本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相 脉冲宽度大于阳极相。 通过脉冲串获得更宽的脉冲宽度。

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