公开(公告)号：US10137303B2

公开(公告)日：2018-11-27

申请号：US13473470

申请日：2012-05-16

申请人： Robert J Greenberg ,  David Daomin Zhou ,  Brian V Mech ,  Neil Hamilton Talbot ,  Rongqing Dai ,  Richard Agustin Castro ,  Kelly H. McClure

发明人： Robert J Greenberg ,  David Daomin Zhou ,  Brian V Mech ,  Neil Hamilton Talbot ,  Rongqing Dai ,  Richard Agustin Castro ,  Kelly H. McClure

IPC分类号： A61B5/04 ,  A61N1/00 ,  A61N1/36 ,  A61B5/00 ,  A61N1/05 ,  A61N1/375 ,  H05K1/11 ,  H05K1/18

摘要： The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. The output signals provide control for a motor prosthesis and the inputs signals provide sensory feedback for the motor prosthesis. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

公开(公告)号：US10065036B2

公开(公告)日：2018-09-04

申请号：US11906167

申请日：2007-09-28

申请人： Amy Chu Peishuan Hines ,  Dao Min Zhou ,  Arup Roy ,  Rongqing Dai ,  Robert J. Greenberg

发明人： Amy Chu Peishuan Hines ,  Dao Min Zhou ,  Arup Roy ,  Rongqing Dai ,  Robert J. Greenberg

IPC分类号： A61N1/36 ,  A61N1/05

摘要： The present invention is a method for measuring stable and reproducible electrode-tissue impedance, comprising preconditioning an electrode-tissue interface. Further aspect of the invention is a stimulation system for a visual prosthesis generating a stimulation signal to precondition the electrode-tissue interface, comprising a computer; software, loaded in the computer, adapted to perform a stimulating method for a visual prosthesis having a plurality of electrodes; a video processing unit; and an implanted neuron-stimulator.

公开(公告)号：US09943688B2

公开(公告)日：2018-04-17

申请号：US13163506

申请日：2011-06-17

申请人： Richard Agustin Castro ,  Robert J. Greenberg

发明人： Richard Agustin Castro ,  Robert J. Greenberg

IPC分类号： A61F9/08 ,  A61N1/36 ,  G01R33/48 ,  A61N1/08

CPC分类号： A61N1/36046 ,  A61N1/086 ,  G01R33/4806

摘要： The present invention is wireless visual prosthesis with a remote driver for the external coils this, among other things, provides for a magnetic resonance image (MRI) safe visual prosthesis. fMRI is an effective tool for analyzing cortical responses to neural stimulation, such as from a visual prosthesis. However, the external electronics of a visual prosthesis cannot operate in a MRI field. The present invention provides a radio frequency shielded link between a video processing unit, driver circuitry and the coils used for communicating with the implantable portion of the visual prosthesis.

公开(公告)号：US09643002B2

公开(公告)日：2017-05-09

申请号：US13167074

申请日：2011-06-23

申请人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  James Singleton Little ,  Brian V. Mech

发明人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  James Singleton Little ,  Brian V. Mech

IPC分类号： A61N1/05 ,  A61N1/36 ,  H05K1/11 ,  H05K3/00

CPC分类号： A61N1/0543 ,  A61N1/36046 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/0014 ,  H05K2201/05 ,  H05K2201/053 ,  H05K2201/09063 ,  H05K2201/09409 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

摘要： The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on the polymer base layer and the metal traces at least one tack opening. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on the polymer base layer; patterning the metal to form metal traces; depositing a polymer top layer on the polymer base layer and the metal traces; and preparing at least one tack opening.

