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公开(公告)号：US20130059777A1
公开(公告)日：2013-03-07
申请号：US13562072
申请日：2012-07-30
申请人： Sanjay Bhanot , Kenneth W. Dobie
发明人： Sanjay Bhanot , Kenneth W. Dobie
IPC分类号： A61K31/7125 , A61K31/712 , A61P3/10 , A61P3/08 , A61K38/26 , A61P1/16 , A61P3/00 , A61P9/00 , A61K38/28 , C12N15/113 , A61P3/06
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for decreasing blood glucose levels in an animal, comprising administering to said animal an antisense inhibitor of glucose-6-phosphatase translocase expression alone or in combination with at least one glucose-lowering drug. Also provided are compositions and methods for treating diabetes and other metabolic disorders.
摘要翻译： 提供了用于降低动物体内血糖水平的组合物和方法，其包括向所述动物施用单独的葡萄糖-6-磷酸酶转位酶表达的反义抑制剂或与至少一种葡萄糖降低药物组合。 还提供了用于治疗糖尿病和其它代谢紊乱的组合物和方法。
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公开(公告)号：US20110213136A1
公开(公告)日：2011-09-01
申请号：US13102811
申请日：2011-05-06
IPC分类号： C07H21/04
CPC分类号： A61K45/06 , A61K38/00 , C12N9/0083 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y114/19001 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节硬脂酰辅酶A去饱和酶的表达。 组合物包含靶向编码硬脂酰辅酶A去饱和酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节硬脂酰辅酶A去饱和酶表达和治疗与硬脂酰辅酶A去饱和酶表达相关的疾病的方法。
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公开(公告)号：US07807652B2
公开(公告)日：2010-10-05
申请号：US12094598
申请日：2006-11-21
申请人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
发明人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP2的表达。 组合物包含靶向编码eIF4E-BP2的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP2表达和用于诊断和治疗与eIF4E-BP2表达相关的疾病和病症的方法。
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公开(公告)号：US20090082302A1
公开(公告)日：2009-03-26
申请号：US12274030
申请日：2008-11-19
申请人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
发明人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
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公开(公告)号：US20080280845A1
公开(公告)日：2008-11-13
申请号：US11915309
申请日：2006-05-24
申请人： Robert McKay , Ravi Jain , Kenneth W. Dobie , Sanjay K. Pandey , Sanjay Bhanot
发明人： Robert McKay , Ravi Jain , Kenneth W. Dobie , Sanjay K. Pandey , Sanjay Bhanot
IPC分类号： A61K31/7125 , C07H21/04 , A61P3/10 , A61P3/04 , A61P3/00
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.
摘要翻译： 本文公开了用于调节细胞，组织或动物中PTPRU表达的化合物，组合物和方法。 还提供了主动目标段验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防，改善和/或治疗糖尿病，肥胖症，胰岛素抵抗，胰岛素缺乏，高胆固醇血症，高血糖症，高脂血症，高甘油三酯血症，高脂肪肝，肝脂肪变性，脂肪性肝炎，非酒精性脂肪性肝炎，代谢综合征，心血管疾病和 通过给予针对PTPRU的反义化合物的冠心病。
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公开(公告)号：US07399853B2
公开(公告)日：2008-07-15
申请号：US10832777
申请日：2004-04-27
申请人： Susan M. Freier , Kenneth W. Dobie , Sanjay Bhanot , Robert McKay
发明人： Susan M. Freier , Kenneth W. Dobie , Sanjay Bhanot , Robert McKay
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。
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公开(公告)号：US20080153766A1
公开(公告)日：2008-06-26
申请号：US11613144
申请日：2006-12-19
IPC分类号： A61K31/7088 , C07H21/04 , A61P43/00 , A61P3/10
CPC分类号： A61K45/06 , A61K38/00 , C12N9/0083 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y114/19001 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节硬脂酰辅酶A去饱和酶的表达。 组合物包含靶向编码硬脂酰辅酶A去饱和酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节硬脂酰辅酶A去饱和酶表达和治疗与硬脂酰辅酶A去饱和酶表达相关的疾病的方法。
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公开(公告)号：US07229976B2
公开(公告)日：2007-06-12
申请号：US10671074
申请日：2003-09-25
申请人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter
发明人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.
摘要翻译： 提供反义化合物，组合物和方法用于调节叉头盒O1A的表达。 组合物包含靶向编码叉头盒O1A的核酸的反义化合物，特别是反义寡核苷酸。 提供使用这些化合物调制叉头盒O1A表达和用于治疗与叉头盒O1A的表达相关的疾病的方法，特别是用于治疗糖尿病的方法。
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公开(公告)号：US08642753B2
公开(公告)日：2014-02-04
申请号：US13566642
申请日：2012-08-03
申请人： Susan M. Freier , Kenneth W. Dobie , Robert McKay , Sanjay Bhanot
发明人： Susan M. Freier , Kenneth W. Dobie , Robert McKay , Sanjay Bhanot
IPC分类号： C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。
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公开(公告)号：US08202981B2
公开(公告)日：2012-06-19
申请号：US13009626
申请日：2011-01-19
申请人： Robert McKay , Ravi Jain , Kenneth W. Dobie , Sanjay K. Pandey , Sanjay Bhanot
发明人： Robert McKay , Ravi Jain , Kenneth W. Dobie , Sanjay K. Pandey , Sanjay Bhanot
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of PTPRU in a cell, tissue or animal. Also provided are methods of active target segment validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, obesity, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hyperfattyacidemia, liver steatosis, steatohepatitis, non-alcoholic steatohepatitis, metabolic syndrome, cardiovascular disease and coronary heart disease by administration of antisense compounds targeted to PTPRU.
摘要翻译： 本文公开了用于调节细胞，组织或动物中PTPRU表达的化合物，组合物和方法。 还提供了主动目标段验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了用于预防，改善和/或治疗糖尿病，肥胖症，胰岛素抵抗，胰岛素缺乏，高胆固醇血症，高血糖症，高脂血症，高甘油三酯血症，高脂肪肝，肝脂肪变性，脂肪性肝炎，非酒精性脂肪性肝炎，代谢综合征，心血管疾病和 通过给予针对PTPRU的反义化合物的冠心病。
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