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45 条记录 (耗时 0.024 秒)

    Pool coping protector
    23.
    发明授权
    Pool coping protector 失效
    水池应急保护

    公开(公告)号：US5421041A

    公开(公告)日：1995-06-06

    申请号：US105723

    申请日：1993-08-12

    申请人： Robert Stern

    发明人： Robert Stern

    IPC分类号： E04H4/10 ,  E04H4/14

    CPC分类号： E04H4/10 ,  Y10T24/44923

    摘要： A pool deck protector cooperative with the perimeter coping of the pool to prevent wear and discoloration to the pool deck and pool coping by the tie-down assembly securing the pool cover to a pool cover anchor. The pool deck protector is generally planar with one edge curved under upon the underside of the planar member, the curved edge having a decreasing radius such that it is frictionally engageable in a snap-fit manner with the perimeter coping of the pool to position the pool deck protector in alignment with the tie-down assembly thereby protecting the perimeter coping and immediate pool deck area.

    摘要翻译： 游泳池甲板保护者与周边应对游泳池相结合，以防止泳池甲板上的磨损和褪色，以及通过将游泳池盖固定到游泳池盖锚的系紧组件来处理池。 游泳池甲板保护器通常是平面的，其中一个边缘在平面构件的下侧下方弯曲，弯曲的边缘具有减小的半径，使得其能够以卡扣配合的方式与池的周边配对摩擦接合以定位池 甲板保护器与系紧组件对准，从而保护周边应对和立即池底面积。

    Method of treating tumor-bearing patients with human plasma hyaluronidase
    28.
    发明授权
    Method of treating tumor-bearing patients with human plasma hyaluronidase 失效
    用人血浆透明质酸酶处理肿瘤患者的方法

    公开(公告)号：US06193963B1

    公开(公告)日：2001-02-27

    申请号：US08916935

    申请日：1997-08-21

    申请人： Robert Stern ,  Gregory I. Frost ,  Anthony Csóka ,  Tim M. Wong

    发明人： Robert Stern ,  Gregory I. Frost ,  Anthony Csóka ,  Tim M. Wong

    IPC分类号： A61K3800

    CPC分类号： C12Y302/01035 ,  A61K38/00 ,  C07K16/40 ,  C12N9/16 ,  C12N9/2474 ,  C12Y302/01036 ,  G01N33/573

    摘要： The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21.3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.

    摘要翻译： 本发明基于发现用于纯化在人血浆（hpHA）中发现的酸活性透明质酸酶的方法，包括生物化学和免疫亲和纯化方法。 本发明的免疫亲和纯化方法基于发现用于鉴定特异性结合天然hpHA（抗天然hpHAse抗体）的抗体的方法，以及通过该筛选方法鉴定的抗天然hpHAse抗体。 本发明还特征在于使用生物素化透明质酸（bHA）敏感检测HAse活性的测定。 hpHAse的纯化和表征导致发明人进一步发现，hpHAse由LuCa-1基因编码，该基因存在于3p21.3的人染色体中，该肿瘤与肿瘤抑制有关。 本发明另外具有通过施用hpHA和/或用hpHA编码DNA转化细胞来治疗荷瘤患者的方法。

    Process for the production of ethyl esters
    29.
    发明授权
    Process for the production of ethyl esters 失效
    生产乙酯的方法

    公开(公告)号：US6013817A

    公开(公告)日：2000-01-11

    申请号：US852737

    申请日：1997-05-07

    申请人： Robert Stern ,  Gerard Hillion ,  Mohammed Neguib Eisa

    发明人： Robert Stern ,  Gerard Hillion ,  Mohammed Neguib Eisa

    IPC分类号： C07C67/03 ,  C11C3/04 ,  C11C3/10 ,  C07C51/00

    CPC分类号： C11C3/003 ,  C07C67/03 ,  C11C3/04 ,  C11C3/10

    摘要： For the production of ethyl esters of fatty acids from fatty acid glycerides such as vegetable or animal oil or fat or other mixtures of glycerides, the process comprises the following stages: (a) transesterifying fatty acid glycerides with hydrated ethyl alcohol using an alkaline catalyst to form a medium comprising ethyl esters and excess ethyl alcohol; (b) adding a glycerine phase to said medium, and evaporating the excess ethyl alcohol to produce two immiscible phases, an ester phase and a glycerine phase A, and recycling said excess ethyl alcohol to stage (a); (c) separating said glycerine phase A and said ester phase to obtain the desired ethyl esters; (d) neutralizing said glycerine phase A with acid, and separating resultant "fatty acids+esters" phase and a glycerine phase B, and drying the latter phase; (e) subjecting the "fatty acids+esters" phase to glycerolysis with at least a fraction of the dried glycerine phase B in the presence of an alkaline catalyst to form a mixture of glycerides and esters, and passing said mixture into transesterification stage (a).

    摘要翻译： 为了从脂肪酸甘油酯如植物油或动物油或脂肪或甘油酯的其它混合物生产脂肪酸乙酯，该方法包括以下步骤：（a）使用碱性催化剂将脂肪酸甘油酯与水合乙醇酯交换成 形成包含乙酯和过量乙醇的介质; （b）向所述介质中加入甘油相，并蒸发过量的乙醇以产生两个不混溶相，酯相和甘油相A，并将所述过量的乙醇再循环到步骤（a）; （c）分离所述甘油相A和所述酯相以获得所需的乙酯; （d）用酸中和所述甘油相A，分离所得的“脂肪酸+酯”相和甘油相B，并干燥后一相; （e）在碱性催化剂存在下，使至少一部分干燥的甘油相B对“脂肪酸+酯”相进行甘油分解，形成甘油酯和酯的混合物，并将所述混合物通入酯交换反应阶段 ）。

    Swimming pool cover with drainage and filter
    30.
    发明授权
    Swimming pool cover with drainage and filter 失效
    游泳池盖有排水和过滤器

    公开(公告)号：US5594960A

    公开(公告)日：1997-01-21

    申请号：US575736

    申请日：1995-12-18

    申请人： Robert Stern

    发明人： Robert Stern

    IPC分类号： E04H4/10

    CPC分类号： E04H4/10

    摘要： A cover for a water pool comprised of flexible waterproof material having a drainage opening positioned therein and a sleeve defining a passageway secured on the cover and in alignment with and intersecting the drainage opening allowing a filter to be slidably positionable therein for filtering of rain water and melting snow to remove particulate matter, the filter repositionable or removable for cleaning without the need for removing the cover for the water pool.

    摘要翻译： 一种用于水池的盖子，包括具有定位在其中的排水开口的柔性防水材料，以及限定固定在盖上并与排水口对准并与之相交的通道的套筒，允许过滤器可滑动地定位在其中以过滤雨水， 融雪除去颗粒物，过滤器可重新定位或可拆卸清洁，无需拆除水池盖。