公开(公告)号：US20180127469A1

公开(公告)日：2018-05-10

申请号：US15863673

申请日：2018-01-05

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Richard E. Lee ,  Ying Zhao ,  Elizabeth Griffith ,  Zhong Zheng ,  Aman P. Singh

IPC: C07K11/02 ,  C07K7/06 ,  A61K38/15 ,  C12N9/50 ,  A61K45/06 ,  A61K38/00

Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.