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公开(公告)号：US08158759B2
公开(公告)日：2012-04-17
申请号：US13113996
申请日：2011-05-23
IPC分类号： C12P21/06
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译： 本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。 本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。
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公开(公告)号：US20110223160A1
公开(公告)日：2011-09-15
申请号：US13113996
申请日：2011-05-23
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译： 本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。 本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。
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公开(公告)号：US07807649B2
公开(公告)日：2010-10-05
申请号：US11739017
申请日：2007-04-23
申请人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter , Robert McKay , Sanjay K. Pandey
发明人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter , Robert McKay , Sanjay K. Pandey
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.
摘要翻译： 提供反义化合物，组合物和方法用于调节叉头盒O1A的表达。 组合物包含靶向编码叉头盒O1A的核酸的反义化合物，特别是反义寡核苷酸。 提供使用这些化合物调制叉头盒O1A表达和用于治疗与叉头盒O1A的表达相关的疾病的方法，特别是用于治疗糖尿病的方法。
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公开(公告)号：US20080153767A1
公开(公告)日：2008-06-26
申请号：US11739017
申请日：2007-04-23
申请人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter , Robert McKay , Sanjay K. Pandey
发明人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter , Robert McKay , Sanjay K. Pandey
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.
摘要翻译： 提供反义化合物，组合物和方法用于调节叉头盒O1A的表达。 组合物包含靶向编码叉头盒O1A的核酸的反义化合物，特别是反义寡核苷酸。 提供使用这些化合物调制叉头盒O1A表达和用于治疗与叉头盒O1A的表达相关的疾病的方法，特别是用于治疗糖尿病的方法。
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公开(公告)号：US06479250B1
公开(公告)日：2002-11-12
申请号：US09611452
申请日：2000-07-07
申请人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
发明人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
IPC分类号： C12Q148
CPC分类号： C07K14/705 , A61K38/1709 , A61K38/185 , A61K39/00 , C07K14/47 , C07K14/52 , G01N33/566 , G01N33/573 , G01N2500/00 , Y10S514/886 , Y10S514/893 , A61K2300/00
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
摘要翻译： 公开了与eck受体结合的配体。 更具体地，公开了与eck受体（eck受体结合蛋白或EBP）特异性结合的多肽和编码所述多肽的DNA序列。 使用eck受体配体和可溶性eck受体的治疗方法，以及包含其的药物组合物。 提供了用于检测粗样品中受体结合活性的快速且灵敏的方法。
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公开(公告)号：US6087167A
公开(公告)日：2000-07-11
申请号：US959524
申请日：1997-10-28
申请人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
发明人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K39/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/705 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , G01N33/573 , C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C07K14/705 , A61K38/1709 , A61K38/185 , C07K14/47 , C07K14/52 , G01N33/566 , G01N33/573 , A61K39/00 , G01N2500/00 , Y10S514/886 , Y10S514/893
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
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公开(公告)号：US07947809B2
公开(公告)日：2011-05-24
申请号：US11903481
申请日：2007-09-20
IPC分类号： C12P21/08
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译： 本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。 本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。
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公开(公告)号：US07229976B2
公开(公告)日：2007-06-12
申请号：US10671074
申请日：2003-09-25
申请人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter
发明人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.
摘要翻译： 提供反义化合物，组合物和方法用于调节叉头盒O1A的表达。 组合物包含靶向编码叉头盒O1A的核酸的反义化合物，特别是反义寡核苷酸。 提供使用这些化合物调制叉头盒O1A表达和用于治疗与叉头盒O1A的表达相关的疾病的方法，特别是用于治疗糖尿病的方法。
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公开(公告)号：US20130030036A1
公开(公告)日：2013-01-31
申请号：US13531087
申请日：2012-06-22
申请人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter , Robert McKay , Sanjay K. Pandey
发明人： Kenneth W. Dobie , Sanjay Bhanot , Murielle Veniant-Ellison , Richard A. Lindberg , John R. Shutter , Robert McKay , Sanjay K. Pandey
IPC分类号： C12N15/113 , A61P35/00 , A61K31/7088
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding forkhead box O1A. Methods of using these compounds for modulation of forkhead box O1A expression and for treatment of diseases associated with expression of forkhead box O1A are provided, in particular, for methods of treating diabetes.
摘要翻译： 提供反义化合物，组合物和方法用于调节叉头盒O1A的表达。 组合物包含靶向编码叉头盒O1A的核酸的反义化合物，特别是反义寡核苷酸。 提供使用这些化合物调制叉头盒O1A表达和用于治疗与叉头盒O1A的表达相关的疾病的方法，特别是用于治疗糖尿病的方法。
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公开(公告)号：US20090041784A1
公开(公告)日：2009-02-12
申请号：US11903481
申请日：2007-09-20
CPC分类号： C07K16/2869 , A61K2039/505 , C07K14/723 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies including methods of treating and preventing type 2 diabetes and related disorders by administering such antibodies to a subject in need of such treatment.
摘要翻译： 本公开提供了与抗原结合蛋白特别是特异性结合人胰高血糖素受体的抗体相关的组合物和方法。 本公开提供了编码这种抗原结合蛋白的核酸和抗体，以及制备和使用这些抗体的方法，包括通过向需要这种治疗的受试者施用此类抗体来治疗和预防2型糖尿病和相关疾病的方法。
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