公开(公告)号：US09592377B2

公开(公告)日：2017-03-14

申请号：US12180436

申请日：2008-07-25

申请人： Robert J. Greenberg ,  Brian V. Mech ,  Kelly H. McClure

发明人： Robert J. Greenberg ,  Brian V. Mech ,  Kelly H. McClure

IPC分类号： A61N1/00 ,  A61N1/05 ,  A61N1/36 ,  A61N1/375 ,  H05K1/14 ,  H05K3/28

CPC分类号： A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36082 ,  A61N1/37229 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H05K1/028 ,  H05K1/111 ,  H05K1/141 ,  H05K1/147 ,  H05K3/284

摘要： The present invention consists of an implantable device with at least one package that houses electronics that receives input data or signals, and optionally power, from an external system through at least one coil attached to the at least one package, processes the input data and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

摘要翻译： 本发明包括具有至少一个封装的可植入装置，所述至少一个封装容纳电子装置，所述电子装置通过连接到所述至少一个封装件的至少一个线圈从外部系统接收输入数据或信号以及可选地供电，处理所述输入数据并传送 通过至少一个连接到至少一个封装的多个电极阵列的电脉冲到神经组织。 本发明或其组分旨在安装在头部，或在头颅或硬脑膜上，或脑中或脑中。

公开(公告)号：US09381354B2

公开(公告)日：2016-07-05

申请号：US13571244

申请日：2012-08-09

申请人： Arup Roy ,  Sanjay Gaikwad ,  Kelly H. McClure ,  Timothy M. Nugent ,  Robert J. Greenberg

发明人： Arup Roy ,  Sanjay Gaikwad ,  Kelly H. McClure ,  Timothy M. Nugent ,  Robert J. Greenberg

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/37223

摘要： The present invention is a new configuration for the external portion of a visual prosthesis in the form of a visor or glasses, including a frame supported by a user's nose and ears. The video processing unit is adapted to be connected by temple portions of the visor and rest on the user's upper back behind the user's neck, or behind the user's head. Controls for the video processor are on one or both temple portions of the visor.

摘要翻译： 本发明是一种以遮阳板或眼镜形式的视觉假体的外部部分的新结构，其包括由使用者的鼻子和耳朵支撑的框架。 视频处理单元适于通过遮阳板的镜腿部分连接，并且放置在用户的脖子后面或用户头部后面的用户的上背部上。 视频处理器的控件位于遮阳板的一个或两个镜腿部分。

公开(公告)号：US09295581B2

公开(公告)日：2016-03-29

申请号：US11352168

申请日：2006-02-13

申请人： James S. Little ,  Gaillard R. Nolan ,  Neil H. Talbot ,  Robert J. Greenberg

发明人： James S. Little ,  Gaillard R. Nolan ,  Neil H. Talbot ,  Robert J. Greenberg

IPC分类号： A61F2/16 ,  A61F9/007 ,  A61B17/064 ,  A61B17/068 ,  A61F11/00 ,  A61B17/10

CPC分类号： A61F9/00727 ,  A61B17/064 ,  A61B17/068 ,  A61B17/10 ,  A61B2017/0646 ,  A61B2017/0647 ,  A61F9/007 ,  A61F11/004

摘要： The present invention is an improved medical tack. The tack of the present invention includes attachment points at each end where at least one of the attachment points is moveable, varying the effective length of the tack. Varying the length of the medical tack adapts the tack for use with tissue of different thickness.

公开(公告)号：US09205257B1

公开(公告)日：2015-12-08

申请号：US13481425

申请日：2012-05-25

申请人： Brian Coley ,  Francesco Merlini ,  Robert J. Greenberg

发明人： Brian Coley ,  Francesco Merlini ,  Robert J. Greenberg

IPC分类号： A61N1/32 ,  A61N1/36 ,  A61F2/14

CPC分类号： A61N1/36046 ,  A61F2/141 ,  A61F2/145 ,  A61N1/0543

摘要： The present invention is an improved method of electrically stimulating percepts in a patient with a visual prosthesis, to induce the perception of color. In particular, the present invention is a method of inducing the perception of color by determining experimentally which patterns induce which colors, storing that information and using the stored information to induce the perception of color according to video input data and the stored color information.

