公开(公告)号：US09855217B2

公开(公告)日：2018-01-02

申请号：US15023110

申请日：2014-09-18

Applicant: STC.UNM ,  National Technology & Engineering Solutions of Sandia, LLC

Inventor： C. Jeffrey Brinker ,  Yu-Shen Lin

IPC: A61K9/14 ,  A61K9/127 ,  A61K31/7088 ,  B82Y5/00 ,  A61K9/51 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  C12N15/88 ,  B82Y15/00

CPC classification number: A61K9/1271 ,  A61K9/14 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/88

Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

公开(公告)号：US11045554B1

公开(公告)日：2021-06-29

申请号：US16443316

申请日：2019-06-17

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Oscar Negrete ,  C. Jeffrey Brinker ,  Torri Rinker ,  Annette Estelle LaBauve

IPC: A61K31/4965 ,  A61K47/69 ,  A61K47/54 ,  A61K31/517

Abstract: The present invention relates to lipid-coated particles for treating viral infections, including viral encephalitis infections. In particular, an antiviral compound can be disposed within the lipid-coated particle, thereby providing an antiviral carrier. Methods of making and using such carriers are described herein.

公开(公告)号：US09605344B2

公开(公告)日：2017-03-28

申请号：US14917566

申请日：2014-09-12

Applicant: STC.UNM

Inventor： Ying-Bing Jiang ,  Joseph L. Cecchi ,  Yaqin Fu ,  C. Jeffrey Brinker

IPC: C23C16/455 ,  C23C16/46

CPC classification number: C23C16/45525 ,  C23C16/45534 ,  C23C16/46

Abstract: An atomic layer deposition method is disclosed for preparing polypeptides. The method comprises providing a solid-phase support comprising a reactive amine monolayer in an atomic layer deposition (ALD) chamber. The solid-phase support is contacted with a first protected amino acid substituted with a protecting group by atomic layer deposition, wherein the protecting group is bonded to a non-side chain amino group of the protected amino acid. A carboxylic acid group of the first protected amino acid is reacted with the reactive amine monolayer, thereby coupling the first protected amino acid to the solid-phase support to produce a coupled-product.