摘要翻译： 本发明是用视觉假体电刺激患者感知的改进方法，以诱导颜色的感知。 特别地，本发明是通过实验确定诱导颜色的感知的方法，其中哪些图案根据视频输入数据和所存储的颜色信息来诱导哪种颜色，存储该信息并使用所存储的信息来诱导颜色的感知。

公开(公告)号：US08738149B2

公开(公告)日：2014-05-27

申请号：US13397604

申请日：2012-02-15

申请人： Qingfang Yao ,  Jordan Matthew Nevsmith ,  Neil Hamilton Talbot ,  James Singleton Little ,  Robert J. Greenberg

发明人： Qingfang Yao ,  Jordan Matthew Nevsmith ,  Neil Hamilton Talbot ,  James Singleton Little ,  Robert J. Greenberg

IPC分类号： A61N1/04

CPC分类号： A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  B23K26/361 ,  B23K26/362

摘要： The invention involves a flexible circuit electrode array device comprising: a polymer layer; wherein the polymer layer includes one or more metal traces, an electrode array; one or more bond pads; and the electrode array is located on the opposite side of the polymer layer.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: applying polymer film on a substrate; processing the front side; releasing the polymer film from substrate; flipping over the polymer film and fixing it onto the substrate; processing the backside; and final releasing of the polymer film from the substrate.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: processing the front side without releasing the polymer; processing the backside by sacrificial substrate method, or by laser drilling method; and releasing the polymer film from the substrate.

摘要翻译： 本发明涉及一种柔性电路电极阵列器件，包括：聚合物层; 其中所述聚合物层包括一个或多个金属迹线，电极阵列; 一个或多个接合垫; 并且电极阵列位于聚合物层的相对侧上。 本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：在基底上施加聚合物膜; 正面加工; 从基材中释放聚合物膜; 翻转在聚合物膜上并将其固定在基底上; 处理背面; 并从基底中最终释放聚合物膜。 本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：处理前侧而不释放聚合物; 通过牺牲基板方法或通过激光钻孔方法处理背面; 并从基板上释放聚合物膜。

公开(公告)号：US08501547B2

公开(公告)日：2013-08-06

申请号：US13567366

申请日：2012-08-06

申请人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Honggang Jiang

发明人： Robert J. Greenberg ,  Neil Hamilton Talbot ,  Jordan Matthew Neysmith ,  Jerry Ok ,  Honggang Jiang

IPC分类号： H01L21/56

CPC分类号： A61N1/375 ,  A61N1/3754 ,  H01L23/291 ,  H01L23/3107 ,  H01L24/03 ,  H01L24/05 ,  H01L24/12 ,  H01L24/85 ,  H01L2224/0345 ,  H01L2224/0347 ,  H01L2224/0401 ,  H01L2224/05083 ,  H01L2224/05124 ,  H01L2224/05147 ,  H01L2224/05164 ,  H01L2224/05166 ,  H01L2224/05187 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2224/13099 ,  H01L2224/13164 ,  H01L2224/13169 ,  H01L2224/85 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01019 ,  H01L2924/01022 ,  H01L2924/01024 ,  H01L2924/01027 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01041 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/04941 ,  H01L2924/10253 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1433 ,  H01L2924/351 ,  H01L2924/04953 ,  H01L2924/00 ,  H01L2224/48 ,  H01L2224/45015 ,  H01L2924/207 ,  H01L2224/45099

摘要： An implantable hermetically sealed microelectronic device and method of manufacture are disclosed. The microelectronic device of the present invention is hermetically encased in a insulator, such as alumina formed by ion bean assisted deposition (“IBAD”), with a stack of biocompatible conductive layers extending from a contact pad on the device to an aperture in the hermetic layer. In a preferred embodiment, one or more patterned titanium layers are formed over the device contact pad, and one or more platinum layers are formed over the titanium layers, such that the top surface of the upper platinum layer defines an external, biocompatible electrical contact for the device. Preferably, the bottom conductive layer is larger than the contact pad on the device, and a layer in the stack defines a shoulder.

摘要翻译： 公开了可植入气密微电子器件及其制造方法。 本发明的微电子器件气密地封装在诸如由离子豆辅助沉积（“IBAD”）形成的氧化铝之类的绝缘体中，一堆生物相容的导电层从器件上的接触垫延伸到密封的孔 层。 在优选实施例中，在器件接触焊盘上形成一个或多个图案化的钛层，并且在钛层上形成一个或多个铂层，使得上铂层的顶表面限定外部的生物相容的电接触， 装置。 优选地，底部导电层大于器件上的接触焊盘，并且堆叠中的层限定了肩部。